Panatus forte
Panatus forte: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Panatus Forte
ATX code: R05DB13
Active ingredient: butamirate (Butamirate)
Manufacturer: JSC "Krka, dd, Novo mesto" (Slovenia)
Description and photo updated: 2018-29-11
Prices in pharmacies: from 174 rubles.
Buy
Panatus forte is a centrally acting antitussive agent.
Release form and composition
- syrup: a clear liquid from colorless to light yellow, with a characteristic lemon odor (200 ml in dark glass bottles with first opening control, 1 bottle and a measuring spoon in a cardboard box);
- film-coated tablets: round, biconvex, chamfered, red-brown; on the break, a rough white mass is visible, covered with a red-brown shell (10 pcs. in blisters, 1 blister in a cardboard box).
Each pack also contains instructions for using Panatus forte.
Composition of 5 ml syrup:
- active substance: butamirate citrate - 7.5 mg;
- auxiliary components: liquid sorbitol, purified water, glycerol, sodium hydroxide, sodium benzoate, sodium saccharin, citric acid monohydrate, lemon flavor.
Composition of 1 film-coated tablet:
- active substance: butamirate citrate - 50 mg;
- auxiliary components: colloidal silicon dioxide, hypromellose K15M Premium, povidone K-25, magnesium stearate, talc, lactose monohydrate;
- film shell: propylene glycol, hypromellose 6 mPas, talc, titanium dioxide (E171), iron dye red oxide (E172).
Pharmacological properties
Pharmacodynamics
The active ingredient of Panatusa forte is butamirate, a centrally acting antitussive agent that does not belong to opium alkaloids either in terms of chemical or pharmacological characteristics.
Has a direct effect on the cough center, thereby suppressing coughing. Possesses bronchodilatory activity. Improves spirometry (reduces airway resistance) and blood oxygenation, making breathing easier.
Pharmacokinetics
Once in the gastrointestinal tract, butamirate is rapidly and completely absorbed.
With repeated use, the plasma concentration of the drug remains linear, cumulation in the body is not observed.
Butamirate undergoes hydrolysis in the blood, initially to metabolites of 2-phenylbutyric acid and diethylaminoethoxyethanol, which also have antitussive activity.
The substance itself and its metabolites are almost completely (about 95%) bound to plasma proteins. This explains their long-term therapeutic effect and long T ½ (half-life).
Metabolites are excreted primarily by the kidneys, with acidic metabolites being significantly associated with glucuronic acid. T ½ is 6 hours.
Indications for use
- treatment of dry cough of any etiology, including whooping cough;
- suppression of cough during surgery, bronchoscopy, in the preoperative and postoperative periods.
Contraindications
Absolute:
- fructose intolerance - for syrup;
- lack of lactase, lactose intolerance and glucose-galactose malabsorption syndrome - for tablets;
- children under 3 years old - for syrup, up to 12 years old - for tablets;
- I trimester of pregnancy and lactation;
- hypersensitivity to any component of the drug.
Panatus forte is used with caution in the II and III trimesters of pregnancy.
Panatus forte, instructions for use: method and dosage
The drug should be taken orally, before meals.
Depending on the age, Panatus forte syrup is prescribed in the following doses:
- 3-6 years old - 5 ml 3 times a day;
- 6-12 years - 10 ml 3 times a day;
- 12-18 years old - 15 ml 3 times a day;
- over 18 years old - 15 ml 4 times a day.
1 scoop = 5 ml syrup.
Depending on the age, Panatus forte tablets are prescribed in the following doses:
- 12-18 years old - 1 pc. 1-2 times a day;
- over 18 years old - 1 pc. 2-3 times a day.
The duration of treatment is up to 7 days. If the cough persists, a doctor should be consulted.
Side effects
Panatus forte is generally well tolerated.
In rare cases (from ≥ 1/10 000 to <1/1000), the following adverse reactions occur:
- on the part of the skin: exanthema;
- from the central nervous system: drowsiness, dizziness;
- from the gastrointestinal tract: nausea, diarrhea, vomiting;
- others: allergic reactions.
Overdose
In case of an overdose, butamirate causes the following reactions: abdominal pain, nausea, diarrhea, vomiting, decreased blood pressure, dizziness, impaired coordination of movements, irritability, drowsiness.
In case of taking an excessive dose of the drug, you should rinse the stomach, take an adsorbent (for example, activated carbon) and a laxative. Further treatment is symptomatic, including maintaining the functions of the respiratory and cardiovascular systems. The antidote is unknown.
special instructions
Panatus forte syrup can be prescribed for diabetes mellitus, since it contains sodium saccharin and sorbitol as sweeteners. The content of sorbitol in a single dose, depending on its volume: in 1 measuring spoon (5 ml) - 1.75 g, in 2 measuring spoons (10 ml) - 3.5 g, in 3 measuring spoons (15 ml) - 5, 25 g
The composition of 1 tablet Panatus forte contains 0.285 g of lactose.
Influence on the ability to drive vehicles and complex mechanisms
The drug can cause drowsiness and dizziness, which should be taken into account by vehicle drivers and persons performing potentially hazardous types of work that require speed of reactions and increased attention.
Application during pregnancy and lactation
Whether butamirate penetrates the placental barrier is unknown. There is no information on the safety of using the drug during pregnancy. In this regard, it is not recommended to take Panatus forte in the first trimester, in the II and III trimesters, the use is possible only as directed by the attending physician.
There are no data on the excretion of butamirate in breast milk, so the drug is not recommended for women who are breastfeeding.
Pediatric use
Age restrictions:
- syrup - up to 3 years;
- tablets - up to 12 years.
Drug interactions
Panatus forte is not recommended to be used simultaneously with ethanol and drugs that have a depressing effect on the central nervous system, including hypnotics, neuroleptics and tranquilizers.
You should not take expectorant drugs during treatment, otherwise sputum may accumulate in the respiratory tract.
Other drug interactions of butamirate have not been described.
Analogs
The analogues of Panatus forte are: Sinekod, Panatus, Omnitus, Codelac Neo.
Terms and conditions of storage
Store in its original packaging at a temperature not exceeding 25 ° C out of the reach of children.
The shelf life of the syrup is 4 years, of the tablets - 5 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Panatus Fort
Patients leave mostly positive reviews about Panatus forte, noting its high efficiency when used according to indications, good tolerance and relatively low cost.
In rare reports of a negative nature, there are complaints about the lack of effect after the course of treatment.
Price for Panatus forte in pharmacies
Depending on the place of sale, prices for Panatus Fort can be:
- syrup 7.5 mg / 5 ml (bottle 200 ml) - 195-248 rubles;
- film-coated tablets, 50 mg (10 pcs. in a package) - 188-240 rubles.
Panatus forte: prices in online pharmacies
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Drug name Price Pharmacy |
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Panatus Forte 50 mg film-coated tablets 10 pcs. 174 r Buy |
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Panatus Forte 7.5 mg / 5 ml syrup 200 ml 1 pc. 175 RUB Buy |
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Panatus Forte tablets p.o. 50mg 10 pcs. 206 r Buy |
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Panatus Forte syrup 7,5mg / 5ml fl. 200ml 216 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
