Stopdiar - Instruction, Application For Children, Price, Reviews, Suspension

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Stopdiar

Stopdiar: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Stopdiar

ATX code: A07AX03

Active ingredient: nifuroxazide (nifuroxazide)

Manufacturer: Gedeon Richter (Hungary, Romania, Poland)

Description and photo update: 2018-22-10

Prices in pharmacies: from 177 rubles.

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Stopdiar is an antidiarrheal drug with antibacterial action.

Release form and composition

Stopdiar is released in the following forms:

• film-coated tablets: biconvex, round, yellow (24 pcs. in a blister, 1 blister in a cardboard box);
• capsules: size No. 1, gelatinous hard, body and cap are yellow; contents of capsules - yellow powder (12 pcs. in a blister, 1 blister in a cardboard box);
• oral suspension: pale yellow, with a banana smell; during storage, the formation of a precipitate is allowed, which disappears after shaking with the return of the suspension to a homogeneous state (90 ml in a glass orange bottle with a volume of 125 ml, in a cardboard box 1 bottle with a double dosing spoon with a capacity of 2.5 and 5 ml).

Composition of 1 tablet:

• active substance: nifuroxazide - 100 mg;
• additional components: potato starch, aerosil hydrophilic 200, (colloidal silicon dioxide), talc, magnesium stearate, gelatin;
• film shell: polyethylene glycol 20,000, hypromellose, quinoline yellow dye, talc, titanium dioxide.

Composition of 1 capsule:

• active substance: nifuroxazide - 200 mg;
• additional components: corn starch, pregelatinized corn starch, magnesium stearate, sucrose;
• cap and capsule body: titanium dioxide, gelatin, iron oxide yellow dye.

Composition of 5 ml suspension:

• active substance: nifuroxazide - 220 mg;
• additional substances: sodium hydroxide, carbomer, methyl parahydroxybenzoate, citric acid monohydrate, sucrose, antifoam emulsion (30% simethicone emulsion), water, banana flavor.

Pharmacological properties

Pharmacodynamics

Nifuroxazide is an antimicrobial agent derived from nitrofuran. The substance exhibits high antibacterial activity against Clostridium perfringens, Shigella spp., Salmonella spp., Escherichia coli, Vibrio cholerae, Campylobacter jejuni, pathogenic Staphylococcus spp., Vibrio parahaemolyticus and Vibrions. Weak sensitivity to nifuroxazide is noted in Citrobacter spp., Proteus indologenes, and Enterobacter cloacae. Resistant to the drug are Klebsiella spp., Pseudomonas spp., Providencia spp., Proteus mirabilis.

The active ingredient Stopdiar does not disturb the balance of the normal bacterial flora of the intestine. The detailed mechanism of action of the substance is unknown, it is assumed that it inhibits the activity of dehydrogenases and prevents the synthesis of proteins in pathogenic bacteria. The drug in medium therapeutic doses has bacteriostatic properties, and in higher doses - bactericidal. The effectiveness of the remedy is noted from the first hours of therapy.

Nifuroxazide does not cause the emergence of resistant strains of pathogens, and when it is used, there is no development of cross-resistance to other antibacterial agents. This makes it possible, if necessary, to use the drug for generalized infections in complex treatment with systemic drugs. Against the background of intestinal infections of a viral nature, nifuroxazide prevents the appearance of bacterial superinfection.

The effect of the drug is not influenced by the pH in the intestinal lumen, nor by the sensitivity of microorganisms to antibacterial agents. The drug acts exclusively in the intestinal lumen.

Pharmacokinetics

Since nifuroxazide is difficult to dissolve, after oral administration, it is practically not absorbed from the gastrointestinal tract (GIT), while forming a high concentration in the intestine. Due to these pharmacokinetic features, the substance demonstrates an exclusively enteral antimicrobial effect, does not exhibit systemic antibacterial activity and does not have a general toxic effect. Stopdiar is excreted through the intestines. Does not affect the biochemical and clinical parameters of the blood test.

Indications for use

Pills

The tablets are recommended for acute and chronic diarrhea caused by bacteria sensitive to nifuroxazide.

Capsules

Capsules are indicated for acute bacterial diarrhea, proceeding without an increase in body temperature, deterioration in general condition, and intoxication.

Suspension

The suspension is used for acute and chronic diarrhea excited by intestinal gram-positive bacteria (Streptococcus spp., Staphylococcus spp.), As well as some gram-negative bacteria (Enterobacter spp., Proteus spp., Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp., Haemophilus influenzae).

Contraindications

• prematurity (for suspension);
• age up to 2 months - for suspension, up to 3 years - for capsules, up to 7 years - for tablets;
• hypersensitivity to any of the constituents of the drug and nitrofuran derivatives.

For Stopdiar capsules, additional contraindications are pregnancy and sucrase and isomaltase deficiency, glucose-galactose malabsorption syndrome, fructose intolerance (due to sucrose included in the composition).

Instructions for use of Stopdiar: method and dosage

Stopdiar is taken orally.

Pills

The tablets are swallowed whole, without crushing or chewing, drinking plenty of water.

Stopdiar for children after 7 years of age and adults is prescribed 4 times a day every 6 hours, 200 mg (2 tablets). The course of treatment is 3 days. If after this period you cannot achieve the desired effect, you need to contact a specialist.

Capsules

Children aged 3 to 6 years take 200 mg 3 times a day (1 capsule), the daily dose should not exceed 600 mg.

Children over 6 years of age and adults take Stopdiar 4 times a day, 200 mg, the daily dose is 800 mg. If there is no improvement in the condition during the first 3 days of therapy, it is required to consult a specialist.

Suspension

Suspension Stopdiar should be taken at regular intervals, regardless of the meal. The duration of therapy is 5-7 days.

Recommended dosage regimen, taking into account the patient's age:

• from 2 to 6 months: 2 times a day, 1-2 scoops per 2.5 ml;
• from 6 months to 6 years: 3 times a day, 1 measuring spoon per 5 ml;
• 6 years and older: 4 times a day, 1 measuring spoon per 5 ml.

One 2.5 ml scoop contains 110 mg of nifuroxazide, 5 ml contains 220 mg.

Before using the drug, the bottle should be shaken thoroughly until a homogeneous suspension is obtained.

Side effects

Stopdiar is usually well tolerated; adverse reactions are observed in extremely rare cases. If there is an increase in the manifestations of any of the following symptoms or the occurrence of new disorders, it is required to consult a doctor.

Pills

With existing hypersensitivity to Stopdiar, in isolated cases, the following side effects may occur:

• hematopoietic system: granulocytopenia;
• digestive system: nausea, abdominal pain, worsening diarrhea;
• allergic reactions: skin rash, itching, swelling of the tongue, lips, face, shortness of breath;
• skin and subcutaneous fat: nodular pruritus, skin rash (including pustular).

Capsules

It is possible to develop allergic reactions in the form of urticaria, skin rashes, anaphylactic shock, Quincke's edema.

Suspension

• digestive system: increased diarrhea, nausea, short-term abdominal pain;
• others: isolated cases - itching, skin rashes, shortness of breath.

The appearance of these violations does not require the cancellation of the Stopdiar suspension.

Overdose

Overdose cases of Stopdiar have not been registered so far. If this condition is suspected, gastric lavage and symptomatic treatment should be performed.

special instructions

During the period of therapy, it is required to refrain from drinking ethanol-containing drinks, since ethanol can lead to the development of a disulfiram-like reaction, the symptoms of which are a sensation of heat on the face and upper body, skin flushing, abdominal pain, vomiting, pronounced aggravation of diarrhea, tachycardia, difficulty breathing, noise in the head, feeling of fear.

In case of bacterial diarrhea, accompanied by signs of systemic damage, such as fever, deterioration of the general condition, symptoms of infection or intoxication, it is necessary to consult a doctor to decide on the appointment of antibacterial agents of systemic action.

Stopdiar should not be used for more than 7 days, as it is not indicated for long-term therapy.

Due to the fact that the drug is not absorbed from the gastrointestinal tract, in the case of severe invasive diarrhea, the use of systemic antibiotics is necessary.

When symptoms of dehydration appear, it is necessary to replenish the loss of fluid from the body (parenteral or oral), for adults - approximately 2 liters of fluid per day.

If the occurrence of hypersensitivity reactions is observed, stopdiar should be stopped immediately.

During the use of the product, it is recommended to follow a diet that excludes juices, raw vegetables and fruits, fatty and spicy dishes, spices.

Before prescribing the suspension to infants, it is necessary to make sure that they do not have a congenital deficiency of enzymes that break down sucrose.

Influence on the ability to drive vehicles and complex mechanisms

According to the instructions, Stopdiar does not adversely affect the ability to control complex, potentially dangerous mechanisms, including driving vehicles.

Application during pregnancy and lactation

It is contraindicated for pregnant women to take Stopdiar capsules. If it is necessary to take capsules during lactation, breastfeeding is possible only with a short course of therapy.

Stopdiar tablets and suspension during pregnancy and breastfeeding should be used only if the expected benefit to the mother significantly outweighs the possible risk to the health of the fetus / child.

Pediatric use

Taking Stopdiar tablets is contraindicated in children under 7 years old, capsules - under 3 years old, suspensions - under 2 months, as well as premature babies.

Drug interactions

Due to the fact that the drug is not absorbed from the gastrointestinal tract and cannot enter the circulatory system, its interaction with drugs that have a systemic effect is unlikely and is still unknown.

During the period of therapy with Stopdiar, it is recommended to avoid its combined use with other oral drugs because of the pronounced adsorption properties of nifuroxazide.

Capsules are not recommended for use in combination with drugs that depress the function of the central nervous system.

Analogs

Analogues of Stopdiar are: Nifuroxazide, Adisord, Elufor, Ersefuril, Ekofuril, Mirofuril, Enterofuril.

Terms and conditions of storage

Store in a place protected from light and moisture (for tablets), out of reach of children. Storage temperature of tablets - 15-25 ° C, capsules and suspensions - up to 25 ° C.

Shelf life:

• tablets - 4 years;
• suspension - 3 years;
• capsules - 2 years.

The suspension after opening the bottle can be stored for no more than 14 days.

Terms of dispensing from pharmacies

Capsules and tablets are available without a prescription, suspension - with a prescription.

Reviews of Stopdiar

Almost all reviews about Stopdiar are positive. Patients who have taken the drug speak of it as an effective treatment for diarrhea and intestinal infections in children and adults. The suspension is noted to have a pleasant taste and smell, which is important when prescribing Stopdiar for children.

To the disadvantages of the drug, patients include the appearance of allergic reactions, and also in Stopdiar in the form of a suspension - a short shelf life after opening. In some reviews, dissatisfaction is expressed with the large amount of flavor in the suspension.

Price for Stopdiar in pharmacies

The price of Stopdiar depends on the form of release and can be approximately:

• film-coated tablets (100 mg / pc.), 24 pcs. in the package - from 180 to 240 rubles;
• capsules (200 mg / pc.), 12 pcs. in the package - from 220 to 240 rubles;
• suspension for oral administration (220 mg / 5 ml), 90 ml in a package - from 240 to 340 rubles.

Stopdiar: prices in online pharmacies

Drug name Price Pharmacy

Stopdiar 100 mg film-coated tablets 24 pcs. 177 r Buy

Stopdiar tablets p.p. 100mg 24 pcs. 224 r Buy

Stopdiar 220 mg / 5 ml oral suspension 90 ml 1 pc. 227 r Buy

Stopdiar 200 mg capsules 12 pcs. 237 r Buy

Stopdiar capsules 200mg 12 pcs. RUB 298 Buy

Stopdiar suspension for internal approx. 220mg / 5ml 90ml 379 r Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!