Tsifran

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Instructions for use:

1. Pharmacological action
2. Release form
3. Indications for use
4. Contraindications
5. Instructions for use
6. Side effects
7. Analogs of the drug
8. Storage conditions

Prices in online pharmacies:

from 25 rubles.

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Tsifran is an antibacterial drug of the quinolone / fluoroquinolone group.

Pharmacological action of Tsifran

Tsifran belongs to broad-spectrum antimicrobial drugs, the main active ingredient of which is ciprofloxacin. The therapeutic effect of the drug is based on the mechanism of inhibiting the enzyme of bacteria and disrupting the synthesis of their DNA. In addition, Tsifran is able to increase the permeability of the cell membrane of harmful microorganisms (in particular, bacteria) and have a bactericidal effect on them. The action of the drug affects both bacteria in the reproduction phase and those at rest.

Tsifran is active against a number of aerobic gram-negative bacteria, including Enterobacter spp, Escherichia coli, Citrobacter spp, Shigella Spp, Morganella morganii, Moraxella spp, Salmonella spp and others. Also noted the activity of Tsifran against aerobic gram-positive bacteria: Listeria monocytogenes, Staphylococcus aureus, Streptococcus pneumoniae and a number of others, including strains that produce penicillinase. Finally, the drug is active against intracellular bacteria: Brucella spp, Chlamydia trachomatis, Legionella spp, Mycoplasma hominis.

However, the instruction to Tsifran notes the resistance of anaerobic bacteria to the drug.

The post-antibiotic effect after taking the drug lasts up to 6 hours, which prevents further bacterial growth.

In addition, treatment with Cifran does not disturb the natural microflora of the vagina and intestines.

Release form

Three forms of the drug are available in pharmacy chains:

Tablets with a mass fraction of ciprofloxacin 250 or 500 mg. The tablets are coated and packed in a cardboard box in the amount of 10 or 100 pieces;
Solution for infusion containing 2 mg of ciprofloxacin in 1 ml of Tsifran. The content of the drug in one bottle is 100 ml. The bottle is in a box;
Eye drops. 1 ml of drops contains 3 mg of ciprofloxacin. Drops are packed in a dark glass bottle, placed in a cardboard box.

Indications for Tsifran's use

Indications for Tsifran are infectious and inflammatory diseases caused by microorganisms that are sensitive to the action of the drug. According to the instructions for Tsifran, the drug is effective for the following diseases:

with infections of the genitourinary system (including chronic and acute pyelonephritis, cystitis, prostatitis, epididymitis);
with respiratory tract infections, which include bronchopneumonia, pneumonia, exacerbation of chronic bronchitis, acute bronchitis, pleurisy, empyema, infected bronchiectasis, lung abscesses;
with gonorrhea, urethritis, proctitis, pharyngitis, including forms caused by resistant gonococci;
with infections of ENT organs, including otitis media and external otitis media, mastoiditis, sinusitis;
with infections of soft tissues and skin, among them - wounds and burns, infected ulcers, cellulitis, abscesses;
with gastrointestinal infections, including peritonitis, cholangitis, typhoid fever, intra-abdominal abscesses, empyema of the gallbladder;
with infectious and inflammatory diseases of the pelvic organs, including endometritis and salpingitis;
for infections of joints and bones, including chronic and acute osteomyelitis, septic arthritis;
with septicemia, bacteremia, infections in patients with a weakened immune system.

The instruction to Tsifran describes the effectiveness of intravenous administration of the drug in the prevention of postoperative infections.

Contraindications

Treatment with Cifran is not recommended in case of hypersensitivity to quinols, in particular to ciprofloxacin. Also contraindications are pregnancy and lactation, age up to 12 years.

The use of Tsifran by some groups of patients is permissible only subject to careful medical supervision during treatment, these include:

patients with severe cerebral atherosclerosis;
patients with disorders of cerebral circulation;
patients with diagnosed mental illness;
patients with epileptic syndrome and epilepsy;
patients with severe hepatic and / or renal impairment;
elderly patients.

Instructions for use of Tsifran

The dosage for the treatment with Tsifran is set strictly individually, based on the severity of the disease, the type of pathogen, body weight, patient's age and kidney function.

For children after 12 years of age, Tsifran is indicated in an amount of 5-10 mg / kg of body weight per day. In this case, the dosage is divided into two doses. The tablets are preferably taken before meals.

Cifran in the form of intravenous infusions for adults is administered in an amount of 200 mg twice a day for infections of the lower extremities and urinary tract. The drug is administered slowly. For other infections, Tsifran should be administered at the same rate in an amount of 200 mg every 12 hours.

With septicemia and bacteremia, up to 400 mg of the drug is administered every 12 hours.

In the case of severe renal impairment, the daily dose is reduced by 2 times.

The duration of i / v use of Tsifran weighing 200 mg is 60 minutes.

In some cases, after a course of intravenous administration of Tsifran, you should switch to oral administration of the drug.

The duration of treatment with Tsifran and drug analogues is determined by the doctor based on the patient's individual indicators. It is recommended to carry out treatment for at least 5-7 days in acute infectious diseases, after the disappearance of the clinical symptoms of infection, the course of treatment is extended for another 3 days.

Eye drops are recommended to be instilled in 1-2 drops into the lower conjunctival sac of the diseased eye every 4 hours in case of mild and moderate diseases. severity. In the case of a severe course of the disease, the indications for Tsifran are as follows: every hour, 2 drops until the moment when there is improvement. After that, the dose of the drug is reduced.

Side effects of Tsifran

The use of Tsifran and analogs of the drug in rare cases can cause a number of undesirable reactions. Their list must be familiarized with before the start of admission:

abdominal pain, flatulence, vomiting, nausea, hepatitis;
paresthesia, headache, irritability, dizziness, confusion, migraine, fainting, depression, tremor of the limbs;
impairment of smell, sight and taste, hearing loss;
heart rhythm disturbances, tachycardia;
leukopenia, eosinophilia, anemia, leukocytosis, hemolytic anemia, thrombocytosis;
hypoprothrombinemia, hyperglycemia, increased activity of hepatic transaminases;
hematuria, glomerulonephritis, polyuria, dysuria, urinary retention, urethral bleeding;
arthralgia, myalgia, tendovaginitis, arthritis, tendon ruptures;
general weakness, photosensitivity, superinfection (in the form of candidiasis, pseudomembranous colitis).

Drug analogues

To drugs similar in the mode of action and composition of Tsifran include:

Basigen;
Afenoxin;
Alcipro;
Ifypro;
Quintor;
Quipro;
Oftocypro, etc.

Storage conditions

It is recommended to store Tsifran in a dry place at temperatures up to 25 ° C, away from sunlight. The shelf life is 2 years.

Tsifran: prices in online pharmacies

Drug name

Price

Pharmacy

Cifran 250 mg film-coated tablets 10 pcs.

RUB 25

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Cifran 500 mg film-coated tablets 10 pcs.

73 rbl.

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Tsifran OD 500 mg film-coated tablets of prolonged action 10 pcs.

170 RUB

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Tsifran OD 1000 mg film-coated tablets of prolonged action 10 pcs.

188 r

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Tsifran OD tablets p.o. prolonged action 500mg 10 pcs.

204 RUB

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Cifran ST 500 mg + 600 mg film-coated tablets 10 pcs.

294 r

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Reviews Tsifran ST

294 r

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Cifran ST tablets p.o. 500 / 600mg 10 pcs.

308 RUB

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Tsifran OD tablets p.o. prolonged action 1000mg 10 pcs.

309 RUB

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Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!