Pyridoxine

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Pyridoxine: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. For violations of liver function
12. Drug interactions
13. Analogs
14. Terms and conditions of storage
15. Terms of dispensing from pharmacies
16. Reviews
17. Price in pharmacies

Latin name: Pyridoxine

ATX code: A11HA02

Active ingredient: pyridoxine (pyridoxine)

Manufacturer: Yerevan Chemical-Pharmaceutical Firm (Armenia), Moskhimpharmpreparaty named after ON. Semashko, JSC (Russia), Borisov Plant of Medical Products (Republic of Belarus), Pharmstandard-Ufa Vitamin Plant (Russia), Ozon Pharm (Russia), Lvovdialek DP GAK Ukrmedprom (Ukraine), Veropharm (Russia)

Description and photo update: 2019-21-08

Prices in pharmacies: from 25 rubles.

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Pyridoxine is a drug that helps to replenish the lack of vitamin B6.

Release form and composition

Dosage forms of release:

Tablets (in contoured or non-cell packs of 10 pcs., 1-5 packs in a cardboard box; in dark glass or polymer cans, 50 pcs., 1 can in a cardboard box);
Solution for injection (in 1 ml ampoules, 5 or 10 pcs. In blisters, 1 or 2 packages in a cardboard box or 10 pcs. In a cardboard box).

The active substance is pyridoxine (in the form of hydrochloride):

1 tablet - 10 mg;
1 ml solution for injection - 10 or 50 mg.

Pharmacological properties

Pharmacodynamics

Pyridoxine is a vitamin B ₆. Entering the body, pyridoxine is phosphorylated and converted into pyridoxal-5-phosphate. It is included in the composition of enzymes that carry out transamination, racemization and decarboxylation of amino acids, as well as enzymatic conversion of hydroxylated and sulfur-containing amino acids.

Pyridoxine is essential for the normal functioning of the central and peripheral nervous system. Participates in the metabolism of cysteine, methionine, tryptophan, glutamic and other amino acids. Promotes the normalization of lipid metabolism. Plays an important role in the exchange of histamine.

Isolated deficiency of vitamin B ₆ is very rare, mainly in children who eat a special artificial diet. Lack of pyridoxine is manifested by diarrhea, anemia, seizures, in some cases leads to the development of peripheral neuropathy.

The daily requirement for vitamin B ₆: adults - 2-2.5 mg, boys 14-17 years old - 2.2 mg, girls 14-17 years old - 1.9 mg, teenagers 11-13 years old - 2 mg, children aged 7-10 years - 1.7 mg, 5-6 years - 1.4 mg, 3-4 years - 1.3 mg, 1.5-2 years - 1 mg, from 1 to 1.5 years - 0, 9 mg, from 6 months to 1 year - 0.5 mg. Women are advised to receive 2 mg / day, additionally during pregnancy - 0.3 mg, while breastfeeding - 0.5 mg.

Pharmacokinetics

Pyridoxine is metabolized in the liver, resulting in the formation of pharmacologically active metabolites pyridoxamine phosphate and pyridoxal phosphate.

It is characterized by a high bond with plasma proteins - 90%. It is well absorbed throughout the entire small intestine, absorbed in large quantities and penetrates into all tissues. It is distributed mainly in the liver, to a lesser extent in the central nervous system and muscles. Penetrates through the placenta and into breast milk.

It is excreted by the kidneys (when administered intravenously, 2% is excreted in the bile). The half-life is 15–20 days. It is excreted during hemodialysis.

Indications for use

According to the instructions, Pyridoxine is used for the prevention and treatment of hypo- and vitamin deficiency B ₆.

As part of complex therapy, the drug is prescribed for the following diseases:

diseases of the nervous system: seasickness and air sickness, paralysis of central or peripheral origin, neuritis, neuralgia, sciatica, Little's disease, parkinsonism, Meniere's disease and syndrome;
dermatological diseases: neurodermatitis, psoriasis, shingles, dermatitis (including seborrheic), exudative diathesis, etc.;
acute and chronic hepatitis, alcoholism;
toxicosis of pregnant women: anemia (microcytic, hypochromic, sideroblastic);
congenital pyridoxine-dependent convulsive syndrome of newborns.

Pyridoxine is also prescribed to increase urine output and enhance the action of diuretics, prevent and treat the neurotoxicity of isoniazid or other anti-tuberculosis drugs.

Contraindications

Pyridoxine tablets and solution in ampoules are contraindicated in the presence of hypersensitivity to the components of the drug.

In patients with gastric ulcer and duodenal ulcer and ischemic heart disease, caution should be exercised when prescribing the drug.

Instructions for the use of Pyridoxine: method and dosage

The recommended dosage regimen for adults with vitamin B6 deficiency:

Tablets: single dose - 80 mg, frequency of administration - 4 times a day;
Solution for injection (subcutaneously, intravenously or intramuscularly): daily dose - 50-150 mg.

The duration of the course is determined by the doctor on an individual basis.

For prevention, the drug is prescribed in a daily dose of 40 mg.

Side effects

In some cases, during the period of use of the drug, disorders in the form of allergic reactions and hypersecretion of hydrochloric acid may develop.

Overdose

No information available.

special instructions

When high doses of Pyridoxine are prescribed in patients with severe liver damage, deterioration of its function may be observed.

Influence on the ability to drive vehicles and complex mechanisms

There are no reports of adverse effects of vitamin B ₆ on reaction speed and concentration.

Application during pregnancy and lactation

Pyridoxine can be used during pregnancy and lactation as directed by a doctor.

Pediatric use

There are no age restrictions for the use of the drug. Pyridoxine is approved for use from birth.

For the treatment of pyridoxine-dependent convulsive syndrome in newborns, Pyridoxine in ampoules is administered intravenously or intramuscularly at a dose of 100 mg. For other indications, children are prescribed 20 mg of pyridoxine (0.5 ml of a 5% solution) per day for 2 weeks.

Pyridoxine tablets are prescribed for prophylactic and therapeutic purposes in accordance with the recommendations according to age.

For violations of liver function

The drug should be used with caution in severe liver damage, since vitamin B ₆ in high doses can cause deterioration of its function.

Drug interactions

With the simultaneous use of certain substances / drugs, the following effects may develop:

Diuretics: their action is potentiated;
Penicillamine, isonicotinhydrazide, cycloserine: the effectiveness of pyridoxine hydrochloride decreases;
Levodopa: its effects are reduced or completely inhibited;
Phenytoin, phenobarbital: their concentration in blood plasma decreases;
Hormonal contraceptives: the concentration of pyridoxine hydrochloride in blood plasma increases.

Analogs

Pyridoxine analogs are: Pyridoxine hydrochloride, Pyridoxine bufus, Pyridoxine-Vial.

Terms and conditions of storage

Store in a dry, dark place, out of reach of children, at a temperature not exceeding 25 ° C.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Pyridoxine

On forums and specialized medical sites, there are mostly positive reviews about Pyridoxine. This vitamin is very often used in the complex therapy of various diseases, and patients note that it significantly improves the therapeutic effect.

Many patients take a course on their own to increase immunity, strengthen the nervous system, strengthen hair and nails. They pay attention to a good result, despite the low cost of the drug: stamina and mood increase, hair and nail growth accelerates, hair and skin condition improves, and nails become stronger.

Among the large number of positive reviews, occasionally there are negative messages that contain complaints about the development of side effects when taking Pyridoxine tablets, such as increased acidity of gastric contents and pain and abdominal pain. Experts in this case emphasize: the instructions for the drug indicate that it can cause hypersecretion of hydrochloric acid, and this should be taken into account in patients with gastric ulcer and duodenal ulcer. In rare cases, the drug causes allergic reactions, but they usually go away on their own after you stop taking the pills.

The price of Pyridoxine in pharmacies

Approximate prices of Pyridoxine: 50 tablets of 10 mg - 35-66 rubles, 10 ampoules of 5% solution of 1 ml - 23-36 rubles.