Indinol Forto - Instructions For Use, Reviews, Price, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Indinol Forto

Indinol Forto: instructions for use and reviews

1. 1. Form of release and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Indinol Forto

ATX code: G03XC

Active ingredient: Indolcarbinol (Indolcarbinol)

Producer: CJSC "MiraxBioFarma" (Russia)

Description and photo update: 06.06.2018

Prices in pharmacies: from 2184 rubles.

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Indinol Forto - a selective estrogen receptor modulator; metabolic agent.

Form of release and composition

Dosage form - capsules: size No. 0, gelatinous solid, with an orange cap and a white body; content - powder from white to light brown or light yellow (20 pcs. in blister strip packaging, in a cardboard box 3 or 6 packs; 60, 90 and 120 pcs. in polymer cans with first opening control, in a cardboard box pack of 1 can).

Composition of 1 capsule:

• active substance: indole carbinol - 200 mg;
• additional components: modified corn starch, lactose monohydrate (milk sugar), magnesium stearate, microcrystalline cellulose.

Pharmacological properties

Pharmacodynamics

The active substance of Indinola Forto is indolecarbinol - a universal corrector of pathological hyperplastic processes in the tissues of the mammary gland. It has antiproliferative and antiestrogenic effects. The main property of the drug is its ability to induce selective death of breast cells with abnormally high proliferative activity.

Indolecarbinol modulates the cytochrome system, resulting in the formation of the cytochrome P450 isoform, CYP1A1, which hydroxylates estrogens in the second position. The resulting metabolite, 2-hydroxyestrone (2-OHE1), is an antagonist of the estrogen receptor and blocks its activation by estrogens themselves and their dangerous metabolites, including 16-α-hydroxyestrone (16α-OHE1). Thus, the induction of estrogen-dependent genes is suppressed, and the cell stops receiving overstimulation.

Indinol Forto also blocks other signaling mechanisms (cytokine), which, by suppressing signaling cascades from the corresponding receptors, stimulate pathological cell growth in breast tissues.

The drug reduces the intensity of pain or relieves pain in the mammary gland with cyclic mastalgia (mastodynia).

Indinol Forto does not contribute to an increase in body weight; it belongs to practically non-toxic drugs (LD ₅₀ > 5 g / kg).

Indications for use

According to the instructions, Indinol Forto is used for cyclic mastalgia (mastodynia), including those developed as a result of benign breast hyperplasia.

Contraindications

• glucose-galactose malabsorption;
• lactase deficiency;
• hereditary galactose intolerance;
• children and adolescents up to 18 years old;
• pregnancy;
• breast-feeding;
• hypersensitivity to drug components.

Instructions for the use of Indinola Forto: method and dosage

Indinol Forto is indicated for oral administration, before meals.

Adult women are prescribed 1 capsule 2 times a day.

The duration of treatment is 6 months.

Side effects

• from the digestive system: pain in the epigastric region;
• from the reproductive system: violation of the menstrual cycle (lengthening or shortening);
• laboratory parameters: eosinophilia, a decrease in the concentration of creatinine, an increase in the concentration of estradiol, prolactin, follicle-stimulating and thyroid-stimulating hormones;
• other: weight loss.

According to the data of clinical studies, the incidence of side effects in patients receiving Indinol Forto was approximately comparable to that in women receiving placebo (26.9% and 20%, respectively). The undesirable reactions that arose were of a mild nature, passed on their own or were stopped by the appointment of symptomatic agents.

Overdose

In case of overdose, diarrhea, nausea and vomiting may occur.

The specific antidote for indolecarbinol is unknown. Treatment is symptomatic.

special instructions

If any of the side effects indicated in the instructions are aggravated, or other undesirable reactions have occurred, you should inform your doctor about this.

Influence on the ability to drive vehicles and complex mechanisms

Given the peculiarities of the pharmacodynamics of indolecarbinol and the profile of its undesirable effects, it is unlikely that the drug has a negative effect on concentration, mental and physical reactions.

Application during pregnancy and lactation

During pregnancy and lactation, the use of the drug Indinol Forto is contraindicated.

Pediatric use

For patients under the age of 18, the appointment of Indinola Forto is contraindicated.

Drug interactions

Indolecarbinol affects the activity of cytochrome P ₄₅₀ isoenzymes, therefore, caution is required and, if necessary, dose adjustment in case of simultaneous use of drugs metabolized with the participation of this system, such as antiarrhythmic and antiepileptic drugs, oral hypoglycemic drugs, digitalis drugs, glucocorticosteroids, indirect anticoagulants hormones.

Analogs

An analogue of Indinol Forto is the drug Indoprolone.

Terms and conditions of storage

Shelf life is 2 years.

Keep out of the reach of children, protected from light and moisture, at temperatures up to 25 ° C.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Indinole Forto

Reviews about Indinole Forto are controversial. Some women write that the drug is really effective: it relieves pain in mastodynia and prevents the growth of fibroadenomas, while not causing side effects. Others, on the contrary, point to the lack of a therapeutic effect in their case and the occurrence of undesirable reactions.

Almost all patients note the high cost of the drug, which is especially noticeable when undergoing a full 6-month course of treatment.

The price of Indinol Forto in pharmacies

The approximate price for Indinol Forto is 2,415-2,900 for a package of 60 capsules.

Indinol Forto: prices in online pharmacies

Drug name Price Pharmacy

Indinol Forto 200 mg capsules 60 pcs. 2184 RUB Buy

Indinol Forto capsules 200mg 60 pcs. 2250 RUB Buy

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!