Pentamin
Pentamin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. In case of impaired renal function
- 11. For violations of liver function
- 12. Use in the elderly
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews of the drug
- 18. The price of the drug in pharmacies
Latin name: Pentamin
ATX code: C02BC
Active ingredient: azamethonium bromide (azamethonium bromide)
Producer: Dalkhimfarm, JSC (Russia)
Description and photo update: 02.10.2019
Prices in pharmacies: from 1150 rubles.
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Pentamin is a ganglion blocker, has a hypotensive, veno- and arteriodilating effect.
Release form and composition
Dosage form - solution for intramuscular (i / m) and intravenous (i / v) administration 5%: colorless transparent liquid (1 ml or 2 ml in glass neutral ampoules, 10 ampoules in a cardboard box or in a blister strip of 5 ampoules, in a cardboard box 2 packs).
The active ingredient of Pentamine is azamethonium bromide, in 1 ml - 50 mg.
Auxiliary components: water for injection.
Pharmacological properties
Pharmacodynamics
The active component of the drug Pentamine is azamethonium bromide, by blocking the n-cholinergic receptors of the sympathetic and parasympathetic autonomic ganglia, depressing the chromaffin tissue of the adrenal glands and carotid glomeruli. In high doses, the substance can block n-cholinergic receptors of the central nervous system and skeletal muscle tissue. Pentamin has hypotensive, arterio- and venodilatory efficacy.
Azamethonium bromide reduces the excretion of catecholamines by the adrenal glands and helps to weaken reflex pressor reactions, which may result in tachycardia, mydriasis, paresis of accommodation, expansion of the bronchi, weakening of the motility of the gastrointestinal tract and the tone of the bladder, inhibition of glandular secretion.
Indications for use
- Hypertensive crisis;
- Spasms of the intestines, biliary tract, peripheral vessels;
- Cerebral edema;
- Renal colic;
- Acute attacks of bronchial asthma (for relief);
- Causalgia;
- Eclampsia;
- Pulmonary edema.
According to the instructions, Pentamin is also used in anesthesiology - to create controlled hypotension, in urology - to facilitate cystoscopic examinations in men.
Contraindications
- Myocardial infarction;
- Arterial hypotension;
- Thrombophlebitis;
- Closed-angle glaucoma;
- Degenerative changes in the central nervous system;
- Hepatic and / or renal failure.
Instructions for the use of Pentamin: method and dosage
Pentamin solution is intended for intramuscular and intravenous administration.
Recommended dosage:
- Vascular spasms and other pathologies that do not require emergency measures: i / m - 50 mg 2-3 times a day, if necessary, a single dose is increased to 75-100 mg. The maximum single dose is 150 mg, the daily dose is 450 mg of the drug;
- Cerebral edema, hypertensive crisis, pulmonary edema: i / m - up to 100 mg or slowly i / v (under the control of blood pressure (BP)) - 10-25 mg (0.2-0.5 ml solution), diluted in 20 ml of 5% glucose solution or isotonic sodium chloride solution;
- Controlled arterial hypotension: before the operation, 40-60 mg is injected intravenously, if necessary, an increase in the dose to 120-180 mg is indicated.
Side effects
- Digestive system: dry mouth;
- Nervous system: weakness, dizziness;
- Cardiovascular system: tachycardia, orthostatic hypotension;
- Organ of vision: mydriasis.
Overdose
Symptoms of an overdose of Pentamin are a drop in blood pressure, paralytic intestinal obstruction, a violation of the mechanism of neuromuscular transmission, atonic anuria.
When treating the condition, it is recommended first of all to give the patient a horizontal position, raising the lower limbs above the level of the pelvis. For drug treatment, anticholinesterase drugs, alpha-adrenomimetics (with severe hypotension) and m-cholinomimetics are used. If necessary, oxygen therapy and artificial ventilation are performed.
special instructions
After the introduction of Pentamin, the patient needs to be in the supine position for 1-2 hours, otherwise the risk of orthostatic hypotension increases.
Influence on the ability to drive vehicles and complex mechanisms
During therapy with Pentamine, it is contraindicated to drive vehicles, as well as engage in other potentially hazardous activities that require the speed of psychomotor reactions, high concentration of attention and accuracy of movements.
Application during pregnancy and lactation
There is no data on the safety of azamethonium bromide during pregnancy and during breastfeeding.
With impaired renal function
The use of Pentamin is contraindicated in patients with renal insufficiency.
For violations of liver function
The use of Pentamin is contraindicated in patients with hepatic insufficiency.
Use in the elderly
Care should be taken when prescribing Pentamin to elderly patients.
Drug interactions
With the simultaneous use of Pentamin:
- Tricyclic antidepressants, ephedrine, mezaton reduce the hypotensive effect of azamethonium bromide;
- Antihypertensive drugs, including non-depolarizing muscle relaxants, increase the effect of the drug.
Analogs
Analogs of Pentamin are: Pendiomide, Pentametazene, Azamethonium bromide.
Terms and conditions of storage
Keep out of the reach of children.
Store in a dark place at temperatures up to 18-20 ° C.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about the drug
Since the drug is used mainly for treatment in a hospital under medical supervision, which ensures that the solution is used only according to indications and strictly in prescribed doses, there are few reviews about Pentamine, almost all of them are positive.
The price of the drug in pharmacies
The approximate price of Pentamin (solution for intravenous and intramuscular administration of 50 mg / ml) for 10 ampoules in a package can range from 1780 to 2040 rubles.
Pentamin: prices in online pharmacies
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Drug name Price Pharmacy |
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Pentamin 50 mg / ml solution for intravenous and intramuscular administration 1 ml 10 pcs. 1150 RUB Buy |
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Pentamine solution for in. 5% amp. 1ml 10 pcs. 1396 RUB Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
