Codelac Neo - Instruction, Application For Children, Syrup, Tablets, Drops

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Codelac Neo

Codelac Neo: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Codelac Neo

ATX code: R05DB13

Active ingredient: Butamirat (Butamiratum)

Manufacturer: Pharmstandard-UfaVITA, Pharmstandard-Leksredstva

Description and photo update: 2018-22-10

Prices in pharmacies: from 150 rubles.

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Codelac Neo is a centrally acting non-opioid antitussive drug.

Release form and composition

• coated tablets with modified release: round, biconvex, white (10 pcs. in blisters, 30 and 50 pcs. in polymer cans; in a cardboard box 1 can or 1-2 blisters);
• syrup: colorless liquid (100 and 200 ml in dark glass vials, 1 vial in a cardboard box);
• drops for oral administration: transparent or with a slight opalescence, from colorless to colorless with a yellowish tinge liquid with a vanilla smell (20 ml each in dark glass dropper bottles, 1 bottle in a cardboard box).

Composition of 1 tablet:

• active substance: butamirate citrate - 50 mg (in terms of 100% substance);
• additional components: magnesium stearate, hypromellose (methocel K4M), low molecular weight povidone (low molecular weight polyvinylpyrrolidone), talc, lactose monohydrate (milk sugar), colloidal silicon dioxide (aerosil);
• film casing: Opadry II white 57М280000, including maltodextrin / dextrin, titanium dioxide, hypromellose (15 cP), polydextrose, talc, glycerin / glycerol.

Composition of 5 ml syrup:

• active substance: butamirate citrate - 7.5 mg;
• auxiliary components: sodium saccharinate, sodium hydroxide solution 30%, glycerol (glycerin), purified water, benzoic acid, ethanol (ethyl alcohol) 95%, vanillin, sorbitol (Neosorb 70/70, sorbitol syrup).

Composition of 1 ml drops:

• active substance: butamirate citrate - 5 mg;
• auxiliary components: sodium saccharinate, sodium hydroxide solution 30%, glycerol (glycerin), purified water, benzoic acid, ethanol (ethyl alcohol) 95%, vanillin, sorbitol (Neosorb 70/70, sorbitol syrup).

Pharmacological properties

Pharmacodynamics

Butamirate citrate is neither pharmacologically nor chemically related to the opium alkaloids.

It has a direct effect on the cough center, has a moderate bronchodilatory, expectorant and anti-inflammatory effect. Improves blood oxygenation, reduces airway resistance, thereby improving spirometry performance.

Pharmacokinetics

After taking drops or syrup of Codelac Neo Butamirate, citrate is completely and quickly absorbed from the gastrointestinal tract. In the case of taking a dose of 150 mg, the maximum concentration of the main metabolite - 2-phenylbutyric acid - in the blood plasma is 6.4 μg / ml, and is reached after about 90 minutes.

In tablet form, Codelac Neo is also highly absorbed. After oral administration, the maximum concentration of 2-phenylbutyric acid in the blood plasma is 1.4 μg / ml, and is reached within 9 hours.

The hydrolysis of the active substance of Codelac Neo begins in the blood, initially two metabolites are formed - 2-phenylbutyric acid and diethylaminoethoxyethanol, which also have antitussive properties and, like butamirate, are characterized by a high bond with plasma proteins (about 95%), which is why they have a long half-life.

2-phenylbutyric acid is partially metabolized by hydroxylation.

The drug does not have a cumulative effect upon repeated administration.

Metabolites are excreted mainly by the kidneys in the urine, while 2-phenylbutyric acid is excreted mainly in the form associated with glucuronic acid.

The half-life after taking syrup / drops is 6 hours, tablets - 13 hours.

Indications for use

Codelac Neo is intended for the treatment of dry coughs of any etiology, including whooping cough, colds and flu.

Also, the drug is used during bronchoscopy and surgical interventions, in the preoperative and postoperative periods.

Contraindications

• I trimester of pregnancy;
• period of breastfeeding;
• hypersensitivity to drug components.

Additional contraindications for different forms of release of Codelac Neo:

• tablets: glucose-galactose malabsorption, lactase deficiency, lactose intolerance, age up to 18 years;
• syrup: fructose intolerance, children under 3 years of age;
• drops: fructose intolerance, children up to 2 months.

In the following conditions / diseases, the drug should be used with caution due to the risk of complications:

• liver disease;
• alcoholism;
• diseases of the brain;
• epilepsy;
• a tendency to drug dependence.

Instructions for use of Codelac Neo: method and dosage

All dosage forms of Codelac Neo are indicated for oral administration. A measuring device should be used to dispense drops and syrup. It is necessary to take the drug before meals, swallow the tablets whole, without chewing.

Codelac Neo tablets are prescribed only for adults - 1 pc. 2-3 times a day.

Recommended doses of Codelac Neo syrup depending on age:

• children 3–6 years old, 5 ml 3 times a day;
• children 6-12 years old - 10 ml 3 times a day;
• adolescents 12-18 years old - 15 ml 3 times a day;
• adults - 15 ml 4 times a day.

Recommended doses of Codelac Neo drops for children, depending on age:

• 2-12 months - 10 drops 4 times a day;
• 1-3 years - 15 drops 4 times a day;
• from 3 years old - 25 drops 4 times a day (it is possible to treat children under 2 years of age with the drug only after consulting a doctor).

1 ml (corresponds to 22 drops) contains 5 mg of butamirate.

Side effects

• on the part of the skin: exanthema;
• from the digestive system: diarrhea, nausea, vomiting;
• from the nervous system: dizziness (disappears after dose reduction or drug withdrawal), drowsiness;
• allergic reactions: skin rashes, itching.

Overdose

Symptoms: impaired coordination of movements, irritability, dizziness, decreased blood pressure, drowsiness, abdominal pain, diarrhea, nausea, vomiting.

Treatment: gastric lavage, intake of activated charcoal and saline laxatives, symptomatic therapy (if indicated).

special instructions

Each tablet of Codelac Neo contains 241 mg of lactose, therefore, in this dosage form, the drug is contraindicated for glucose-galactose malabsorption, lactase deficiency, lactose intolerance.

In the form of syrup and drops, Codelac Neo does not contain glucose and sucrose, therefore it can be used by patients with diabetes mellitus.

Influence on the ability to drive vehicles and complex mechanisms

Since there are known cases of dizziness and drowsiness during the treatment period, it is recommended to refrain from driving vehicles and performing activities that require quick psychophysical reactions and increased attention.

Application during pregnancy and lactation

There is no data on the passage of citrate butamirate through the placental barrier and on the safety of its use during pregnancy, therefore, Codelac Neo is contraindicated in the first trimester, and in the second and third trimesters it can be used if the expected benefit outweighs the potential risk.

It is not known whether butamirate citrate passes into breast milk, so it is not recommended for lactating women to take the drug.

Pediatric use

According to the instructions, Codelac Neo is contraindicated for children:

• in tablets - up to 18 years old;
• in the form of syrup - up to 3 years;
• in the form of drops - up to 2 months.

Drug interactions

The interaction of butamirate with other drugs has not been described.

In the course of treatment, it is recommended to refrain from drinking alcoholic beverages and taking drugs that depress the central nervous system, including tranquilizers, antipsychotics and hypnotics.

Analogs

Omnitus, Stopussin, Sinekod are analogues of Codelac Neo.

Terms and conditions of storage

Store no more than 2 years out of the reach of children with an ambient temperature of up to 25 ° C.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Codelac Neo

Reviews of Codelac Neo in syrup and tablet form are controversial. Some patients indicate that the drug is effective, inexpensive and relatively safe (it has few contraindications, practically does not cause side effects), others, on the contrary, write that in their case the remedy did not help to cope with the main problem, to eliminate which it is intended - to stop dry cough.

As for the drops of Codelac Neo, they are mainly reported by mothers who used the drug to treat dry cough in their children. Reviews about this dosage form are mostly positive; many attribute only the presence of ethanol to the disadvantages.

Price for Codelac Neo in pharmacies

Prices for Codelac Neo, depending on the form of release:

• coated tablets with modified release - 150–180 rubles per pack of 10;
• syrup - 130-165 rubles per 100 ml bottle; 225–255 rubles for a 200 ml bottle;
• drops for oral administration - 210–245 rubles per bottle of 20 ml.

Codelac Neo: prices in online pharmacies

Drug name Price Pharmacy

Codelac Neo 1.5 mg / ml syrup 100 ml 1 pc. RUB 150 Buy

Codelac NEO syrup 1.5mg / ml 100ml 170 RUB Buy

Codelac Neo 50 mg modified release film-coated tablets 10 pcs. 184 r Buy

Codelac Neo 5 mg / ml drops for oral administration 20 ml 1 pc. 258 r Buy

Codelac Neo 1.5 mg / ml syrup 200 ml 1 pc. 262 RUB Buy

Codelac NEO syrup 1.5mg / ml 200ml 269 r Buy

Codelac NEO drops for internal approx. 5mg / ml 20ml 324 r Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!