Vairova
Instructions for use:
- 1. Release form and composition
- 2. Indications for use
- 3. Contraindications
- 4. Method of application and dosage
- 5. Side effects
- 6. Special instructions
- 7. Drug interactions
- 8. Analogs
- 9. Terms and conditions of storage
- 10. Terms of dispensing from pharmacies
Prices in online pharmacies:
from 649 rub.
Buy
Vairova is an antiviral drug, blocker of viral DNA synthesis and viral replication.
Release form and composition
Dosage form of the drug - film-coated tablets: from light blue to blue, biconvex, oval, with a line on one side, on the sides of which the engraving V | 5 and notches; in the cross section, two layers are distinguished - a blue shell and a white core with blue blotches (10 pieces in blisters, in a cardboard box 1–4 blisters).
1 tablet contains:
- active substance: valacyclovir (in the form of hydrochloride) - 500 mg (556.275 mg);
- auxiliary components: crospovidone, povidone, microcrystalline cellulose, magnesium stearate, indigo carmine dye, purified water (evaporates during the production process);
- film shell: Opadray 02C50740 blue dye (indigo carmine dye, titanium dioxide, hypromellose 5 cP, polysorbate 80, macrogol / PEG), purified water (evaporates during production).
Indications for use
Vairova's drug is used in adult patients for the treatment of primary and recurrent herpes of the lips and genital herpes, long-term suppressive therapy of recurrent genital herpes in patients with immunodeficiency, including the human immunodeficiency virus (HIV), reducing the risk of infection of a sexual partner, and treatment of herpes zoster.
For the prevention of cytomegalovirus (CMV) infection during organ transplantation, the drug is prescribed to adult patients and children over 12 years old.
Contraindications
Absolute:
- HIV infection with a CD4 + lymphocyte count <100 / μl;
- children under 12 years of age (CMV prevention);
- children and adolescents up to 18 years old (in other cases);
- increased individual sensitivity to drug components.
Relative (Vairov's drug is used with caution):
- liver / kidney dysfunction;
- the period of pregnancy and breastfeeding;
- dehydration of the body (hypohydration);
- combined use with nephrotoxic drugs / substances;
- elderly age.
Method of administration and dosage
Vairov's tablets are taken orally, regardless of the meal.
Treatment of adult patients
The following dosage is recommended depending on the disease / condition:
- herpes zoster (treatment): 1000 mg 3 times / day, course duration - 7 days;
- diseases caused by the Herpes simplex virus (treatment): 2 times / day, 500 mg, the duration of the course of therapy for relapses is 3-5 days; treatment of more severe primary episodes should be started as early as possible, the duration of the course should be increased to 10 days. In case of re-infection, it is optimal to start taking valacyclovir in the prodromal period, or after the first symptoms of the disease;
- labial herpes (labial fever, herpes of the lips, "cold") (alternative treatment): 2 times / day, 2000 mg, the optimal interval between doses is 12 hours, the minimum is 6 hours, the course duration is 1 day, further administration of valacyclovir has clinical benefits additionally does not. It is necessary to start treatment at the earliest symptoms of the disease, such as itching, tingling, burning;
- relapses of diseases caused by the Herpes simplex virus (suppressive therapy / prophylaxis): 1 time / day, 500 mg (with normal immunity), 2 times / day, 500 mg (with immunodeficiency), course duration - 4-12 months.
Correction of the dosage regimen depending on the indications and creatinine clearance (CC):
- herpes zoster: CC 15-30 ml / min - 2 times / day at 1000 mg, CC <15 ml / min - 1 time / day at 1000 mg;
- diseases caused by the Herpes simplex virus: CC <15 ml / min - 1 time / day, 500 mg;
- labial herpes: CC 31-49 ml / min - 2 times / day at 1000 mg, CC 15-30 ml / min - 2 times / day at 500 mg, CC <15 ml / min - 500 mg once;
- relapses of diseases caused by the Herpes simplex virus (suppressive therapy / prevention): 1 time / day, 250 mg (with normal immunity), 1 time / day, 500 mg (with immunodeficiency);
- reducing the risk of infection with genital herpes: CC <15 ml / min - 1 time / day, 250 mg.
Patients on hemodialysis are recommended to take valacyclovir immediately after the end of the session, at the dose recommended for patients with CC <15 ml / min.
Prevention of CMV in adults and adolescents over 12 years old
In order to prevent CMV infection, it is recommended to take 2,000 mg 4 times / day. After the transplant operation, the drug is prescribed as early as possible. The duration of the course is 90 days; with a high risk of developing infections, it can be increased.
Correction of the dosage regimen depending on QC:
- CC> 75 ml / min: 4 times / day, 2000 mg;
- CC 50-75 ml / min: 4 times / day, 1500 mg;
- CC 25-50 ml / min: 3 times / day, 1500 mg;
- CC 10-25 ml / min: 2 times / day, 1500 mg;
- CC <10 ml / min (hemodialysis): 1 time / day, 1500 mg.
Frequent monitoring of QC and, due to changes in its parameters, dose adjustment are especially relevant during the period of rapidly changing renal function (immediately after transplantation or after graft engraftment).
Side effects
- gastrointestinal tract (GIT): often - nausea; infrequently - diarrhea, vomiting, abdominal pain; rarely - an increase in liver enzymes (alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase); in isolated cases - hepatitis;
- blood and lymphatic system: in isolated cases - leukopenia, thrombocytopenia (leukopenia is mainly detected in patients with immunodeficiency);
- immune system: in isolated cases - anaphylaxis;
- nervous system: often - headache; rarely - disturbance / confusion of consciousness, dizziness, loss of consciousness, hallucinations; in isolated cases - agitation, ataxia, tremor, dysarthria, convulsions, encephalopathy, psychotic symptoms, coma;
- respiratory system and organs of the chest cavity: infrequently - shortness of breath;
- hepatobiliary system: in isolated cases - a reversible increase in the indicators of functional liver tests, sometimes equated to hepatitis;
- skin and subcutaneous tissues: infrequently - skin rashes, including increased sensitivity to visible or ultraviolet radiation (photosensitization); rarely - itching; in isolated cases - urticaria, angioedema;
- kidneys and urinary system: rarely - renal dysfunction; in isolated cases - acute renal failure;
- other reactions: sporadic data on microangiopathy, renal failure, thrombocytopenia and hemolytic anemia (sometimes in combination) in severely immunocompromised patients, especially in the late stages of HIV infection, who received high-dose valacyclovir therapy (up to 8000 mg per day) for a long time time.
Symptoms of a Vairov overdose include nausea / vomiting, acute renal failure, and neurological side effects including agitation, hallucinations, confusion, loss of consciousness, and coma. In order to prevent overdose, valacyclovir should be used with caution, especially in elderly patients and with impaired renal function, in a timely manner reducing the dose of the drug by the required amount. For the treatment of the condition, the optimal procedure is hemodialysis, which promotes the accelerated elimination of acyclovir from the blood. In order to diagnose intoxication in a timely manner, careful monitoring of patients is required.
special instructions
Neurological symptoms during therapy with valacyclovir are predominantly reversible; they are noted in most cases in patients with renal failure and other risk factors. After organ transplantation, in patients receiving Vairov's tablets for the prevention of cytomegalovirus infection in high doses (up to 8000 mg per day), side effects from the nervous system occur more often than in those who receive lower doses.
With dehydration and elderly patients during therapy with valacyclovir, it is required to increase the amount of fluid consumed. Due to the fact that valacyclovir is excreted from the body by the kidneys, if their function is impaired and in elderly patients (due to a possible deterioration of the kidney function), a decrease in the dose of the drug is required. No correction of the dosage regimen is required if there are no pronounced renal dysfunctions. With a history of kidney pathologies, the risk of developing nephrological complications increases. In order to identify them in a timely manner, it is important to carefully monitor this category of patients.
Suppressive therapy reduces the risk of transmission of genital herpes, but it does not completely cure herpes infection, and does not exclude the possibility of transmission of the virus, therefore it is recommended to avoid unprotected sexual intercourse.
In case of side effects from the nervous system (including agitation, hallucinations, confusion, delirium, convulsions and encephalopathy), the drug must be canceled.
Drug interactions
Since acyclovir (a metabolite of valacyclovir) is predominantly excreted by active tubular secretion in the urine unchanged, all drugs with the same excretion mechanism, when used together, can increase the plasma concentration of acyclovir.
Cimetidine and probenecid increase the AUC of acyclovir, reducing its renal clearance, but with their simultaneous use, there is no need to adjust the dose, due to the wide therapeutic index of acyclovir.
Valacyclovir is taken with caution in high doses of ≥ 4 g / day in order to prevent cytomegalovirus infection in combination with drugs competing for excretion with acyclovir. Such combined use can lead to an increase in plasma levels of one or both drugs, as well as their metabolites. So the simultaneous administration of mycophenolate mofetil increases the plasma concentration of acyclovir and mycophenolate (an inactive metabolite of mofetil).
Also, with caution, simultaneously with Vairov's drug in high doses, other drugs that affect kidney function, for example, cyclosporine or tacrolimus, are prescribed.
Analogs
The analogues of Vairova's drug are: Valavir, Valtrex, Valacyclovir, Valtsikon, Valvir, Virdel, Valmik.
Terms and conditions of storage
Store out of the reach of children at a temperature not exceeding 30 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Vairova: prices in online pharmacies
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Drug name Price Pharmacy |
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Vairova 500 mg film-coated tablets 10 pcs. 649 r Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
