Piperazine Adipate - Instructions For Use, Price, Reviews, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Piperazine adipate

Piperazine adipate: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. Drug interactions
13. 13. Analogs
14. 14. Terms and conditions of storage
15. 15. Terms of dispensing from pharmacies
16. 16. Reviews
17. 17. Price in pharmacies

Latin name: Piperazini adipinas

ATX code: P02CB01

Active ingredient: piperazine adipinate (piperazine adipinate)

Producer: Sintez, JSC (Russia)

Description and photo update: 2018-21-11

Piperazine adipate is an anthelmintic agent.

Release form and composition

Dosage form - tablets: flat-cylindrical, almost white or white, with a chamfer and a risk (10 pcs. In blister / non-junction packs, in a cardboard box 1 package; for hospitals - in a cardboard box, 200 blister-free contour packs).

Composition of 1 tablet:

• active substance: piperazine adipate (piperazine adipate) - 0.5 g;
• additional components: sodium carboxymethyl starch (sodium starch glycolate), calcium stearate, talc, corn starch.

Pharmacological properties

Pharmacodynamics

Piperazine adipate is an anthelmintic agent that has a paralyzing effect on nematodes. The mechanism of its action is due to the ability to cause muscle paralysis and disrupt the function of the neuromuscular system of nematodes.

The drug is most effective for enterobiasis and ascariasis.

Pharmacokinetics

Piperazine adipate is a low-toxic agent. The drug does not destroy worms, therefore there is no danger of absorption of toxic products of their decay.

The effectiveness of deworming is 90–95%, with repeated use it can reach 100%.

Indications for use

According to the instructions, Piperazine adipate is used for enterobiasis and ascariasis (infestations by pinworms and roundworms, respectively).

Contraindications

• chronic renal failure;
• organic diseases of the central nervous system;
• children under 3 years old;
• hypersensitivity to any component of the drug.

Instructions for the use of Piperazine adipate: method and dosage

The drug is indicated for oral administration. The tablets should be taken 2 times a day 60 minutes before meals or 30-60 minutes after meals. With ascariasis, it is possible to prescribe an alternative one-day therapy regimen: 0.4-4 g once or 0.2-2 g 2 times a day. The exact dose is determined by the doctor depending on the age of the patient.

Recommended single doses:

• adults and adolescents from 15 years old - 1.5-2 g;
• children 13-15 years old - 1.5 g;
• children 9-12 years old - 1 g;
• children 6-8 years old - 0.75 g;
• children 4-5 years old - 0.5 g;
• children 3-4 years old - 0.3 g

With ascariasis, the course of treatment is 2 days.

With enterobiasis, the duration of treatment is 5 days. In total, 1–3 courses are carried out at intervals of 7 days.

To remove pinworms from the rectum between courses of treatment, enemas should be put at night from 1-3 glasses of solution: ½ teaspoon of baking soda (sodium bicarbonate) per 1 glass of water.

Side effects

During treatment, headaches, nausea and abdominal pain of a spastic nature are possible.

Patients with renal failure are at risk of developing neurotoxic complications, such as blurred vision, hallucinations, euphoria, tremors, muscle weakness, and impaired coordination of movements.

Overdose

An overdose of piperazine adipate may present with muscle weakness and tremors. In this case, gastric lavage, intake of enterosorbent (for example, activated carbon) and saline laxatives are indicated. Thiamine is prescribed for neurological disorders. If necessary, oxygen and transfusion therapy is performed.

special instructions

Treatment with the drug is carried out on an outpatient basis.

No special preparation is required prior to prescribing piperazine adipate. There is also no need to follow a special diet during treatment. Laxatives should only be taken by constipated patients.

During the period of therapy, a strict hygienic regime should be observed.

Influence on the ability to drive vehicles and complex mechanisms

No information available.

Application during pregnancy and lactation

No information available.

Pediatric use

The drug is not prescribed for children under 3 years of age because of the tablet dosage form.

With impaired renal function

Chronic renal failure is a contraindication to the use of the drug.

Drug interactions

Piperazine adipate may increase the severity of extrapyramidal disorders in patients receiving chlorpromazine.

Analogs

An analogue of Piperazine adipate is the drug Piperazine.

Terms and conditions of storage

Shelf life is 4 years.

Store at a temperature not exceeding 25 ° C in a dry place out of the reach of children.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about piperazine adipate

According to reviews, Piperazine adipate is an effective mild anthelmintic agent that is well tolerated, does not require special preparation, diet and / or laxatives. Additional benefits include a short course of treatment, affordability and low cost. Many people note that the drug is effective in treating both humans and pets.

There are reviews of pregnant and breastfeeding women, whom the doctor prescribed this remedy as the most harmless among many modern anthelmintic drugs.

Some patients consider the only disadvantage that the helminths come out alive (piperazine adipate only paralyzes them).

Price for Piperazine adipate in pharmacies

The price for Piperazine adipate is 10–20 rubles per pack of 10 tablets.

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!