Dibikor
Dibikor: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Dibicor
ATX code: C01EB
Active ingredient: taurine (taurine)
Producer: Technologist SKTB St. Petersburg Technological Institute (Russia), Pik-Pharma PRO (Russia), Pik-Pharma LEK, LLC (Russia)
Description and photo update: 2019-20-08
Prices in pharmacies: from 220 rubles.
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Dibikor is a drug that improves metabolism and energy supply to tissues.
Release form and composition
It is produced in tablets: flat-cylindrical, white or almost white, with a line and a chamfer (250 mg - 10 pcs. In blister contour packs, in a cardboard pack 3 or 6 packs; 30 or 60 pcs. In dark glass jars, in pack of cardboard 1 can; 500 mg - 10 pcs. in blister strip packs, in a pack of cardboard 3 or 6 packs).
Active ingredient: taurine, in 1 tablet - 250 or 500 mg.
Auxiliary components: potato starch, microcrystalline cellulose, calcium stearate, colloidal silicon dioxide (aerosil), gelatin.
Pharmacological properties
Pharmacodynamics
Taurine, the active substance of Dibikor, is a natural metabolic product of sulfur-containing amino acids: cysteamine, cysteine, methionine. It has osmoregulatory and membrane-protective efficacy, has a positive effect on the phospholipid composition of cell membranes, and helps to normalize the exchange of potassium and calcium ions in cells.
It has the properties of an inhibitory neurotransmitter, has an antioxidant and antistress effect, regulates the release of GABA (gamma-aminobutyric acid), prolactin, adrenaline and other hormones, as well as responses to them. It takes part in the synthesis of proteins of the respiratory chain in mitochondria, is necessary for oxidative processes, affects the enzymes responsible for the metabolism of various xenobiotics.
In patients with diabetes mellitus, about 2 weeks after starting therapy, a decrease in blood glucose levels is observed. There was also a significant decrease in the concentration of triglycerides, to a somewhat lesser extent - atherogenicity of plasma lipids, cholesterol levels. With a long course (about six months), there is an improvement in the microcirculatory blood flow of the eye.
Other effects of Dibikor:
- improvement of metabolic processes in the liver, heart and other tissues and organs;
- an increase in blood flow and a decrease in the severity of cytolysis against the background of chronic diffuse liver diseases;
- reduction of congestion in the small / large circles of blood circulation in cardiovascular failure, which manifests itself in the form of a decrease in intracardiac diastolic pressure, an increase in myocardial contractility;
- reduction of hepatotoxicity of antifungal drugs in combination with the use;
- moderate decrease in blood pressure with arterial hypertension, while in patients with cardiovascular insufficiency with low blood pressure levels, this effect is absent;
- a decrease in the severity of side reactions caused by an overdose of cardiac glycosides and blockers of slow calcium channels;
- increase in performance during heavy physical exertion.
Pharmacokinetics
After a single dose of Dibikor in a dose of 500 mg, taurine is determined in the blood after 15–20 minutes. C max (maximum concentration) is achieved in 1.5–2 hours. After 24 hours, the drug is excreted from the body in full.
Indications for use
- Type 1 diabetes mellitus;
- Type 2 diabetes mellitus, including those accompanied by hypercholesterolemia;
- Cardiovascular insufficiency of various origins;
- Intoxication caused by cardiac glycosides.
As a hepatoprotective agent, Dibikor is prescribed to patients taking antifungal drugs.
Contraindications
Individual hypersensitivity to the components of the drug is the main contraindication to Dibikor.
Due to the lack of clinical data on the safety of use, the drug is not prescribed to patients under the age of 18 years.
Instructions for the use of Dibikor: method and dosage
Dibikor should be taken orally.
Recommended treatment regimens depending on the indications:
- Heart failure: 250-500 mg 2 times a day 20 minutes before meals, the duration of therapy is at least 30 days. If necessary, the daily dose is increased to 2000-3000 mg;
- Intoxication with cardiac glycosides: at least 750 mg per day;
- Diabetes mellitus type 1: 500 mg 2 times a day in combination with insulin. The course of treatment is 3-6 months;
- Diabetes mellitus type 2: 500 mg 2 times a day as a monotherapy or in combination with other oral hypoglycemic agents;
- As a hepatoprotective drug: 500 mg 2 times a day during the entire period of use of antifungal agents.
Side effects
Allergic reactions to Dibikor components.
Overdose
There is no information.
special instructions
Patients receiving Dibicor and taking cardiac glycosides need to reduce the dose of the latter, depending on the sensitivity of patients to cardiac glycosides (sometimes a 2-fold dose reduction may be required). A similar requirement applies to slow calcium channel blockers.
Application during pregnancy and lactation
There is no information on the safety and efficacy of the drug by pregnant and lactating women.
Pediatric use
According to the instructions, Dibikor is not used in pediatric practice.
Drug interactions
Taurine enhances the inotropic effect of cardiac glycosides.
If necessary, Dibikor can be used in combination with other drugs.
Analogs
Dibikor's analogs are: Taufon, ATP-long, Tauforin OZ, Tincture of hawthorn, ATP-Forte, Vasonat, Ivab-5, Kapikor, Carduktal, Cardioactive Taurin, Mexicor, Metamax, Metonat, Mildrocard, Milkardin, Neocardin, Ribodil, Tricard, Trizipin, Trimet, Vasopro, Mildrazin, Mildronat.
Terms and conditions of storage
Store at temperatures up to 25 ºС in a dry, dark place out of reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Dibikor
According to reviews, Dibikor is an affordable and effective remedy. Indicate that the drug has good tolerance, quickly normalizes sugar, improves performance, improves memory and well-being. Some patients are unhappy with the size of the tablets, which makes it difficult for them to swallow.
Dibikor price in pharmacies
The approximate price for Dibikor (60 tablets of 250 or 500 mg) is 248-294 or 429-480 rubles.
Dibikor: prices in online pharmacies
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Drug name Price Pharmacy |
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Dibikor 250 mg tablets 60 pcs. 220 RUB Buy |
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Dibikor tablets 250mg 60 pcs. 253 r Buy |
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Dibikor 500 mg tablets 60 pcs. RUB 300 Buy |
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Dibikor tablets 500mg 60 pcs. 455 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
