Miropriston - Instructions For The Use Of Tablets, Reviews, Price, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Miropristone

Miropriston: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. In case of impaired renal function
11. 11. For violations of liver function
12. 12. Use in the elderly
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Miropristone

ATX code: G03XB01

Active ingredient: Mifepristone (Mifepristone)

Producer: Obninsk Chemical and Pharmaceutical Company (Russia)

Description and photo update: 2018-26-10

Prices in pharmacies: from 1459 rubles.

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Miropristone is an antigestagen.

Release form and composition

Dosage form - tablets: flat-cylindrical, chamfered and scored, light yellow or light yellow with a greenish tinge (2, 3 or 6 pcs. In polymer cans; 2 or 3 pcs. In blisters, in cardboard pack 1 or 2 packs).

Composition of 1 tablet:

• active substance: mifepristone - 200 mg;
• additional components: sodium carboxymethyl starch, calcium stearate, talc, microcrystalline cellulose.

Pharmacological properties

Pharmacodynamics

Mifepristone - the active substance of Miropristone - is a synthetic steroidal antigestagenic agent (it blocks the action of progesterone at the receptor level), which does not possess gestagenic activity.

Increases the contractility of the myometrium, stimulates the release of interleukin-8 in choriodecidual cells, increases the sensitivity of the myometrium to prostaglandins.

Miropristone promotes desquamation (flaking) of the decidua and the removal of the ovum.

Due to competition at the level of binding to receptors, mifepristone has antagonism with glucocorticosteroids.

Pharmacokinetics

After a single oral dose of 600 mg mifepristone, a maximum concentration of 1.98 mg / L is reached after 1.3 hours. Absolute bioavailability - 69%.

Mifepristone has a high binding to plasma proteins (98%), namely acid alpha1-glycoprotein and albumin.

After the distribution phase, excretion begins slowly, in the period between 12–72 hours, the concentration decreases by 2 times, then the rate of excretion increases.

The half-life is 18 hours.

Indications for use

• termination of uterine pregnancy in the early stages (up to 42 days of amenorrhea) - Miropristone is used in combination with misoprostol;
• preparation and induction of labor.

Contraindications

• uterine fibroids;
• the presence of severe extragenital pathology;
• acute inflammatory diseases of the female genital organs;
• disorders of hemostasis (including previous treatment with anticoagulants);
• anemia (hemoglobin level less than 100 g / l);
• acute or chronic renal and / or hepatic failure;
• adrenal insufficiency;
• porphyria;
• long-term glucocorticosteroid therapy;
• smoking over the age of 35 without first consulting a therapist;
• a history of hypersensitivity to mifepristone.

Additional contraindications for medical abortion:

• pregnancy exceeding 42 days of amenorrhea;
• pregnancy not confirmed by clinical trials;
• suspicion of an ectopic pregnancy;
• pregnancy that occurs during the use of an intrauterine contraceptive or after the cancellation of hormonal contraception.

Additional contraindications for preparation and induction of labor:

• bloody discharge from the genital tract of unspecified etiology during pregnancy;
• eclampsia;
• preeclampsia;
• severe gestosis;
• premature or post-term pregnancy;
• abnormal position of the fetus;
• premature rupture of amniotic fluid;
• discrepancy between the size of the mother's pelvis and the fetal head;
• severe forms of hemolytic disease of the fetus.

According to the instructions, Miropriston should be used with caution in the following cases:

• heart failure;
• heart rhythm disturbances;
• arterial hypertension;
• bronchial asthma;
• obstructive pulmonary disease.

Instructions for the use of Miropriston: method and dosage

Miropriston tablets are used only in medical institutions equipped with the necessary equipment, under the close supervision of a qualified doctor.

Early medical termination of pregnancy

In the presence of a doctor, a woman drinks 3 tablets once (600 mg of mifepristone in total) with 100 ml of boiled water. The drug should be taken 1–1.5 hours after a light breakfast. After 36–48 hours, the patient must report to the medical facility to receive misoprostol at a dose of 0.4 mg, after which she remains under dynamic medical supervision for 2 hours.

After 10-14 days, the woman undergoes a clinical and ultrasound examination, if necessary, the level of chorionic gonadotropin is determined to confirm that the pregnancy has ended.

If after 14 days the effect of the drug is absent (i.e. the pregnancy persists or an incomplete abortion has occurred), mandatory vacuum aspiration and subsequent histological examination of the aspirate are indicated.

Preparation and induction of labor

In the presence of a doctor, a woman takes 1 tablet of Miropriston once, after 24 hours, the reception is repeated. After another 48–72 hours, the condition of the birth canal is assessed, if necessary, oxytocin or prostaglandins are prescribed.

Side effects

Miropristone can cause the following side effects: headache, general weakness, dizziness, hyperthermia, nausea and vomiting, discomfort in the lower abdomen, urticaria.

The procedure for medical abortion can be accompanied by pain in the lower abdomen and bloody discharge from the genital tract. It is also possible to exacerbate the inflammatory processes of the uterus and appendages.

Overdose

When taken in doses up to 2000 mg, mifepristone does not cause adverse events.

In case of an overdose of the drug, there is a risk of developing adrenal insufficiency.

special instructions

The drug can be supplied only to specialized obstetric and gynecological institutions related to the state health care system, as well as to private and municipal institutions that have an appropriate license to carry out this type of activity.

The use of Miropriston requires the prevention of Rh alloimmunization and other measures associated with abortion.

Every woman who is prescribed Miropristone to terminate a pregnancy should be warned that if a miscarriage does not occur after 10-14 days, the pregnancy must be terminated in a different way, because after the use of mifepristone, the risk of congenital malformations in the fetus is extremely high.

Application during pregnancy and lactation

In the early stages of pregnancy, Miropriston is used to terminate it, in late pregnancy - for the preparation and induction of labor.

Mifepristone, used to prepare the cervix for childbirth, does not affect subsequent lactation.

In the case of medical abortion during lactation, breastfeeding should be stopped for 3 days.

With impaired renal function

In chronic and acute renal failure, the use of Miropriston is contraindicated.

For violations of liver function

In chronic and acute hepatic failure, the use of Miropriston is contraindicated.

Use in the elderly

The drug is not used in elderly patients.

Drug interactions

Mifepristone reduces the effect of glucocorticosteroid drugs, therefore, an increase in their dose is required when using such a combination.

It is not recommended to take non-steroidal anti-inflammatory drugs simultaneously with mifepristone.

Analogs

The analogues of Miropriston are: Agesta, Ginepristone, Ginestril, Zhenale, Mifegin, Mifeprex, Mifepristone, Mifolian, Pencrofton.

Terms and conditions of storage

The shelf life is 5 years.

Store at a temperature not exceeding 30 ° C in a dark, dry place out of reach of children.

Terms of dispensing from pharmacies

For hospitals.

Reviews about Miropriston

Most of the reviews about Miropriston are positive. Women confirm the high efficacy of the drug both in early medical abortion and in the stimulation of labor (usually in case of prolonged pregnancy).

However, there are also individual reviews in which women share their unsuccessful experience with this drug. Most often we are talking about abortion. Patients indicate either pronounced side effects of Miropriston, or a complete lack of effect, which led to the need for vacuum aspiration.

The price of Miropriston in pharmacies

The average price for Miropriston is 2235 rubles. per pack of 3 tablets.

Miropriston: prices in online pharmacies

Drug name Price Pharmacy

Miropriston 200 mg tablets 3 pcs. 1459 RUB Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!