Dicloran
Dicloran: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacodynamics and pharmacokinetics
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Prices in pharmacies
Latin name: Dicloran
ATX code: M02AA15
Active ingredient: Diclofenac (Diclophenacum)
Manufacturer: JBChemicals & Pharmaceuticals Ltd. (India)
Description and photo update: 2019-31-07
Prices in pharmacies: from 209 rubles.
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Dicloran is a drug with anti-inflammatory, antiaggregatory, analgesic and antipyretic effects.
Release form and composition
- Gel for external use 1% (20 or 50 g in aluminum or plastic tubes, 1 tube in a cardboard box);
- Solution for intramuscular administration (in ampoules of 3 ml, 25 ampoules in a cardboard box or 5 ampoules in plastic contour packs (pallets), 1 pallet in a cardboard box);
- Enteric-coated tablets (10 pcs. In blisters, 2 or 10 packs in a cardboard box).
The preparation contains an active substance:
- 1 g of gel for external use: diclofenac - 10 mg (as diethylamine);
- 1 ml solution for injection: diclofenac sodium - 75 mg;
- 1 tablet: diclofenac sodium - 50 mg.
Pharmacodynamics and pharmacokinetics
Dicloran belongs to non-steroidal anti-inflammatory drugs. The active substance of the drug - diclofenac - indiscriminately inhibits type 1 and type 2 cyclooxygenase, which leads to a disruption in the metabolism of arachidonic acid (an enzyme of COX) and the synthesis of prostaglandins, provoking the development of the inflammatory process, fever and pain. The use of Dicloran in rheumatic diseases allows you to get rid of morning stiffness of the joints, eliminate pain in the joints during physical exertion and at rest, and increase the range of joint movements.
The drug effectively eliminates pain syndrome, as well as inflammation and swelling that occur after injuries and in the postoperative period. Its analgesic effect is due to the central (as a result of inhibition of the synthesis of prostaglandins in the central and peripheral nervous system) and peripheral (indirectly, by suppressing the production of prostaglandins) mechanism.
With prolonged therapy, the agent reduces platelet aggregation, has a desensitizing effect, and is also an inhibitor of proteoglycan synthesis in cartilage.
When taken orally, tablets are absorbed from the digestive tract at a high rate. Food decreases the rate of absorption, but does not change the degree of absorption of diclofenac. The maximum concentration of the substance in the blood after taking the tablets is reached 2-4 hours after taking the tablets. Diclofenac is metabolized in the liver, forming several metabolites, but there is no cumulative effect. Its connection with blood proteins (in particular, albumin) is high and reaches 99.7%. Also, the substance is contained in the synovial fluid, and its half-life from the blood is 1-2 hours. Approximately 60% of the dose is excreted through the kidneys as metabolic products, and the rest as metabolites in the bile.
When applied topically, Dicloran gel is rapidly absorbed and penetrates into the subcutaneous layers of fiber, muscle tissue and joint capsule, providing a decrease or disappearance of pain in the joints during movement and at rest.
Indications for use
- Degenerative and inflammatory diseases of the musculoskeletal system (ankylosing spondylitis, rheumatoid arthritis, spondyloarthrosis, osteoarthritis and other diseases);
- Acute gouty arthritis;
- Rheumatic diseases of the periarticular soft tissues;
- Postoperative inflammatory and pain syndrome;
- Spinal pain;
- Injuries;
- Gynecological diseases;
- Biliary or renal colic.
Contraindications
- Rhinitis, urticaria and bronchospasm associated with the use of non-steroidal anti-inflammatory drugs in history;
- Violation of hematopoiesis of unknown origin;
- Erosive and ulcerative lesions of the gastrointestinal tract in the acute stage;
- Pregnancy and lactation (lactation);
- Age under 18;
- Hypersensitivity to drug components.
Instructions for the use of Dicloran: method and dosage
Depending on the form, the agent is applied orally, intramuscularly, topically.
The drug is injected intramuscularly for no more than 2 days deep into the muscle at a dose of 75 mg per day (in severe cases, it is possible to administer the solution 2 times a day with a break of several hours at the same dose). Then you should switch to oral administration.
Inside, the tablets are taken without chewing and drinking plenty of liquid. It is preferable to take the drug before meals (with hypersensitivity of the stomach, it is possible to use the drug at the end or after meals). The daily dose is 100-150 mg, the frequency of use is 2-3 times a day.
Dicloran gel is applied topically by applying a strip the size of a hazelnut or cherry and rubbing lightly. The drug is applied over the painful area to intact skin 3-4 times a day.
Side effects
During therapy, it is possible to develop disorders on the part of some body systems, manifested with different frequencies:
- Nervous system and sensory organs: increased fatigue, dizziness, headache; in rare cases - irritability, tinnitus, anxiety, sleep disturbances, mental disorders, depression, diplopia, blurred vision, convulsions;
- Cardiovascular system and blood (hemostasis, hematopoiesis): in some cases - leukopenia, thrombocytopenia, anemia, agranulocytosis; in isolated cases - tachycardia, chest pain, increased blood pressure;
- Organs of the gastrointestinal tract: decreased appetite, flatulence, cramps and pain in the epigastric region, abnormal liver function, including hepatitis; rarely - erosive and ulcerative lesions with perforation and bleeding, esophagitis, aphthous stomatitis; in some cases - Crohn's disease, ulcerative colitis;
- Genitourinary system: rarely - edema; in some cases - nephrotic syndrome, proteinuria, hematuria, acute renal failure, interstitial nephritis;
- Skin: urticaria, Lyell's syndrome, skin rash, eczema, bullous rashes, Stevens-Johnson syndrome, alopecia, erythroderma, photosensitivity;
- Others: seal; in some cases - necrosis or abscess at the injection site, redness, tingling or burning sensation when applied topically; rarely - systemic allergic reactions, attacks of bronchial asthma.
Overdose
When Dicloran gel is applied topically, the extremely low systemic absorption of Diclofenac makes overdose almost impossible.
When taking oral tablets, an overdose can be determined by the following symptoms:
- oppression of the respiratory center;
- headache and dizziness;
- renal dysfunction;
- nausea and vomiting;
- pain in the stomach;
- myoclonic seizures;
- clouded consciousness;
- bleeding.
special instructions
Before starting treatment, as well as in cases of development of uncharacteristic symptoms during the period of therapy, you should consult your doctor.
Application during pregnancy and lactation
According to the instructions, Dicloran is prohibited from taking in the third trimester of pregnancy. Appointment in the I and II trimesters of pregnancy is possible only after consultation with a specialist.
There are no reliable data on the effectiveness and safety of the drug during lactation.
Drug interactions
There are no data on the interaction of diclofenac with other drugs.
Analogs
Analogs of Dicloran are: Diclac, Diclofenac, Diclofenac Retard, Diclofenac-Akos, Diklovit, Diclobene, Dicloberl, Diclonac, Decaloge, Diclotard, Voltaren, Voltaren Emulgel, Voltaren Retfentoz, Naklofin
Terms and conditions of storage
Store in a dark place, out of reach of children, at temperatures up to 30 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Dicloran
In most cases, the reviews about Dicloran are positive, although there are some nuances. In practice, the drug is successfully used in the treatment of various diseases of the musculoskeletal system. The most commonly used gel is Dicloran, which many patients call "Dicloran ointment". The effectiveness of the drug is quite high and allows you to stop pain and eliminate the inflammatory process. Injections with a solution for intramuscular administration of Dicloran successfully alleviate the patient's condition with pain in the shoulder joint or exacerbation of osteochondrosis.
The cost of the drug remains affordable for the general population. However, in many cases, oral administration of tablets is accompanied by rapidly onset stomach pain. In this case, it is recommended to combine drug therapy with Omez.
Prices for Dicloran in pharmacies
The average price for Dicloran in the form of a gel is 186 rubles for 1 tube of 20 g. Buy a pack of tablets in the amount of 20 pcs. in pharmacies you can on average for 136 rubles. There is no solution in most pharmacies.
Dicloran: prices in online pharmacies
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Drug name Price Pharmacy |
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Dicloran plus gel for external use 30 g 1 pc. 209 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
