Furadonin Avexima

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Furadonin Avexima: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. In case of impaired renal function
12. For violations of liver function
13. Drug interactions
14. Analogs
15. Terms and conditions of storage
16. Terms of dispensing from pharmacies
17. Reviews
18. Price in pharmacies

Latin name: Furadonin Avexima

ATX code: J01XE01

Active ingredient: nitrofurantoin (nitrofurantoin)

Producer: Irbit Chemical and Pharmaceutical Plant, JSC (Russia)

Description and photo updated: 22.11.2018

Prices in pharmacies: from 47 rubles.

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Furadonin Avexima is an antimicrobial agent used in the treatment of urinary tract infections.

Release form and composition

Dosage form of release of Furadonin Avexim - tablets: flat-cylindrical, yellow or yellow with a greenish tinge (in a cardboard box 1-5 contour / non-cell packs of 10 tablets; 1 blister or 1 can of 20 tablets).

Composition of 1 tablet:

active substance: furadonin (nitrofurantoin) - 50 or 100 mg;
auxiliary components (50/100 mg): aerosil - 2/4 mg; potato starch - 46.15 / 92.3 mg; stearic acid - 1/2 mg; polysorbate 80 - 0.85 / 1.7 mg.

Pharmacological properties

Pharmacodynamics

Furadonin Avexima belongs to the group of antimicrobial agents from the nitrofuran group; it is mainly used to treat urinary tract infections. Nitrofurantoin promotes disruption of protein synthesis in bacteria and the permeability of the cell membrane.

In small doses, the substance has a bacteriostatic effect, in large doses it is bactericidal.

Effective against gram-positive / gram-negative bacteria, including Proteus spp., Escherichia coli, Streptococcus spp., Staphylococcus spp., Shigella flexneri, Shigella dysenteriae, Shigella sonnei, Shigella boydii.

Resistant to nitrofurantoin Acinetobacter spp., Pseudomonas cepacia, Pseudomonas aeruginosa, Providencia spp.

The drug is not used in the treatment of urinary tract infections caused by mycoplasmas, chlamydia, gonococci.

Pharmacokinetics

Nitrofurantoin is well absorbed in the gastrointestinal tract. Bioavailability is 50%, food intake increases bioavailability. The absorption rate depends on the size of the crystals - the microcrystalline form is characterized by rapid solubility and absorption rate, a short time to reach C _max (maximum concentration of the substance) in urine.

The connection with blood plasma proteins is 60%. Penetrates through the blood-brain barrier, placenta, excreted in breast milk. Effective therapeutic concentration is achieved in the urinary tract rather than in tissues and blood.

Metabolism takes place in muscle tissue and liver.

T _1/2 (half-life) is in the range of 20-25 minutes. Completely excreted by the kidneys (unchanged - from 30 to 50%).

With impaired renal function, T _1/2 and the plasma concentration of nitrofurantoin in the blood increase. When creatinine clearance is less than 60 ml / min, the therapeutic concentration of the substance in the urine is not achieved, accumulation of nitrofurantoin and an increased likelihood of toxicity are possible.

Nitrofurantoin is highly active in acidic urine. At urine pH above 8, Furadonin Avexima loses its bactericidal activity.

Indications for use

According to the instructions, Furadonin Avexim is prescribed for bacterial infections of the urinary tract caused by microorganisms sensitive to the action of nitrofurantoin:

severe complicated recurrent infections;
acute uncomplicated infections;
urinary tract infections, including in uncomplicated chronic diseases and during urological operations / examinations - cystoscopy, catheterization of the urinary tract, etc. (for prophylactic purposes).

Contraindications

Absolute:

chronic renal failure;
heart failure II – III stage;
deficiency of glucose-6-phosphate dehydrogenase;
chronic hepatitis;
cirrhosis of the liver;
acute porphyria;
oliguria, anuria;
polyneuropathy / neuritis;
pulmonary fibrosis;
pregnancy and lactation;
age up to 3 or 12 years (for tablets 50 or 100 mg, respectively);
individual intolerance to the components of the drug.

Relative (Furadonin Avexima is prescribed under medical supervision):

diabetes;
electrolyte imbalance;
anemia;
failure of hepatic function;
deficiency of B vitamins;
a tendency to the appearance of peripheral neuropathies (itching of the legs, arms, numbness);
lung disease.

Instructions for the use of Furadonin Avexim: method and dosage

Furadonin Avexim is taken orally with plenty of water.

Recommended application scheme:

adults: 100-150 mg 3-4 times a day; the maximum single dose is 300 mg, the daily dose is 600 mg;
children: 5-8 mg / kg daily in 4 divided doses. Children 3–12 years of age are prescribed Furadonin Avexim 50 mg tablets.

The duration of treatment for acute urinary tract infections is from 7 to 10 days.

It should be borne in mind that the symptoms of the disease may disappear before the infection is cured, and if the therapy with Furadonin Avexima is discontinued, the disease may worsen again.

If nausea occurs, you need to reduce the dose or stop taking the drug.

Preventive, anti-relapse therapy with Furadonin Avexima is carried out from 3 to 12 months (depending on the nature of the disease). In such cases, the daily dose is 1–2 mg / kg.

Side effects

Possible adverse reactions (> 10% - very often;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01% - very rare; with an uncertain frequency - in cases where it is impossible to establish the frequency of occurrence of violations):

immune system: very rarely - lupus-like syndrome (in the form of a rash, eosinophilia, fever, arthralgia, while an increase in two or more parameters is observed in the blood serum - antinuclear antibodies, antibodies to the basement membrane of the glomeruli or smooth muscles and the Coombs reaction); in some cases - anaphylaxis, angioedema, autoimmune reactions that are associated with chronic changes in the liver / lungs;
respiratory system: very rarely - acute / chronic reactions of hypersensitivity of the lungs (in the form of fever, eosinophilia, cough, chest pain, shortness of breath), pleurisy, broncho-obstructive syndrome, interstitial changes in the lungs; the appearance of pulmonary infiltration or seals and pleural effusion is possible for several hours or days after the start of taking Furadonin Avexim, after discontinuation of therapy, they usually resolve; with prolonged therapy, acute / subacute pulmonary symptoms may imperceptibly develop, including pulmonary fibrosis; fibrosis can be irreversible, especially if the drug is not canceled after the onset of symptoms;
nervous system: often - headache; rarely - increased intracranial pressure; with an indefinite frequency - drowsiness, dizziness, nystagmus, asthenia, peripheral polyneuropathy (including optic neuritis, the first symptoms appear as a burning sensation / numbness in the legs, muscle weakness);
digestive system: often - vomiting, nausea, lack of appetite; rarely - pancreatitis, inflammation of the salivary glands, diarrhea, abdominal pain;
infectious / parasitic diseases: with an uncertain frequency - superinfection of the genitourinary tract (most often caused by Pseudomonas aeruginosa or Candida spp.), pseudomembranous colitis;
genitals / mammary gland: very rarely - transient spermatogenesis disorder;
blood / lymphatic system: rarely - thrombocytopenia, leukopenia, megaloblastic anemia, agranulocytosis or granulocytopenia, hemolytic anemia against the background of glucose-6-phosphate dehydrogenase deficiency;
skin / subcutaneous tissue: often - allergic reactions (in the form of skin rashes, hives, itching); very rarely - erythema polyform, exfoliative dermatitis;
liver / biliary tract: rarely - cholestatic jaundice, hepatitis (violations are dose-independent and disappear after drug withdrawal);
others: rarely - hair loss (reversible), joint pain.

Overdose

Main symptoms: vomiting, nausea, dizziness, headache.

Therapy: a large amount of fluid is shown, which leads to an increase in the excretion of Furadonin Avexim in the urine. Dialysis is effective.

special instructions

When taking Furadonin Avexim with food and liquid in large quantities, the frequency of adverse reactions from the digestive system decreases.

If the first signs of peripheral neuropathy appear (development of paresthesias), Furadonin Avexim is canceled, since this complication can be life-threatening. Also, the withdrawal of the drug is required with the development of hepatitis, blood disorders, the appearance of the first reactions of hypersensitivity of the lungs.

Furadonin Avexima should not be used for the treatment of prostatitis, purulent paranephritis and diseases of the renal cortex. Also, the drug is not prescribed for the treatment of pyelonephritis, which is accompanied by perirenal inflammation or inflammation of the parenchymal tissue.

Nitrofurantoin can stain urine brown or dark yellow.

With prolonged therapy, it is necessary to monitor the function of the lungs (especially in elderly patients who may have deterioration in lung function) and liver.

The therapeutic concentration of nitrofurantoin in urine with creatinine clearance less than 60 ml / min is not achieved. This increases the risk of toxicity and accumulation of the active substance.

If signs of hemolysis appear in patients with suspected deficiency of glucose-6-phosphate dehydrogenase, therapy with Furadonin Avexim is canceled.

You cannot drink alcoholic beverages during treatment.

Combined use with drugs that cause impaired renal function is not recommended.

During therapy, when determining glucose in urine, false positive reactions may be observed.

Taking Furadonin Avexim can lead to the appearance of resistant microorganisms.

Influence on the ability to drive vehicles and complex mechanisms

During the period of therapy with Furadonin Avexim, patients should be careful when driving motor vehicles, which is associated with the likelihood of adverse reactions from the nervous system.

Application during pregnancy and lactation

Furadonin Avexima is not prescribed during pregnancy / lactation.

Pediatric use

Furadonin Avexim 50 mg tablets are contraindicated in children under 3 years old, 100 mg tablets - up to 12 years old.

With impaired renal function

Therapy with Furadonin Avexim is contraindicated in patients with chronic renal failure.

For violations of liver function

cirrhosis of the liver and chronic hepatitis: therapy is contraindicated;
failure of hepatic function: Furadonin Avexima should be used under medical supervision.

Drug interactions

Possible interactions:

sulfinpyrazone, probenecid (agents that promote the excretion of uric acid and block tubular secretion): the concentration of nitrofurantoin in the urine decreases, and in the blood it increases (leading to a decrease in the antibacterial effect and an increase in toxicity);
adsorbents and antacids: absorption of nitrofurantoin decreases;
drugs that increase the pH of urine: the antibacterial effect of nitrofurantoin in an alkaline environment decreases, the combination is not recommended;
quinolone group preparations (fluoroquinolones, nalidixic acid): their antibacterial effect decreases; Furadonin Avexima is incompatible with fluoroquinolones.

Analogs

Furadonin Avexim analogs are Furadonin, Furadonin-LekT.

Terms and conditions of storage

Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.

Shelf life is 4 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Furadonin Avexim

According to reviews, Furadonin Avexima is effective in the treatment of inflammatory processes of the genitourinary system. Of the advantages, they note the low cost and the rapid development of the therapeutic action. Among the shortcomings, they most often indicate the appearance of nausea, in some cases - severe.

Price for Furadonin Avexima in pharmacies

The approximate price for Furadonin Avexim (20 tablets of 50 mg each) is 89 rubles.