Indocollir
Indocollir: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacodynamics and pharmacokinetics
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Drug interactions
- 10. Analogs
- 11. Terms and conditions of storage
- 12. Terms of dispensing from pharmacies
- 13. Reviews
- 14. Price in pharmacies
Latin name: Indocollyre
ATX code: S01BC01
Active ingredient: Indomethacin (Indometacin)
Manufacturer: Laboratoire CHAUVIN (France)
Description and photo update: 2019-06-08
Prices in pharmacies: from 250 rubles.
Buy
Indocollir is a non-steroidal anti-inflammatory drug (NSAID) for topical use in ophthalmology.
Release form and composition
Dosage form - eye drops 0.1%: a transparent almost colorless sterile solution (5 ml in a polyethylene dropper bottle, 1 bottle in a cardboard box).
The active substance is indomethacin, in 1 ml of solution - 1 mg.
Auxiliary components: thiomersal, hydroxypropyl betacyclodextrin, hydrochloric acid, arginine, purified water.
Pharmacodynamics and pharmacokinetics
Indomethacin, the active component of the drug, inhibits the synthesis of prostaglandins, eliminating pain and stopping the inflammatory process by reducing the activity of the enzyme cyclooxygenase. This substance is a non-steroidal anti-inflammatory agent, which, when applied topically, reduces the intensity of inflammation and the severity of pain by suppressing the production and transmission of pain impulses through nerve cells. Indomethacin also inhibits the synthesis of thromboxane type A, which leads to an increase in bleeding time.
The results of clinical studies indicate that indomethacin penetrates into the anterior chamber of the eye. With a single instillation, the active component of the drug is found in the moisture of the anterior chamber for several hours.
With local application of the drug, its systemic absorption is negligible.
Indications for use
- Inhibition of miosis during cataract surgery;
- Prevention and treatment of inflammatory processes in the eyeball after surgery;
- Prevention of cystic macular edema after cataract surgery;
- Treatment of conjunctivitis of non-infectious genesis;
- Prevention and treatment of inflammatory processes against the background of penetrating and non-penetrating injuries of the eyeball as part of a comprehensive local antimicrobial therapy.
Contraindications
- Breastfeeding period;
- From 6 to 9 months of pregnancy;
- Hypersensitivity to NSAIDs, including acetylsalicylic acid, manifested by acute rhinitis, attacks of bronchial asthma, urticaria;
- Hypersensitivity to drug components.
It is recommended to use Indocollir with caution in patients with hemophilia, a tendency to bleeding and other diseases that cause blood clotting disorders and prolonged bleeding time; epithelial herpetic keratitis (including history); severe liver dysfunction.
The prescription of the drug during the first 5 months of pregnancy is made only if the intended benefits of the treatment for the mother outweigh the potential harm and risk to the child.
Instructions for the use of Indocollir: method and dosage
Indocollir eye drops are instilled into the conjunctival sac of the eye.
The drug is prescribed in 1 drop, the frequency of instillation depends on the clinical indications and the severity of the condition, and can be 3 to 4 times a day, for 1-4 weeks.
To inhibit miosis during surgery, the drug should be instilled 2 hours before surgery, 1 drop at 30-minute intervals, 4 drops in total.
For the prevention of cystic edema of the macula, the drug is prescribed 1 drop 3-4 times a day. The course of therapy after the operation is 1 month.
Side effects
- From the side of the organ of vision: rarely - mild or moderate burning sensation, temporary loss of clarity of vision immediately after instillation; with prolonged use - conjunctivitis, corneal opacity;
- Allergic reactions: rarely - redness and itching of the skin;
- Others: with prolonged use - the development of side effects of systemic indomethacin.
Overdose
With accidental oral administration of eye drops, unwanted side effects do not develop.
special instructions
Patients with contact lenses before instillation should remove the lenses and reinstall them no earlier than 15 minutes after the procedure.
After each use of the drug, the bottle must be tightly closed. Do not allow the pipette tip to touch the eye or other objects.
Patients in whom the action of drops causes a temporary loss of vision clarity, immediately after instillation of the drug, should refrain from driving vehicles and mechanisms or from working with complex machinery and equipment.
Drug interactions
According to the instructions, Indocollir is not recommended for use in combination with other NSAIDs, including acetylsalicylic acid in high doses (3 g or more per day); diflunisal (due to the risk of bleeding in the gastrointestinal tract).
The drug can enhance the effect of lithium preparations, indirect anticoagulants.
While taking indomethacin, it can weaken the therapeutic effect of beta-blockers, saluretics.
If necessary, the drug can be used in combination with other eye drops, including those containing glucocorticosteroids, observing the interval between instillations of at least 5 minutes.
Analogs
Indocollir analogues are: Indomethacin, Indomethacin-Health, Metindol, Akuvayl, Nevanak, Uniclofen.
Terms and conditions of storage
Store at temperatures up to 25 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Indocollire
Despite the average cost of the drug and the inability to purchase it in pharmacies without a prescription, the reviews about Indocollir are quite numerous and contradictory. Some patients claim that after using the drops they faced such unpleasant side effects as redness and burning sensation in the eye area, other patients note the high efficacy of the drug as an analgesic and anti-inflammatory agent for various ophthalmic diseases and mechanical eye injuries.
Price for Indocollir in pharmacies
The average price of Indocollir in pharmacies is 330–370 rubles (for a 5 ml bottle).
Indocollir: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Indocollyr 0.1% eye drops 5 ml 1 pc. RUB 250 Buy |
|
Indocollyr eye drops 1mg / ml 5ml 466 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
