Pyrazidol
Pyrazidol: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. For violations of liver function
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Pyrazidolum
ATX code: N06AX
Active ingredient: pirlindole (pirlindole)
Producer: Pharmstandard-Leksredstva, JSC (Russia)
Description and photo update: 2019-20-08
Prices in pharmacies: from 139 rubles.
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Pyrazidol is a nootropic drug that improves cognitive functions, has a pronounced antidepressant activity, combining an activating effect on patients with apathetic anergic depression with anxiolytic and sedative effects on patients in agitated states.
Release form and composition
Dosage form of Pyrazidol - tablets: flat-cylindrical, from white to almost white with a greenish or light yellow tint, dosage 25 mg - with a chamfer, dosage 50 mg - with a chamfer and a score (10 pcs. In a contoured cell package, 1, 2 or 5 packs in a cardboard box; 50 tablets each in polymer cans, 1 can in a cardboard box).
The composition of 1 tablet includes:
- Active ingredient: pirlindole hydrochloride - 25 or 50 mg;
- Auxiliary components: milk sugar (lactose monohydrate), calcium stearate, potato starch, primellose (croscarmellose sodium).
Pharmacological properties
Pharmacodynamics
The antidepressant effect of Pyrazidol is provided by a combination of thymoleptic effect and a balanced effect on the central nervous system (CNS) of the active substance of the drug - pirlindole. The activating effect on patients with anergic, apathetic depression is combined with a sedative effect on patients in a state of agitation.
Pirindol: inhibits type A monoamine oxidase (MAO) selectively, transiently and reversibly; blocks the deamination of norepinephrine and serotonin to a high degree, tyramine to a lesser extent; partially inhibits the reuptake of monoamines; activates the processes of neurotransmission of nervous excitement in the central nervous system; has a nootropic effect, improving cognitive functions. The drug has no anticholinergic effect.
Indications for use
- Bipolar affective disorder (manic-depressive psychosis), schizophrenia;
- Depression of various origins, mainly with asthenic disorders and psychomotor retardation, with anxiety-depressive and / or anxious-delusional symptoms;
- Involutionary depression, which occurs at the age of 50-65, characterized by an extreme degree of fussiness and nervousness;
- Alcohol withdrawal;
- Alzheimer's disease (as part of combination therapy).
Contraindications
- Diseases of the hematopoietic system;
- Acute hepatitis;
- Simultaneous reception with monoamine oxidase inhibitors;
- Hypersensitivity to drug components.
Instructions for the use of Pyrazidol: method and dosage
Pyrazidol tablets are taken orally.
Recommended dosage regimen: the daily dose of 50-75 mg, divided into 2 doses, is gradually increased by 25-50 mg daily to 150-300 mg per day. Upon reaching the required therapeutic effect, the therapy is continued with the dose selected individually for 2-4 weeks, then the dose is gradually reduced.
Maximum allowable daily dose: 400 mg, divided into 2-3 doses.
Side effects
- Central and peripheral nervous system: dizziness, tremors;
- Digestive system: nausea, dry mouth;
- Other reactions: tachycardia, hyperhidrosis, allergic responses.
Overdose
There is no data.
special instructions
It is required to maintain a pause between the use of monoamine oxidase inhibitors (MAO) and taking Pyrazidol for at least 2 weeks.
Due to the absence of anticholinergic blocking effect in pirlindole, it is allowed to use the drug in patients with prostate adenoma and glaucoma.
Application during pregnancy and lactation
Due to the lack of adequate and well-controlled studies, there is no data on the safety and efficacy of using Pyrazidol during pregnancy and breastfeeding.
For violations of liver function
The drug is not prescribed for patients with acute hepatitis.
Drug interactions
According to the instructions, Pyrazidol is compatible with anxiolytics and antipsychotics.
Pirlindol is not prescribed simultaneously with procarbazine, furazolidone, selegiline, as well as with other MAO inhibitors.
Pyrazidol increases the effectiveness of epinephrine due to its antimonoamine oxidase activity.
Analogs
Pyrazidol analogues are: Simbalta, Alventa, Velaksin, Velbutrin SR, Venlaxor, Venlift, Gelarium Hypericum, Melitor, Deprivit, Mirzatel, Mirtel, Normazidol, Trittico.
Terms and conditions of storage
Keep out of reach of children, at temperatures up to 25 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Pirazidol
As one of the most inexpensive antidepressants, Pyrazidol, according to reviews, can also be called the optimal combination of effectiveness and cost. Depending on the clinical picture of the disease, the drug manifests itself in different ways, but in each situation the therapy was successful. Patients regain interest in life, positive thinking, control over the emotional state, increased efficiency, depression disappears. It is also recommended to use a drug to get out of a depressive state in the treatment of alcoholism.
Despite the fact that Pyrazidol is relatively well tolerated by the body, patients are advised to carefully select the dose and follow the prescribed dosage regimen to minimize the likelihood of adverse reactions.
Price for Pirazidol in pharmacies
The approximate price of Pyrazidol (tablets, 50 pcs. In a package) is: dosage 25 mg - 120-170 rubles; dosage 50 mg - 220-260 rubles.
Pyrazidol: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Pyrazidol 25 mg tablets 50 pcs. 139 RUB Buy |
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Pyrazidol 50 mg tablets 50 pcs. 225 RUB Buy |
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Pyrazidol tablets 50mg 50 pcs. 251 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
