Desloratadine Canon
Desloratadine Canon: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Desloratadine Canon
ATX code: R06AX27
Active ingredient: desloratadine (Desloratadine)
Producer: CJSC "Kanonfarma Production" (Russia)
Description and photo update: 2019-11-07
Prices in pharmacies: from 140 rubles.
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Desloratadine Canon is a long-acting antiallergic agent.
Release form and composition
Dosage form - film-coated tablets: almost white or white, round biconvex; the core in a cross section is white with a pinkish or creamy shade, or almost white (7 or 10 pieces in blisters, in a cardboard box from 1 to 3 packs; 30 pieces in a blister, in a cardboard box 1 or 2 Each pack also contains instructions for the use of Desloratadine Canon).
Composition of 1 tablet:
- active substance: desloratadine - 5 mg;
- auxiliary components: calcium hydrogen phosphate dihydrate - 61.7 mg; calcium stearate - 0.7 mg; povidone - 6.8 mg; microcrystalline cellulose - 41 mg; croscarmellose sodium - 4.8 mg;
- shell: Opadry II white (macrogol - 0.94 mg; polyvinyl alcohol - 1.88 mg; talc - 0.7 mg; titanium dioxide - 0.48 mg) - 4 mg.
Pharmacological properties
Pharmacodynamics
Desloratadine - the active substance of Desloratadine Canon, being the primary active metabolite of loratadine, is one of the long-acting antihistamines. Its effect is based on inhibition of the cascade of reactions of allergic inflammation: the release of pro-inflammatory cytokines (including interleukins IL-4, -6, -8 and -13); release of pro-inflammatory chemokines (RANTES); production of superoxide anions by activated polymorphonuclear neutrophils; adhesion and chemotaxis of eosinophils; release of adhesion molecules (such as P-selectin), IgE-mediated release of histamine, leukotriene C 4 and prostaglandin D 2… Thanks to the use of the drug, the development is prevented and the course of allergic reactions is facilitated. Desloratadine has an antipruritic and anti-exudative effect, helps to reduce capillary permeability, prevent smooth muscle spasm, tissue edema.
The substance does not affect the central nervous system, has practically no sedative effect (does not cause drowsiness), does not cause prolongation of the QT interval on the ECG, does not affect the speed of psychomotor reactions.
After oral administration, the effect of Desloratadine Canon develops within 30 minutes, its duration is 24 hours.
Pharmacokinetics
Desloratadine is well absorbed in the gastrointestinal tract. In blood plasma after oral administration is determined after 30 minutes. The average time to reach the maximum concentration of a substance is 3 hours. Desloratadine does not penetrate the blood-brain barrier. Binds to plasma proteins at the level of 83-87%. When used once a day at a dose of 5–20 mg in adolescents and adults for 14 days, there is no clinically significant cumulation of the drug. Food or grapefruit juice does not affect the distribution of desloratadine.
Desloratadine is not an inhibitor of CYP3A4 and C YP2D6, nor is it an inhibitor or substrate of P-glycoprotein. It undergoes intensive metabolism in the liver through hydroxylation, with the formation of a metabolite - 3-OH-desloratadine, combined with glucuronide. Only a small part of the dose is excreted by the kidneys and through the intestines (less than 2 and 7%, respectively). The half-life averages 27 hours (range 20 to 30 hours).
Indications for use
- allergic rhinitis: Desloratadine Canon is used to eliminate / relieve sneezing, nasal congestion, redness and itching of the eyes, watery eyes, nasal mucus, itching of the palate and nose;
- urticaria: used to reduce / eliminate itching, rash.
Contraindications
Absolute:
- pregnancy and the period of breastfeeding;
- age up to 12 years;
- hypersensitivity to the components of the drug.
In patients with severe chronic renal failure, with creatinine clearance (CC) less than 30 ml / min, Desloratadine Canon should be used under medical supervision.
Desloratadine Canon, instructions for use: method and dosage
Desloratadine Canon tablets are taken orally, regardless of food intake, preferably at the same time of day. The tablet must not be chewed, it must be swallowed whole and washed down with water.
The recommended dosage regimen for adults and children: 5 mg (1 tablet) per day, the duration of treatment depends on the severity of symptoms.
Recommended schemes for the use of Desloratadine Canon:
- intermittent seasonal allergic rhinitis (manifestation of symptoms no more than four days a week or their total duration no more than four weeks a year) and urticaria: an assessment of the course of the disease is required, if the symptoms disappear, Desloratadine Canon is discontinued, and if they reappear, they are resumed;
- persistent perennial allergic rhinitis (onset of symptoms more than four days a week or a total duration of more than four weeks a year): therapy can be continued throughout the exposure to allergens.
The duration of the course of therapy should be determined by the attending physician.
Side effects
Most often, in the course of clinical studies in adult patients, such adverse reactions were observed as headache - 0.6%, dry mouth - 0.8% and increased fatigue - 1.2%. In children and adolescents from 12 to 17 years old, complaints of headache were most often recorded - 5.9% (when taking placebo, this figure was higher - 6.9%).
The use of Desloratadine Canon can lead to the development of the following side effects [> 10% - very often; (> 1% and 0.1% and 0.01% and <0.1%) - rarely; <0.01% - very rare; unable to establish frequency from available data - frequency unknown]:
- skin and subcutaneous tissue: very rarely - rash; frequency unknown - photosensitivity;
- nervous system: infrequently - headache; very rarely - drowsiness / insomnia, psychomotor hyperreactivity, dizziness, convulsions;
- gastrointestinal tract: often - dry mouth; very rarely - nausea / vomiting, dyspepsia, abdominal pain, diarrhea;
- musculoskeletal system: very rarely - myalgia;
- immune system: very rarely - skin itching, rash (including urticaria), shortness of breath, angioedema, anaphylaxis;
- hepatobiliary system: very rarely - hepatitis; frequency unknown - jaundice;
- mental disorders: very rarely - hallucinations;
- heart: very rarely - palpitations, tachycardia; frequency unknown - prolongation of the QT interval;
- instrumental and laboratory data: very rarely - an increase in the concentration of bilirubin, an increase in the activity of liver enzymes;
- others: often - increased fatigue; frequency unknown - asthenia.
Overdose
The use of Desloratadine Canon in a dose 5 times higher than the recommended dose did not lead to the appearance of any symptoms. During clinical trials, the daily use of the drug at a dose of up to 20 mg for 14 days was not accompanied by clinically or statistically significant changes in the cardiovascular system. Taking a daily dose of 45 mg (9 times higher than the recommended dose) for 10 days did not lead to a prolongation of the QT interval and the appearance of serious side effects.
If you accidentally take a large number of Desloratadine Canon tablets, you should immediately consult a doctor.
Therapy: gastric lavage, the use of activated carbon; according to indications, symptomatic treatment is carried out. Desloratadine is not excreted during hemodialysis, the effectiveness of peritoneal dialysis has not been determined.
special instructions
The effectiveness of Desloratadine Canon in rhinitis of infectious genesis has not been studied.
In the course of clinical studies, the ineffectiveness of increasing the dose and more frequent administration of desloratadine has been proven, and therefore patients should be notified that the frequency of administration and dosage should not be increased.
Influence on the ability to drive vehicles and complex mechanisms
Taking desloratadine at the recommended dose does not adversely affect the patient's cognitive function. However, in some patients, in rare cases, during therapy, adverse reactions such as drowsiness and dizziness are noted. This can affect the speed of psychomotor reactions and the ability to concentrate, making it difficult to drive vehicles and work with complex mechanisms.
Application during pregnancy and lactation
Desloratadine Canon is not prescribed during pregnancy / lactation.
Pediatric use
For patients under 12 years of age, Desloratadine Canon is contraindicated.
With impaired renal function
In patients with severe chronic renal failure, therapy should be carried out with caution.
Drug interactions
Interaction of Desloratadine Canon with other drugs / substances, including ethanol, has not been identified.
Analogs
Analogs of Desloratadine Canon are Blogir-3, Alestamine, Desloratadin, Desal, Lordestin, Delorsin, Elisey, Erius, Eslotin, Ezlor, etc.
Terms and conditions of storage
Store at temperatures up to 25 ° C in a place protected from light and moisture. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Desloratadine Canon
Reviews of Desloratadine Canon characterize the drug as effective and inexpensive. Also, the advantages include a convenient dosing regimen and good tolerance.
The price of Desloratadine Canon in pharmacies
Approximate price for Desloratadine Canon, film-coated tablets, 5 mg, 10 pcs. in the package is 143-290 rubles.
Desloratadine Canon: prices in online pharmacies
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Drug name Price Pharmacy |
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Desloratadine Canon 5 mg film-coated tablets 10 pcs. 140 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
