Augmentin - Instructions, Use Of A Suspension For Children, Price, Reviews

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Augmentin

Augmentin: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Use in the elderly
14. 14. Drug interactions
15. 15. Analogs
16. 16. Terms and conditions of storage
17. 17. Terms of dispensing from pharmacies
18. 18. Reviews
19. 19. Price in pharmacies

Latin name: Augmentin

ATX code: J01CR02

Active ingredient: amoxicillin + clavulanic acid (Amoxicillin + Clavulanic acid)

Manufacturer: GlaxoSmithKline PLC (UK)

Description and photo update: 2019-19-08

Prices in pharmacies: from 58 rubles.

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Augmentin is a broad-spectrum antibiotic that affects both gram-negative and gram-positive bacteria.

Release form and composition

The antibiotic is available in the following forms:

• film-coated tablets: oval, white or almost white, at the break - from white-yellowish to almost white [250 mg (250 + 125) each: with a depressed inscription on one side of the AUGMENTIN tablet (in blisters of 10 pcs., in a cardboard box 2 blisters); 500 mg each (500 + 125): with an embossed inscription "AC" and a line on one side (in blisters of 7 or 10 pcs., in a cardboard box 2 blisters); 875 mg each (875 + 125): with the letters "A" and "C" on both sides of the tablet and a risk of breaking on one side (in blisters of 7 pcs., in a cardboard box 2 blisters)];
• powder for preparation of suspension for oral administration: white or almost white, with a characteristic odor; upon dilution, a suspension is obtained (white or almost white), in which a precipitate forms at rest (in glass bottles, 1 bottle with a measuring cap in a cardboard box);
• powder for the preparation of a solution for intravenous administration: from white to almost white (10 vials in a cardboard box).

As active substances in Augmentin, a combination of clavulanic acid (in the form of potassium salt) and amoxicillin (in the form of sodium salt) is used.

1 tablet contains:

• active substances: clavulanic acid - 125 mg, amoxicillin (in the form of trihydrate) - 250, 500 or 875 mg;
• excipients: sodium carboxymethyl starch, colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose.

The composition of the film coating of the tablets includes: hypromellose, hypromellose (5cP), macrogol 6000, macrogol 4000, dimethicone, titanium dioxide.

5 ml of ready-made suspension for oral administration contains:

• active substances [ratio of amoxicillin (in the form of trihydrate) to clavulanic acid (in the form of potassium salt)]: 125 mg / 31.25 mg, 200 mg / 28.5 mg, 400 mg / 57 mg;
• excipients: hypromellose, xanthan gum, succinic acid, aspartame, colloidal silicon dioxide, flavors (orange 1, orange 2, raspberry, "Molasses"), silicon dioxide.

1 bottle (1200 mg) of solution for intravenous administration contains active substances:

• amoxicillin (in the form of sodium salt) - 1000 mg;
• clavulanic acid (in the form of potassium salt) - 200 mg.

Pharmacological properties

Augmentin is characterized by antibacterial and bactericidal action and belongs to penicillins from the β-lactam group.

Pharmacodynamics

Amoxicillin is a semisynthetic broad-spectrum antibiotic that is active against many gram-negative and gram-positive microorganisms. However, amoxicillin is susceptible to degradation by β-lactamases, so the spectrum of its activity does not apply to bacteria producing this enzyme.

Clavulanic acid has a structure similar to penicillins and is a β-lactamase inhibitor, which explains its ability to inactivate a wide range of β-lactamases, which are present in microorganisms showing resistance to cephalosporins and penicillins. This active component effectively acts on plasmid β-lactamases, most often providing bacterial resistance, and is ineffective against chromosomal type 1 β-lactamases, which are not subject to inhibition by clavulanic acid.

The inclusion of clavulanic acid in Augmentin helps protect amoxicillin from destruction by enzymes - β-lactamases, which provides an expansion of the antibacterial spectrum of this substance.

In vitro, the following microorganisms are sensitive to the combination of amoxicillin with clavulanic acid:

• gram-negative aerobes: Vibrio cholerae, Bordetella pertussis, Pasteurella multocida, Haemophilus influenzae, Neisseria gonorrhoeae, Moraxella catarrhalis, Helicobacter pylori;
• gram-positive aerobes: coagulase-negative staphylococci (methicillin-sensitive strains), Staphylococcus saprophyticus (methicillin-sensitive), Staphylococcus aureus (methicillin-sensitive), Bacillus anthraccus agracis, Streptocotia (other β-hemolytic streptococci), Streptococcus pyogenes, Enterococcus faecalis, Nocardia asteroides, Listeria monocytogenes;
• gram-negative anaerobes: Prevotella spp., Bacteroides fragilis, Bacteroides spp., Porphyromonas spp., Fusobacterium spp., Fusobacterium nucleatum, Eikenella corrodens, Capnocytophaga spp.;
• gram-positive anaerobes: Peptostreptococcus spp., Peptostreptococcus magnus, Peptostreptococcus micros, Peptostreptococcus niger, Clostridium spp.;
• others: Treponema pallidum, Leptospira icterohaemorrhagiae, Borrelia burgdorferi.

The following microorganisms are characterized by acquired resistance to the combination of amoxicillin with clavulanic acid:

• gram-positive aerobes: streptococci of the Viridans group, Corynebacterium spp., Streptococcus pneumoniae (strains of this type of bacteria do not produce β-lactamases, and the therapeutic efficacy of the drug has been confirmed by the results of clinical studies), Enterococcus faecium;
• gram-negative aerobes: Shigella spp., Escherichia coli, Salmonella spp., Klebsiella spp., Klebsiella pneumoniae, Klebsiella oxytoca, Proteus spp., Proteus vulgaris, Proteus mirabilis.

The following bacteria have natural resistance to the drug, which contains amoxicillin and clavulanic acid:

• gram-negative aerobes: Yersinia enterocolitica, Acinetobacter spp., Stenotrophomonas maltophilia, Citrobacter freundii, Serratia spp., Enterobacter spp., Pseudomonas spp., Hafnia alvei, Providencia spp., Morganella pneumophila, Legionella pneumophilia;
• others: Coxiella burnetii, Chlamydia psittaci, Chlamydia pneumoniae, Chlamydia spp., Mycoplasma spp.

The sensitivity of the pathogen to monotherapy with amoxicillin suggests a similar sensitivity to the combination of amoxicillin with clavulanic acid.

Pharmacokinetics

Clavulanic acid and amoxicillin are rapidly and almost 100% absorbed from the gastrointestinal tract (GIT) when taken orally. The absorption of the active components of Augmentin is considered optimal when the drug enters the body at the beginning of a meal.

The use of a suspension for oral administration has been studied in clinical trials in which healthy volunteers aged 2 to 12 years participated. They took Augmentin at a dosage of 125 mg / 31.25 mg 5 ml on an empty stomach in 3 divided doses, with the daily dose of amoxicillin and clavulanic acid being 40 and 10 mg / kg, respectively. As a result of the experiment, the following values of pharmacokinetic parameters were obtained:

• clavulanic acid: maximum concentration 2.7 ± 1.6 mg / ml, time to reach maximum plasma content 1.6 hours (range of variation 1-2 hours), AUC 5.5 ± 3.1 mg × h / ml, half-life of 0.94 ± 0.05 hours;
• amoxicillin: maximum concentration 7.3 ± 1.7 mg / ml, time to reach maximum plasma content 2.1 hours (range of variation 1.2-3 hours), AUC 18.6 ± 2.6 mg × h / ml, half-life of 1.0 ± 0.33 hours.

Also, comparative studies of the features of the pharmacokinetics of Augmentin were carried out when taken in the form of tablets, film-coated (on an empty stomach). The results of determining the pharmacokinetic parameters depending on the intake of Augmentin, clavulanic acid and amoxicillin in various doses were as follows:

• one tablet of Augmentin with a dosage of 250 mg / 125 mg: for amoxicillin - the maximum concentration is 3.7 mg / l; time to reach the maximum concentration in blood plasma 1.1 hours; AUC (area under the concentration-time curve) 10.9 mg × h / ml; half-life (T _1/2) 1 hour. For clavulanic acid, the maximum concentration is 2.2 mg / l; the time to reach the maximum concentration in blood plasma - 1.2 hours; AUC 6.2 mg x h / ml; T _1/2 - 1.2 hours;
• two tablets of Augmentin with a dosage of 250 mg / 125 mg: for amoxicillin - the maximum concentration is 5.8 mg / l; time to reach the maximum concentration in blood plasma 1.5 hours; AUC 20.9 mg × h / ml; T _1/2 - 1.3 hours. For clavulanic acid, the maximum concentration is 4.1 mg / l; the time to reach the maximum concentration in blood plasma is 1.3 hours; AUC 11.8 mg × h / ml; T _1/2 - 1 hour;
• one tablet of Augmentin with a dosage of 500 mg / 125 mg: for amoxicillin - the maximum concentration is 6.5 mg / l; time to reach the maximum concentration in blood plasma 1.5 hours; AUC 23.2 mg × h / ml; T _1/2 - 1.3 hours. For clavulanic acid, the maximum concentration is 2.8 mg / l; the time to reach the maximum concentration in blood plasma is 1.3 hours; AUC 7.3 mg x h / ml; T _1/2 - 0.8 hours;
• amoxicillin alone at a dose of 500 mg: maximum concentration 6.5 mg / l; the time to reach the maximum concentration in blood plasma is 1.3 hours; AUC 19.5 mg × h / ml; T _1/2 - 1.1 hours;
• clavulanic acid alone at a dose of 125 mg: maximum concentration 3.4 mg / l; the time to reach the maximum concentration in blood plasma is 0.9 hours; AUC 7.8 mg × h / ml; T _1/2 - 0.7 hours.

The pharmacokinetics of the drug was also studied with intravenous bolus administration of Augmentin to healthy volunteers. As a result, the following values of pharmacokinetic parameters were obtained depending on the dose:

• dosage 1000 mg / 200 mg: for amoxicillin - the maximum concentration is 105.4 μg / ml; T _1/2 - 0.9 hours; AUC 76.3 mg × h / ml, excreted in the urine during the first 6 hours after administration of 77.4% of the active substance. For clavulanic acid, the maximum concentration is 28.5 μg / ml; T _{1/2 -} 0.9 hours; AUC 27.9 mg × h / ml, excreted in the urine during the first 6 hours after administration of 63.8% of the active substance;
• dosage of 500 mg / 100 mg: for amoxicillin - the maximum concentration is 32.2 μg / ml; T _1/2 - 1.07 hours; AUC 25.5 mg × h / ml, excreted in the urine during the first 6 hours after administration of 66.5% of the active substance. For clavulanic acid, the maximum concentration is 10.5 μg / ml; T _1/2 - 1.12 hours; AUC 9.2 mg × h / ml, excreted in the urine during the first 6 hours after administration of 46% of the active substance.

Both with oral administration and with intravenous administration of the drug, clavulanic acid and amoxicillin in therapeutic concentrations are determined in the interstitial fluid and various tissues (in the tissues of the abdominal cavity, adipose and muscle tissues, skin, gallbladder, purulent discharge, bile, peritoneal and synovial liquids).

Both active components of Augmentin weakly bind to blood plasma proteins. The research results indicate that the degree of binding of amoxicillin to blood plasma proteins is approximately 18%, and clavulanic acid - 25%. Experiments on animals do not confirm the accumulation of active substances in any organs.

Amoxicillin penetrates into breast milk, which also determines clavulanic acid in trace concentrations. The negative effects of these substances on the health of breastfed children, except for the development of candidiasis of the oral mucous membranes, diarrhea and the risk of sensitization, have not been identified.

The study of reproductive function in animals when using amoxicillin in combination with clavulanic acid showed that the active components of Augmentin penetrate the placental barrier, but do not have a negative effect on the fetus.

From 10 to 25% of the taken dose of amoxicillin is excreted in the urine in the form of penicillic acid, a metabolite that does not exhibit pharmacological activity. Clavulanic acid is extensively metabolized to form 1-amino-4 hydroxy-butan-2-one and 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid, and is excreted through the gastrointestinal tract, with urine, as well as with exhaled air in the form of carbon dioxide.

Amoxicillin is excreted mainly through the kidneys, while clavulanic acid is characterized by both renal and extrarenal mechanisms. Approximately 45-65% of clavulanic acid and about 60-70% of amoxicillin are excreted unchanged in the urine during the first 6 hours after taking 1 tablet of 500 mg / 125 mg or 250 mg / 125 mg or after a single bolus injection of Augmentin at a dosage of 500 mg / 100 mg or 1000 mg / 200 mg. Simultaneous administration of probenecid inhibits the elimination of amoxicillin, but does not affect the elimination of clavulanic acid.

Indications for use

According to the instructions, Augmentin is prescribed for infections of a bacterial nature caused by microorganisms exhibiting antibiotic sensitivity:

• infections of the skin, soft tissues;
• respiratory tract infections: bronchitis, lobar bronchopneumonia, empyema, lung abscess;
• infections of the genitourinary system: cystitis, urethritis, pyelonephritis, abortion sepsis, syphilis, gonorrhea, infections of organs in the pelvic region;
• infections of bones and joints: osteomyelitis;
• odontogenic infections: periodontitis, odontogenic maxillary sinusitis, severe dental abscesses;
• infections that have arisen as a complication after surgery: peritonitis.

Contraindications

• a history of hypersensitivity to clavulanic acid, amoxicillin, other components of the drug and beta-lactam antibiotics (cephalosporins, penicillins);
• previous cases of jaundice or liver dysfunction when using a combination of clavulanic acid with amoxicillin in history;
• impaired renal function (powder for suspension for oral administration 200 mg / 28.5 mg and 400 mg / 57 mg; tablets 875 mg / 125 mg);
• phenylketonuria (powder for oral suspension).

Contraindications to Augmentin for children: tablets - up to 12 years of age and body weight less than 40 kg; powder for preparation of suspension for oral administration of 400 mg / 57 mg and 200 mg / 28.5 mg - age up to 3 months.

In case of liver dysfunction, Augmentin should be taken with caution.

During pregnancy and breastfeeding, the attending physician decides whether to use the drug.

Instructions for the use of Augmentin: method and dosage

Before prescribing Augmentin, it is recommended to undergo an examination to determine the sensitivity of the microflora that caused the disease to this antibiotic. Next, the doctor sets the dosage regimen, taking into account the patient's age, weight, kidney function, and the severity of the disease.

The minimum effective course of treatment is 5 days, the maximum duration of therapy without adjusting the clinical situation is 2 weeks. The drug should be taken at the beginning of a meal.

If necessary, the first time the drug is administered parenterally, then oral administration can be prescribed.

Recommended doses when taking Augmentin tablets for children over 12 years old and adults:

• in case of infections of mild to moderate severity: 1 tablet (250 mg + 125 mg) 3 times a day;
• for severe or chronic infections: 1 tablet (500 mg + 125 mg) 3 times a day or 1 tablet (875 mg + 125 mg) 2 times a day.

Important: 2 tablets 250 mg / 125 mg are not equivalent to 1 tablet 500 mg / 125 mg.

Recommended doses when taking Augmentin suspension:

• children over 12 years old and adults: 11 ml of suspension 400 mg / 57 mg / 5 ml 2 times a day (corresponds to 1 tablet 875 mg + 125 mg);
• children from 3 months to 12 years old (weighing up to 40 kg): the daily dose is determined based on body weight and age (in ml - for suspension, or mg / kg / day). The calculated value should be divided into 3 doses with an 8-hour interval (for a suspension of 125 mg / 31.25 mg / 5 ml), or into 2 doses (for a suspension of 400 mg / 57 mg / 5 ml or 200 mg / 28.5 mg / 5 ml) at 12-hour intervals. For a suspension of 125 mg / 31.25 mg / 5 ml, low * doses - 20 mg / kg / day, high ** doses - 40 mg / kg / day. For a suspension of 400 mg / 57 mg / 5 ml and 200 mg / 28.5 mg / 5 ml, low doses - 25 mg / kg / day, high doses - 45 mg / kg / day.

* Low doses are used to treat recurrent tonsillitis and soft tissue and skin infections.

** High doses are required for the treatment of sinusitis, otitis media, joint and bone infections, urinary and respiratory tract infections.

Recommended doses of Augmentin in the form of a solution for intravenous administration (IV):

• children over 12 years old and adults: 1000 mg / 200 mg 3 times a day (every 8 hours); in severe infections, the interval between injections can be shortened to 4–6 hours;
• children from 3 months to 12 years: 3 times a day at the rate of 50 mg / 5 mg / kg or 25 mg / 5 mg / kg, depending on the severity of the infection, the interval between injections is 8 hours;
• children under the age of 3 months: with a body weight of more than 4 kg - 25 mg / 5 mg / kg or 50 mg / 5 mg / kg every 8 hours, with a body weight less than 4 kg - 25 mg / 5 mg / kg every 12 hours.

Augmentin should be taken strictly in the doses prescribed by the doctor, observing the prescribed regimen.

Side effects

The use of Augmentin in rare cases can cause the following (mainly mild and transient) side effects:

• hematopoietic system: thrombocytopenia, leukopenia (including neutropenia), hemolytic anemia and agranulocytosis (reversible), increased prothrombin index and bleeding time;
• immune system: allergic reactions in the form of anaphylaxis, angioedema, a syndrome similar to serum sickness, Stevens-Johnson syndrome, allergic vasculitis, toxic epidermal necrolysis, bullous exfoliative dermatitis, acute generalized exanthematous pustulosis. The use of Augmentin should be discontinued if any form of allergic dermatitis occurs;
• skin manifestations: rash, urticaria, erythema multiforme;
• central nervous system: hyperactivity and seizures (reversible), headache, dizziness;
• liver: cholestatic jaundice, hepatitis, moderate increase in ACT and / or ALT levels (these side effects occur during therapy or immediately after it, most often in elderly patients and in men (with long-term treatment), in children - very rare, and are reversible);
• urinary system: crystalluria, interstitial nephritis.

Very often, the use of Augmentin can cause diarrhea in adults and children, nausea, vomiting, dyspepsia (these digestive disorders can be reduced by taking the drug with meals).

Occasionally, in children who have taken Augmentin suspension, the color of the integumentary layer of the tooth enamel may change.

The microbiological effect of the drug often causes candidiasis of the mucous membranes, in rare cases it can cause hemorrhagic and pseudomembranous colitis.

Overdose

In case of an overdose of Augmentin, disturbances in the water-electrolyte balance and negative symptoms from the gastrointestinal tract can be observed. There are reports of the development of amoxicillin crystalluria, in some cases provoking the development of renal failure. Patients with renal dysfunction, as well as those taking high doses of the drug, may experience seizures.

To stop the negative phenomena associated with the functioning of the gastrointestinal tract, symptomatic therapy is prescribed, in the selection of which special attention should be paid to the normalization of the water-electrolyte balance. Clavulanic acid and amoxicillin can be removed from the systemic circulation through hemodialysis.

A prospective study at a poison control center, in which 51 children participated, confirms that the administration of amoxicillin in a dose not exceeding 250 mg / kg did not lead to the development of clinically significant symptoms of overdose and did not require gastric lavage.

After intravenous administration of amoxicillin in large doses, it can form a sediment in urinary catheters, so their patency should be checked regularly.

special instructions

With Augmentin therapy, it is necessary to collect a detailed history beforehand in order to find out whether there were any previous hypersensitivity reactions to cephalosporins, penicillins or other allergens.

Serious anaphylactoid reactions, sometimes fatal, have been reported in some cases. The risk of such conditions is especially high in patients with a history of hypersensitivity reactions to penicillins. If an allergic reaction occurs, Augmentin therapy should be stopped immediately, in severe cases, adrenaline should be administered immediately. There may be a need for oxygen therapy, intravenous glucocorticosteroids, and airway management, including intubation.

With prolonged use of Augmentin, the risk of excessive reproduction of microorganisms insensitive to it increases.

Influence on the ability to drive vehicles and complex mechanisms

Augmentin does not have a negative effect on the ability to drive vehicles and mechanisms.

Application during pregnancy and lactation

The results of studies of reproductive function in animals with parenteral and oral administration of Augmentin confirm the absence of teratogenic effects caused by the drug. A single study, which was conducted in patients with premature rupture of the membranes, suggests that prophylactic therapy with this antibiotic may increase the risk of necrotizing enterocolitis in newborns. Therefore, Augmentin should be used only in cases where the potential benefit of treatment for the mother significantly outweighs the potential adverse effects on the fetus.

The appointment of Augmentin during lactation is allowed. However, if children develop adverse reactions (candidiasis of the mucous membranes of the oral cavity, diarrhea, increased sensitization), it is recommended to stop breastfeeding.

Pediatric use

Allowed the appointment of Augmentin for children according to indications in compliance with the dosage regimen:

• powder for preparation of suspension for oral administration and powder for preparation of solution for intravenous administration - from birth;
• film-coated tablets - from 12 years old.

With impaired renal function

In patients with renal dysfunction, dose adjustment is based on the maximum therapeutic dose of amoxicillin and is carried out taking into account the values of creatinine clearance (CC).

When taken by adult patients in whom CC exceeds 30 ml / min, Augmentin tablets with a dosage of 500 mg / 125 mg or 250 mg / 125 mg, as well as a suspension with a dosage of 125 mg / 31.25 mg in 5 ml, there is no need for dose adjustment. If the CC value is from 10 to 30 ml / min, patients are recommended to take 1 tablet of 500 mg / 125 mg or 1 tablet of 250 mg / 125 mg (with mild and moderately severe infection) 2 times a day or 20 ml of a suspension of 125 mg / 31.25 mg in 5 ml 2 times a day.

With a CC value of less than 10 ml / min, Augmentin is used in a dosage of 1 tablet of 500 mg / 125 mg or 1 tablet of 250 mg / 125 mg (for mild and moderately severe infection) once a day or 20 ml of suspension 125 mg / 31.25 mg in 5 ml once a day.

Tablets 875 mg / 125 mg are prescribed only for patients with CC exceeding 30 ml / min, so no dose adjustment is required. In most cases, it is recommended to give preference to parenteral administration of Augmentin.

When used in adults and children over 12 years old or with a body weight of more than 40 kg who are on hemodialysis, the recommended dose of Augmentin is 1 tablet 500 mg / 125 mg (2 tablets 250 mg / 125 mg) once every 24 hours or 20 ml suspensions 125 mg / 31.25 mg once a day.

During the dialysis procedure, as well as at its end, the patient receives an additional one tablet (1 dose), which makes it possible to compensate for the decrease in the concentrations of clavulanic acid and amoxicillin in the blood serum.

For violations of liver function

Patients with liver dysfunction should be treated with caution. It is recommended to regularly monitor the condition of the liver. The limited data regarding the use of Augmentin in this category of patients does not allow the dosage regimen to be adjusted.

Use in the elderly

There is no need to reduce the dose for elderly patients: it is prescribed in the same doses as for adult patients. In elderly patients with renal dysfunction, the dose should be adjusted in the same way as for patients with renal insufficiency.

Drug interactions

Probenecid and drugs of similar action (phenylbutazone, diuretics, NSAIDs) reduce the tubular secretion of amoxicillin. Simultaneous administration is not recommended, since it may be accompanied by persistence and an increase in the concentration of amoxicillin in the blood (while the renal excretion of clavulanic acid does not slow down).

Taking Augmentin can affect the effect of oral contraceptives, reducing their effectiveness (the patient should be informed about this).

Augmentin in the form of a solution for injection cannot be mixed with aminoglycoside antibiotics in the same syringe, since in this case they lose their activity. It is also unacceptable to mix with infusion solutions containing dextran, dextrose and sodium bicarbonate. Do not mix with blood products, with other protein solutions (protein hydrolysates), with lipid emulsions for intravenous (IV) administration.

Analogs

Antibiotics with the same active ingredients: Amoxiclav, Arlet, Klamosar, Baktoklav, Verklav, Liklav, Panklav, Rapiklav, Ranklav, Medoklav, Flemoklav Solutab, Ekoklav, Fibell.

Augmentin's analogs by the mechanism of action, drugs of one pharmaceutical subgroup: Ampiox, Ampisid, Libakcil, Oxamp, Oxampicin, Oxamsar, Sulbatsin, Sultasin, Santaz, etc.

Terms and conditions of storage

Store at temperatures up to 25 ° C in a dry place out of the reach of children.

Shelf life:

• tablets containing amoxicillin 875 mg and 250 mg - 2 years;
• tablets containing amoxicillin 500 mg - 3 years;
• powder for preparation of solution for intravenous administration - 2 years;
• powder for preparation of suspension in unopened form - 2 years;
• prepared suspension (at a temperature in the range of 2–8 ° C) - 7 days.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Augmentin

Patients leave mostly positive reviews about Augmentin in the form of tablets and suspensions for children, describing them as effective and trustworthy. The average rating of a drug in specialized forums is 4.3-4.5 points out of 5. Many mothers are enthusiastic about the suspension, since it allows you to quickly and effectively cope with such frequent childhood diseases as tonsillitis or bronchitis. In addition, the suspension has a pleasant taste, thanks to which children really like it.

Also, the advantage of Augmentin is considered the possibility of its use in pregnant women, mainly in the II and III trimesters. Doctors say that during this period, for successful treatment, it is very important to observe the accuracy of the dosage and follow all the recommendations.

Price for Augmentin in pharmacies

Average price for Augmentin in the form of tablets: dosage of 875 mg / 125 mg - 355-388 rubles. per pack of 14 pcs., with a dosage of 500 mg / 125 mg - 305-421 rubles. per package 14 pcs.; dosage of 250 mg / 125 mg - 250-266 rubles. per package 20 pcs.

You can buy powder for preparation of a suspension for oral administration with a dosage of 125 mg / 31.25 mg in 5 ml for about 134-158 rubles, for a dosage of 200 mg / 28.5 mg in 5 ml - for 147-162 rubles, and a dosage of 400 mg / 57 mg in 5 ml - for 250-276 rubles.

Powder for the preparation of solution for intravenous administration is currently not commercially available.

Augmentin: prices in online pharmacies

Drug name Price Pharmacy

Augmentin 125 mg + 31.25 mg / 5 ml powder for suspension for oral administration 11.5 g (100 ml) 1 pc. RUB 58 Buy

Augmentin 200 mg + 28.5 mg / 5 ml powder for suspension for oral administration 7.7 g 1 pc. RUB 88 Buy

Augmentin powder for prig suspension for internal reception 125mg + 31.25mg / 5ml 11.5g 100ml 139 RUB Buy

Augmentin 400 mg + 57 mg / 5 ml powder for preparation of suspension for oral administration 12.6 g 1 pc. 141 r Buy

Augmentin pore. d / prigot. suspension d / int. reception 200mg + 28.5mg in 5ml fl. 7.7gx1 + measured. a spoon RUB 150 Buy

Augmentin 250 mg + 125 mg film-coated tablets 20 pcs. RUB 150 Buy

Augmentin 500 mg + 125 mg film-coated tablets 14 pcs. 162 RUB Buy

Augmentin powder for prig suspension for internal reception 400mg + 57mg / 5ml 12.6g 70ml 231 RUB Buy

Augmentin 875 mg + 125 mg film-coated tablets 14 pcs. 265 RUB Buy

Augmentin EC 600 mg + 42.9 mg / 5 ml powder for suspension for oral administration 23.13 g (100 ml) 1 pc. RUB 319 Buy

Augmentin tablets p.p. 875mg + 125mg 14 pcs. 322 RUB Buy

Augmentin CP 1000 mg + 62.5 mg film-coated tablets with modified release 28 pcs. 802 RUB Buy

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Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!