Berlition
Berlition: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Drug interactions
- 10. Analogs
- 11. Terms and conditions of storage
- 12. Terms of dispensing from pharmacies
- 13. Reviews
- 14. Price in pharmacies
Latin name: Berlithion
ATX code: A16AX01
Active ingredient: Thioctic acid (Thioctic acid)
Producer: Jenahexal Pharma, EVER Pharma Jena GmbH, Haupt Pharma Wolfratshausen (Germany)
Description and photo update: 2019-12-08
Prices in pharmacies: from 496 rubles.
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Berlition is a drug that regulates metabolism.
Release form and composition
Berlition is available in the following dosage forms:
- Concentrate for the preparation of a solution for infusion: greenish-yellow, transparent (Berlition 300: 12 ml in dark glass ampoules, 5, 10 or 20 ampoules in cardboard trays, 1 tray in a cardboard box; Berlition 600: 24 ml in each dark glass ampoules, 5 ampoules in plastic pallets, 1 pallet in a cardboard box);
- Film-coated tablets: round, biconvex, on one side - risk, pale yellow color, a granular uneven surface is visible on the cross-section (10 pcs. In blisters, 3,6,10 blisters in a cardboard box).
The main active ingredient is thioctic acid:
- In 1 ampoule of concentrate - 300 mg or 600 mg;
- 1 tablet contains 300 mg.
Pharmacological properties
Pharmacodynamics
Thioctic (alpha lipoic) acid is an endogenous antioxidant with direct (free radical scavenging) and indirect action. It belongs to a group of coenzymes involved in the decarboxylation reactions of alpha-keto acids. This compound helps to lower the level of glucose in the blood plasma and increase the concentration of glycogen in the liver, reduces insulin resistance, takes part in the regulation of lipid and carbohydrate metabolism, and also intensifies cholesterol metabolism.
Since thioctic acid has antioxidant properties, it protects cells from destruction by their decay products, inhibits the production of end products of progressive glycosylation of proteins in nerve cells, which is accompanied by diabetes mellitus, improves endoneural blood flow and microcirculation, and increases the physiological concentration of the antioxidant glutathione. Providing a decrease in the glucose content in blood plasma, the active component of Berlition affects the alternative glucose metabolism in diabetes mellitus, minimizes the accumulation of pathological metabolites in the form of polyols and, as a result, reduces the edema of the nervous tissue.
Thioctic acid is involved in the metabolism of fats, which causes an increase in the biosynthesis of phospholipids, in particular, phosphoinositides, resulting in the normalization of the damaged structure of cell membranes. Also, the substance improves the conduction of nerve impulses and energy metabolism, allows you to get rid of the toxic effects of alcohol metabolites (pyruvic acid, acetaldehyde). Thioctic acid prevents the formation of excess molecules of free oxygen radicals, eliminates ischemia and endoneural hypoxia, alleviating the symptoms of polyneuropathy, which are expressed in sensations of numbness, pain or burning in the extremities, as well as paresthesias. Thus, this substance improves lipid metabolism and is characterized by neurotrophic and antioxidant effects. The use of thioctic acid in the form of ethylenediamine salt leads to a decrease in the severity of possible side effects.
Pharmacokinetics
With intravenous administration of Berlition, the maximum concentration of the active substance in the blood plasma is approximately 20 μg / ml 30 minutes after infusion, and the area under the concentration-time curve is approximately 5 μg / h / ml. Thioctic acid has a "first pass" effect through the liver. Its metabolites are formed by conjugation and oxidation of the side chain. The volume of distribution is approximately 450 ml / kg. The total plasma clearance is 10-15 ml / min / kg. Thioctic acid is excreted through the kidneys (80–90%), mainly in the form of metabolites. The half-life is about 25 minutes.
Indications for use
According to the instructions, Berlition is used to treat alcoholic and diabetic polyneuropathy.
Contraindications
The use of Berlition is contraindicated in children under 18 years of age, women during pregnancy and lactation, as well as patients who have hypersensitivity to the components of the drug.
The drug is prescribed with caution in patients with diabetes mellitus.
Instructions for the use of Berlition: method and dosage
The drug is usually taken once a day, in the morning, half an hour before breakfast. Berlition tablets cannot be chewed or crushed. The daily dose for adults is 600 mg (2 tablets).
The drug in the form of a concentrate, diluted with 0.9% sodium chloride solution, is injected drip, 250 ml for half an hour. The daily dose for adult patients is 300-600 mg. The introduction of Berlition intravenously is usually carried out for 2-4 weeks, after which the patient is transferred to receive the drug orally.
Side effects
The use of Berlition can cause a number of side effects, such as: stool disturbance, changes in taste, nausea and vomiting, dyspeptic symptoms, convulsions, headache, tachycardia, chest pain, various allergic reactions, visual impairment.
Overdose
Signs of an overdose of Berlition include nausea, vomiting, headache. In this case, symptomatic treatment is recommended. There is no specific antidote.
special instructions
During the course of treatment, you should stop drinking alcoholic beverages, since ethanol reduces the effectiveness of thioctic acid.
Patients with diabetes mellitus need to constantly monitor their blood glucose levels.
Eating dairy products, as well as taking magnesium and iron supplements during treatment, should be in the afternoon.
When the drug is taken together with oral hypoglycemic agents and insulin, the effect of the latter is enhanced.
Influence on the ability to drive vehicles and complex mechanisms
Studies to study the effect of Berlition on the speed of psychomotor reactions and the ability to perceive and quickly assess extraordinary situations have practically not been carried out, therefore, during treatment with the drug, special care should be taken when driving a car and performing potentially hazardous types of work that require increased concentration and concentration.
Drug interactions
Since the formation of chelate complexes of thioctic acid with metals is quite possible, Berlition should not be prescribed in conjunction with iron preparations. The combination of a drug with cisplatin reduces the effectiveness of the latter.
Thioctic acid combines with sugar molecules, forming complex compounds that are practically unable to dissolve. Berlition is forbidden to use against the background of treatment with Ringer's solution, solutions of dextrose, fructose and glucose, as well as solutions interacting with disulfide and SH-groups. The drug enhances the hypoglycemic effect of insulin and other hypoglycemic drugs when used simultaneously. Ethanol significantly weakens the therapeutic efficacy of Berlition.
Analogs
Structural analogues of Berlition are the drugs Espa-Lipon, Octolipen, Tiogamma, Lipothioxon, Tiolipon and Neurolipon.
Storage conditions and periods
Store at a temperature not exceeding 25 ° C.
Shelf life: tablets - 2 years, concentrate - 3 years. The prepared solution of the drug must be protected from exposure to sunlight and stored for no more than 6 hours.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Berlition
According to reviews, Berlition 300 and Berlition 600 in any dosage form (tablets, injection solution) are often used to treat patients with diabetes mellitus and liver pathologies. At the same time, the drugs are considered very effective not only among patients, but also in medical circles. In 95% of cases, treatment with Berlition gives positive results, and there are practically no negative side effects. But it must be borne in mind that only a specialist should prescribe a drug and develop a therapy regimen.
Price for Berlition in pharmacies
The price of Berlition in tablets on average varies from 836 to 910 rubles (the package includes 30 pcs.). Berlition 300 in the form of a concentrate for the preparation of solution for infusion can be purchased for 606–658 rubles, and Berlition 600 in the same dosage form for 897–975 rubles.
Berlition: prices in online pharmacies
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Drug name Price Pharmacy |
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Berlition 300 25 mg / ml concentrate for preparation of solution for infusion 12 ml 5 pcs. 496 r Buy |
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Berlition 300 end for prig solution for inf. 25mg / ml 12ml 5 pcs. 561 r Buy |
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Berlition 300 300 mg film-coated tablets 30 pcs. 640 RUB Buy |
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Berlition 300 tablets p.o. 300mg 30 pcs. 702 RUB Buy |
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Berlition 600 25 mg / ml concentrate for preparation of solution for infusion 24 ml 5 pcs. 794 r Buy |
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Berlition 600 end for prig solution for inf. 25mg / ml 24ml 5 pcs. RUB 817 Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
