Mikozhinaks
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Mikozhinaks is a complex drug intended for topical use in gynecology.
Release form and composition
Mikozhinaks is produced in the form of vaginal tablets (12 pcs. In strips of aluminum foil, in a cardboard box 1 strip).
The composition of 1 tablet includes:
- Nystatin - 100 thousand IU (international units);
- Metronidazole - 200 mg;
- Chloramphenicol - 80 mg;
- Dexamethasone acetate - 0.5 mg;
- Excipients, including lactose monohydrate.
Indications for use
Mikozhinax is used to treat infectious gynecological diseases caused by microorganisms sensitive to its active substances:
- Trichomonas vaginitis;
- Candidal vaginitis;
- Bacterial vaginitis;
- Mixed vaginitis caused by yeast-like fungi, anaerobic bacteria, Trichomonas.
In addition, the drug is prescribed during the preparation of patients for gynecological surgical interventions.
Contraindications
Absolute:
- Childhood;
- Pregnancy;
- Lactation;
- Individual intolerance to the components of Mikozhinax or other drugs of the imidazole group.
Relative:
- Severe neurological diseases (both acute and chronic);
- Progressive or chronic neuropathy.
Method of administration and dosage
Mikozhinax is intended for intravaginal use. The tablet should be injected as deep as possible into the vagina, after moistening with water. For at least 15-30 minutes after the procedure, you must remain in the supine position.
Usually, 1 tablet is prescribed once a day, preferably at night. The duration of treatment in each case is determined by the doctor. The recommended course is 10 days. Depending on the severity of the disease, oral forms of metronidazole may additionally be prescribed.
In the case of preparation for surgery, Mikozhinax is used 5 days before and 5 days after surgery.
Side effects
Mikozhinax can cause local reactions such as irritation and itching of the vaginal mucosa, burning sensation, and pain in the vagina.
Given the possibility of systemic absorption of the active substances of the drug, the likelihood of developing systemic side effects cannot be excluded:
- Gastrointestinal tract and hepatobiliary system: pain in the epigastric or abdominal region, diarrhea, stool disturbance, vomiting, loss of appetite, change in taste, inflammation of the oral cavity; in isolated cases - pancreatitis, hepatitis with symptoms of cholestasis, liver dysfunction;
- Central and peripheral nervous system: peripheral sensory neuropathy, headache, encephalopathy, dizziness, hallucinations, convulsions, psychotic disorders, subacute brain syndrome (nystagmus, tremor, ataxia, dysarthria, gait disturbances);
- Blood system: thrombocytopenia, agranulocytosis, neutropenia, leukopenia;
- Allergic reactions: pustular rash, pruritus, urticaria, Quincke's edema, hyperemia of the skin, anaphylactic shock;
- Others: diplopia, decreased visual acuity, red-brown urine staining, false positive Nelson test results.
special instructions
Menstruation is not a reason to discontinue the drug.
During the treatment, it is recommended to use an intimate hygiene product with an alkaline or neutral pH, and also wear cotton underwear. It is forbidden to carry out vaginal douching, use hygienic tampons, and have sexual intercourse.
When treating vaginitis caused by Trichomonas vaginalis, treatment (along with oral administration of metronidazole) should be carried out simultaneously by both sexual partners.
During treatment, it is recommended to refrain from driving vehicles and working with potentially dangerous machinery.
Drug interactions
In the case of the simultaneous appointment of Mikozhinax with the oral form of metronidazole, the peripheral blood picture should be monitored.
Metronidazole is contraindicated in combination with disulfiram (due to the risk of psychotic reactions).
During the treatment period, it is forbidden to drink alcohol and take medications that include ethyl alcohol, because there is a high probability of developing a disulfiram-like reaction. Drinking alcohol is allowed no earlier than 24 hours after the last vaginal tablet is inserted.
If necessary, the simultaneous use of cyclosporine or creatinine, it is necessary to control their concentration in blood plasma.
Patients receiving oral anticoagulants at the same time should monitor prothrombin time and, if necessary, adjust their dose.
Metronidazole can increase the toxicity of lithium and fluorouracil preparations, increase plasma concentrations of cyclosporine and busulfan, and reduce the strength of latex contraceptives (including diaphragms and condoms).
Plasma concentration of metronidazole can be reduced by phenytoin and phenobarbital.
Analogs
Analogues of Mikozhinaks are: Vagilak, Epigen, Metrogyl, Vagid, Gineconorm, Ginekit, Vagiklin.
Terms and conditions of storage
Store at temperatures up to 25˚С.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
