Thiocetam
Thiocetam: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Use in the elderly
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Tiocetam
ATX code: N06BX
Active ingredient: Piracetam + Thiotriazolin (Piracetam + Thiotriazoline)
Producer: JSC "Galichpharm" Ukraine
Description and photo update: 2018-22-10
Prices in pharmacies: from 499 rubles.
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Thiocetam is a nootropic drug.
Release form and composition
Dosage forms of release of Thiocetam:
- solution for intravenous and intramuscular administration: clear, colorless or slightly yellowish liquid (5 and 10 ml in colorless transparent glass ampoules, 10 ampoules in a box or 5 ampoules in blisters, 2 packages in a cardboard box. ampoules without a point or break ring, an ampoule scarifier is inserted into the box);
- film-coated tablets: round, biconvex, yellow, a white or almost white core can be seen in cross-section (10 pcs. in blisters, 3 or 6 packs in a cardboard box).
Composition of 1 ml solution for injection:
- active ingredients: piracetam - 100 mg, morpholinium-methyl-triazolyl-thioacetate (thiotriazoline) - 25 mg;
- additional component: water for injection - up to 1 ml.
Composition of 1 tablet:
- active substances: piracetam - 200 mg, morpholinium-methyl-triazolyl-thioacetate (thiotriazoline) - 50 mg;
- auxiliary components: calcium stearate, sucrose (powdered sugar), low molecular weight povidone (low molecular weight medical polyvinylpyrrolidone 12 600 ± 2700), potato starch, microcrystalline cellulose;
- film casing: opadry II yellow, including titanium dioxide, macrogol, lactose monohydrate, hypromellose, triacetin, aluminum varnish based on sunset yellow dye, aluminum varnish based on indigo carmine dye, aluminum varnish based on quinoline yellow dye, iron dye oxide yellow.
Pharmacological properties
Pharmacodynamics
Thiocetam is a cerebroactive agent that exhibits antioxidant, nootropic and anti-ischemic activity. The pharmacological properties of the drug are due to the mutual enhancement of the action of its active substances - piracetam and thiotriazoline.
Piracetam is a nootropic agent that is a cyclic derivative of gamma-aminobutyric acid (GABA), which acts directly on the brain, thereby improving consciousness, attention, memory and learning ability. It does not have a psychostimulating and sedative effect. At the neural level, the agent facilitates different types of synaptic transmission, with a predominant effect on the activity and density of postsynaptic receptors. Piracetam has a hemorheological effect, which is associated with its effect on the walls of blood vessels, erythrocytes and platelets. Thus, piracetam increases the indicators of short-term and long-term memory, eliminates amnesia, promotes the learning process, and improves cognitive and integrative brain activity.
Thiotriazoline is a drug that reacts with lipid radicals and reactive oxygen species due to the pronounced reducing properties of the thiol group, and also prevents the emergence of reactive oxygen species due to the reactivation of antiradical enzymes such as catalase, glutathione peroxidase and superoxide dismutase.
Pharmacokinetics
The pharmacokinetic parameters of Thiocetam have not been studied.
Indications for use
- chronic cerebral ischemia;
- diabetic encephalopathy;
- the recovery period of ischemic stroke (including cases of the presence of non-demented cognitive impairment).
Contraindications
- acute disturbance of cerebral circulation (hemorrhagic stroke);
- chorea of Huntington;
- psychomotor agitation at the time of prescribing the drug;
- severe chronic renal failure (creatinine clearance <20 ml / min);
- age up to 18 years;
- pregnancy and lactation;
- hypersensitivity to any active or auxiliary component of the drug.
In tablets, Thiocetam is also contraindicated in glucose-galactose malabsorption, fructose intolerance, hereditary lactose intolerance, sucrase / isomaltase or lactase deficiency.
The drug should be used with caution in the following cases:
- chronic renal failure (creatinine clearance 20–80 ml / min);
- hemostasis disorders, severe bleeding or surgery;
- old age (in the presence of cardiovascular pathologies).
Instructions for the use of Thiocetam: method and dosage
Injection
In the form of a solution, Thiocetam is administered intramuscularly or intravenously and only if there is no possibility of oral administration of the drug.
In diabetic encephalopathy, the recommended dose is 5 ml 1 time per day intramuscularly for 10 days with further transfer of the patient to the tablet form of the drug.
In other cases (chronic cerebrovascular accidents and the recovery period after ischemic stroke), depending on the clinical situation, intravenous infusion is prescribed once a day, 20-30 ml of solution diluted in 100-150 ml of 0.9% sodium chloride solution. The duration of therapy is 2 weeks, then the patient is transferred to Tiocetam tablets.
Film-coated tablets
Thiocetam tablets should be taken orally half an hour before meals. To avoid sleep disturbances, the last (evening) dose should be taken no later than 5 pm.
Recommended dosages:
- chronic disorders of cerebral circulation and the recovery period after ischemic stroke: 2 tab. 3 times a day for 25-30 days, if necessary, therapy is extended to 3-4 months;
- diabetic encephalopathy: 2 tab. 3 times a day for 45 days.
Side effects
- nervous system: tinnitus, drowsiness, insomnia, irritability, headache, imbalance, dizziness, confusion, anxiety, depression, mental agitation, hallucinations, asthenia, motor disinhibition, exacerbation of epilepsy, ataxia;
- gastrointestinal tract: abdominal pain (including gastralgia), dry mouth, diarrhea, bloating, nausea, vomiting;
- cardiovascular system: pain in the region of the heart, increased blood pressure, arrhythmia, tachycardia; in the elderly - exacerbation of coronary insufficiency;
- metabolism: weight gain;
- respiratory organs: attacks of suffocation, shortness of breath;
- organs of hearing: vertigo;
- allergic reactions: fever, urticaria, pruritus, dermatitis, angioedema, anaphylaxis, hypersensitivity reactions;
- local reactions with intravenous and intramuscular injection: pain at the injection site.
Overdose
In case of an overdose, the occurrence or increase in the severity of the existing dose-dependent side effects is possible. In this case, the drug is canceled and, if required, symptomatic therapy is carried out in order to eliminate the developed disorders.
special instructions
Elderly patients with long-term treatment show regular monitoring of renal function. Based on creatinine clearance, adjust the dose if necessary.
Influence on the ability to drive vehicles and complex mechanisms
According to the instructions, Thiocetam can cause side effects such as dizziness, confusion, drowsiness, imbalance, and motor disinhibition. In this regard, during treatment, it is worth refraining from activities that require increased concentration of attention and speed of reactions, including driving a car and working with complex mechanisms.
Application during pregnancy and lactation
During these periods, Thiocetam is not prescribed due to lack of experience with the drug.
Pediatric use
The drug is contraindicated in patients under 18 years of age due to lack of experience with its use.
With impaired renal function
Severe chronic renal failure with creatinine clearance (CC) <20 ml / min is a contraindication to the use of Tiocetam. If the CC is 20-80 ml / min, special care is required during the period of therapy.
Use in the elderly
Elderly people with concomitant pathologies of the cardiovascular system Thiocetam should be used with caution due to the high likelihood of side effects.
Drug interactions
Thiocetam should not be used in combination with products that have an acidic pH.
Piracetam enhances the effect of antianginal drugs and antidepressants.
Side effects such as sleep disturbances, irritability, and confusion can occur while taking thyroid hormones.
Concomitant use of alcohol does not affect the serum concentration of piracetam. The ethanol concentration also does not change if piracetam is used at a dose of up to 1600 mg.
The drug does not inhibit cytochrome P 450 isozymes. Interaction with other medicinal products is unlikely.
Analogs
Thiocetam analogs are: Glycine, Cavinton, Gopantam, Nootropil, Cerakson, Lucetam, Omaron, Encephabol, Cerebrolysin, Phezam, etc.
Terms and conditions of storage
Store out of the reach of children, protected from light, the solution - at a temperature of up to 25 ° С, tablets - at a temperature of 15–25 ° С.
The shelf life of the solution is 3 years, the tablets are 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews of Thiocetam
Patients who have undergone therapy with this nootropic drug leave various reviews about Thiocetam. The remedy has helped many a lot, so they consider it one of the most effective. However, some people note the ineffectiveness of the treatment or complain about the side effects that have arisen. Thus, we can conclude that Thiocetam is an effective drug, but it should be prescribed individually and in a timely manner, and therapy should be carried out carefully, under close medical supervision.
The price of Thiocetam in pharmacies
The price of Thiocetam tablets is 500-570 rubles per pack of 60 tablets. The cost of the solution for injection is 410-615 rubles for 10 ampoules of 5 ml.
Thiocetam: prices in online pharmacies
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Drug name Price Pharmacy |
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Thiocetam 25 mg + 100 mg solution for intravenous and intramuscular administration 5 ml 10 pcs. RUB 499 Buy |
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Thiocetam 50 mg + 200 mg film-coated tablets 60 pcs. 505 RUB Buy |
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Thiocetam tablets p.o. 50mg + 200mg 60 pcs. RUB 520 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
