Mirofuril - Instruction, Application For Children, Suspension And Capsules, Price

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Mirofuril - Instruction, Application For Children, Suspension And Capsules, Price
Mirofuril - Instruction, Application For Children, Suspension And Capsules, Price

Video: Mirofuril - Instruction, Application For Children, Suspension And Capsules, Price

Video: Mirofuril - Instruction, Application For Children, Suspension And Capsules, Price
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Mirofuril

Mirofuril: instructions for use and reviews

  1. 1. Release form and composition
  2. 2. Pharmacological properties
  3. 3. Indications for use
  4. 4. Contraindications
  5. 5. Method of application and dosage
  6. 6. Side effects
  7. 7. Overdose
  8. 8. Special instructions
  9. 9. Application during pregnancy and lactation
  10. 10. Use in childhood
  11. 11. For violations of liver function
  12. 12. Drug interactions
  13. 13. Analogs
  14. 14. Terms and conditions of storage
  15. 15. Terms of dispensing from pharmacies
  16. 16. Reviews
  17. 17. Price in pharmacies

Latin name: Mirofuril

ATX code: A07AX03

Active ingredient: nifuroxazide (Nifuroxazide)

Manufacturer: ABC Pharmacy S.p. A. (ABC Farmaceutici SpA) (Italy)

Description and photo update: 09.10.2019

Prices in pharmacies: from 142 rubles.

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Suspension for oral administration Mirofuril
Suspension for oral administration Mirofuril

Mirofuril is a broad-spectrum antimicrobial agent, intestinal antiseptic.

Release form and composition

Dosage forms of Mirofuril:

  • capsules: hard gelatin, the body and cap of capsules with a dosage of 100 mg (size No. 2) - yellow, with a dosage of 200 mg (size No. 0) - white; the contents of the capsules are yellow powder, or yellow powder with small pieces of compressed mass, or pressed yellow powder, crumbling when lightly pressed (in blister strip packaging: dosage 100 mg - 10 pcs., in a cardboard box 1, 2, 3, 4 or 5 packs; dosage 200 mg - 7, 8 or 10 pcs., In a cardboard box 1, 2, 3, 4 or 5 packs);
  • suspension for oral administration: liquid mass of yellow color, has a banana smell (90 ml in glass bottles of dark color, in a cardboard box 1 bottle, complete with a polypropylene measuring cup).

Each pack also contains instructions for the use of Mirofuril.

1 capsule contains:

  • active substance: nifuroxazide - 100 or 200 mg;
  • auxiliary components: corn starch, sucrose, microcrystalline cellulose, magnesium stearate;
  • shell: gelatin, titanium dioxide (E171); additionally, in the capsule shell with a dosage of 100 mg - iron oxide yellow.

5 ml of suspension contains:

  • active substance: nifuroxazide - 200 mg;
  • auxiliary components: sucrose, ethanol 96%, citric acid, methyl parahydroxybenzoate, banana flavor, carbomer, 32% sodium hydroxide solution [pH (acidity) 5.2-5.8], purified water.

Pharmacological properties

Pharmacodynamics

Mirofuril is an antimicrobial drug with a wide spectrum of bacteriostatic action. When used in high doses, it has a bactericidal effect. Its active ingredient, nifuroxazide, is a 5-nitrofuran derivative. The antimicrobial activity of nifuroxazide is due to the presence of an NO2-group in its composition, which causes blocking of dehydrogenase activity, inhibition of the respiratory chain, tricarboxylic acid cycle and a number of other biochemical processes, which leads to disruption of protein synthesis in pathogenic bacteria.

Against the background of the use of the drug, the production of toxins by microorganisms decreases, the membranes of microbial cells are destroyed. Taking nifuroxazide does not lead to the emergence of resistant strains or cross-resistance with other antibacterial agents. The therapeutic effect of nifuroxazide does not depend on the pH in the intestinal lumen and the susceptibility of microorganisms to antibiotics.

The following pathogenic intestinal bacteria are highly sensitive to nifuroxazide: Staphylococcus speciales (spp.), Salmonella spp., Shigella spp., Campylobacter jejuni, Escherichia coli, Clostridium perfringens, Vibrions and Vibrio parahaemolyticlerae Vibrio.

Nifuroxazide exhibits weak activity against Enterobacter cloacae, Citrobacter spp., Proteus indologenes.

Klebsiella spp., Providencia spp., Proteus mirabilis, Pseudomonas spp. Are resistant to nifuroxazide.

In acute diarrhea of bacterial etiology, the drug helps to restore intestinal eubiosis. Prevents the development of bacterial superinfection when infected with enterotropic viruses.

Nifuroxazide does not affect the saprophytic flora and does not disturb the balance of the normal intestinal flora.

Pharmacokinetics

After oral administration, nifuroxazide is almost not absorbed from the digestive tract and does not enter the systemic circulation. The antibacterial effect is realized exclusively in the intestinal lumen. Completely excreted through the intestines (unchanged - 20%).

Indications for use

The use of Mirofuril is indicated for acute bacterial diarrhea, proceeding without an increase in body temperature, deterioration of the general condition and intoxication.

Contraindications

Absolute:

  • deficiency of sucrase and / or isomaltase, fructose intolerance, glucose-galactose malabsorption syndrome;
  • pregnancy;
  • neonatal period (up to 1 month), prematurity (oral suspension);
  • children under 3 years of age (capsules);
  • hypersensitivity to the components of the drug.

The use of capsules during lactation is indicated only with a temporary cessation of breastfeeding.

Care should be taken to take Mirofuril in the form of a suspension for alcoholism, liver dysfunction, brain diseases, traumatic brain injury, during lactation and childhood (over 1 month).

Mirofuril, instructions for use: method and dosage

Capsules

Mirofuril capsules are taken orally.

The duration of the course of therapy should not exceed 7 days.

Recommended dosage:

  • adults and children over 6 years old: 200 mg 4 times a day;
  • children 3-6 years old: 200 mg 3 times a day.

If after three days of treatment the patient's condition does not improve, it is necessary to consult a doctor.

Oral suspension

Suspension Mirofuril is taken orally, using a measuring cup for accurate dosing. Shake well before each use.

The same time interval should be observed between doses of a single dose.

It is recommended to start treatment for diarrhea in children under three years of age after consulting a doctor and under his supervision.

Recommended dosage of Mirofuril:

  • infants from 1 to 6 months: 2.5 ml (100 mg) 2-3 times a day;
  • children from 6 months to 3 years: 2.5 ml 3 times a day;
  • children from 3 to 6 years old: 5 ml (200 mg) 3 times a day;
  • children 6-18 years old: 5 ml 3-4 times a day;
  • adults: 5 ml 4 times a day.

The duration of the course of treatment is no more than 7 days.

If, after three days of taking the suspension, clinical improvement is not observed, you should seek medical help.

Side effects

In some cases, the use of Mirofuril can cause nausea, vomiting, the development of allergic reactions in the form of rash, urticaria, Quincke's edema or anaphylactic shock.

In addition, hypersensitivity reactions (symptoms - shortness of breath, itching, rash) may occur, requiring immediate discontinuation of the drug.

Overdose

Overdose symptoms have not been established.

Treatment: immediate gastric lavage, the appointment of symptomatic therapy.

special instructions

Treatment of diarrhea with Mirofuril must be accompanied by rehydration of the body using oral or intravenous therapy, depending on the patient's condition and the intensity of the diarrhea.

If side effects appear or worsen, you should consult a doctor.

The simultaneous use of alcohol or ethanol-containing drugs is contraindicated.

If bacterial diarrhea occurs with such signs of systemic damage as fever, deterioration of the general condition, symptoms of infection or intoxication, you should consult a doctor to prescribe antibacterial drugs of systemic action.

It should be borne in mind that the content of ethanol (in terms of absolute alcohol) and sucrose in 2.5 ml of suspension is, respectively, 0.019 g and 0.05 XE (bread unit), and in the maximum daily dose for adults (20 ml) - 0.152 g and 0.4 XE.

Influence on the ability to drive vehicles and complex mechanisms

Mirofuril capsules do not adversely affect the patient's ability to drive vehicles and mechanisms.

The effect of the suspension on psychomotor processes has not been studied, but drivers should take into account the ethanol content in its composition.

Application during pregnancy and lactation

The use of Mirofuril is contraindicated during the gestation period.

During lactation, the use of capsules is indicated only for strict indications with the simultaneous termination of breastfeeding.

Suspension Mirofuril during breastfeeding can be taken during a short course of treatment.

Pediatric use

It is contraindicated to take Mirofuril capsules for children under 3 years of age. Do not appoint Mirofuril suspension to children under 1 month of age, including premature babies.

The suspension should be used with caution to treat children over the age of 1 month.

For violations of liver function

The suspension should be taken with caution in patients with liver disease.

Drug interactions

It is not recommended to use Mirofuril simultaneously with drugs that inhibit the function of the central nervous system.

When combined with ethanol, a disulfiram-like reaction may occur, which is characterized by the following symptoms: headache, nausea, vomiting, weakness, abdominal pain, tachycardia, blurred vision, convulsions.

Patients who are on maintenance therapy with other drugs must first consult a doctor.

Analogs

Mirofuril's analogs are: Nifuroxazide, Adisord, KontrDiar, Nifural, Stopdiar, Enterofuril, Ersefuril, Ekofuril, Elufor, etc.

Terms and conditions of storage

Store in a dark place. Keep out of the reach of children.

Storage temperature: capsules - up to 25 ° C, suspension - from 15 to 25 ° C.

Shelf life: capsules - 3 years, suspension - 2 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Mirofuril

Reviews about Mirofuril are positive. Patients note the high efficacy of the drug in the treatment of dysbiosis, rotavirus infection. The advantages include fast action, the presence of two dosage forms, which makes it possible to use in babies, as well as the pleasant taste of the suspension.

The price of Mirofuril in pharmacies

The price for Mirofuril can be:

  • capsules: dosage of 100 mg - 195-249 rubles. (in the package 30 pcs.); dosage 200 mg - 238-265 rubles. (in the package 20 pcs.) or 269-349 rubles. (in the package 30 pcs.);
  • suspension for oral administration: 282–379 rubles. (in the package 1 bottle of 90 ml).

Mirofuril: prices in online pharmacies

Drug name

Price

Pharmacy

Mirofuril 200 mg capsules 14 pcs.

142 RUB

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Mirofuril 200 mg capsules 20 pcs.

184 r

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Mirofuril caps. 100mg 30 pcs.

201 RUB

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Mirofuril 100 mg capsules 30 pcs.

201 RUB

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Mirofuril 200 mg / 5 ml oral suspension 90 ml 1 pc.

239 r

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Anna Kozlova
Anna Kozlova

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!

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