Sinekod

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Sinekod: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. Drug interactions
12. Analogs
13. Terms and conditions of storage
14. Terms of dispensing from pharmacies
15. Reviews
16. Price in pharmacies

Latin name: Sinecod

ATX code: R05DB13

Active ingredient: Butamirate

Manufacturer: NOVARTIS CONSUMER HEALTH, Switzerland

Description and photo update: 2019-07-08

Prices in pharmacies: from 173 rubles.

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Sinekod is an antitussive agent.

Release form and composition

syrup (vanilla): colorless transparent liquid with the smell of vanilla (100 and 200 ml each in dark glass bottles, in a cardboard box 1 bottle complete with a measuring cap);
drops for oral administration (for children): clear liquid, colorless or with a yellowish tinge, with a vanilla smell (20 ml each in dark glass vials equipped with a dropper dispenser and a first opening control system, in a cardboard box 1 bottle).

The active substance is butamirate citrate:

1 ml of syrup - 1.5 mg;
1 ml drops - 5 mg.

Excipients of the syrup: water, benzoic acid, sodium saccharinate, glycerol, sorbitol solution 70%, ethanol 96%, vanillin, sodium hydroxide 30%.

Additional components of drops: sorbitol solution 70%, ethanol 96%, benzoic acid, sodium saccharinate, glycerol, sodium hydroxide 30%, vanillin, water.

Pharmacological properties

Pharmacodynamics

The active component of Sinekod is butamirate, which is part of the group of centrally acting antitussives. This substance does not belong to the opium alkaloids either from a chemical or pharmacological point of view and does not lead to the formation of addiction or dependence.

Butamirate suppresses cough by directly affecting the cough center. Sinekod is characterized by a bronchodilatory (bronchodilatory) effect and facilitates breathing, improving blood oxygenation (oxygen saturation) and spirometry (airway resistance decreases).

Pharmacokinetics

The ester of butamirate is rapidly and almost completely absorbed and hydrolyzed in plasma to form diethylaminoethoxyethanol and 2-phenylbutyric acid. Studies concerning the relationship between food intake and absorption of the active substance of Sinekod have not been conducted. When taking doses of 22.5–90 mg, the content of diethylaminoethoxyethanol and 2-phenylbutyric acid changes in direct proportion to the amount of the drug taken.

Butamirate is detected in the blood already 5-10 minutes after oral administration of doses of 22.5, 45, 67.5 and 90 mg. With a treatment regimen that includes taking the drug in any of the above dosages, the maximum plasma concentration is reached within 1 hour. When a dose of 90 mg is taken orally, the butyrate content in the blood is 16.1 ng / ml.

The average plasma level of 2-phenylbutyric acid is reached within 1.5 hours. The maximum substance content of 3052 ng / ml was observed after taking a dose of 90 mg. The average plasma concentration of diethylaminoethoxyethanol is reached within 0.67 hours with a maximum concentration of 160 ng / ml recorded after taking a dose of 90 mg.

Butamirate is distinguished by a large volume of distribution in the range of 81–112 liters (it is necessary to take into account the correction for body weight in kg), and also almost completely binds to plasma proteins. 2-phenylbutyric acid is characterized by a high degree of binding to plasma proteins at all dosage levels (22.5–90 mg). On average, it varies in the range of 89.3–91.6%. Diethylaminoethoxyethanol binds to plasma proteins by 28.8–45.7%. There are no exact data on whether butamirate crosses the placental barrier or into breast milk.

The rate of butamirate hydrolysis is extremely high. The 2-phenylbutyric acid formed as a result of this process is further partially metabolized by hydroxylation in the para position.

All metabolites are excreted mainly through the kidneys. Those of them that have an acidic reaction, after conjugation in the liver, mainly bind to glucuronic acid. The content of conjugates of 2-phenylbutyric acid in urine is significantly higher than in blood plasma. Butamirate is detected in urine within 48 hours after taking Sinekod. With a 96-hour sampling period, the share of this substance excreted in urine accounts for approximately 0.02, 0.02, 0.03 and 0.03% of the doses taken 22.5, 45, 67.5 and 90 mg, respectively …

Butamirate is excreted in the urine mainly in the form of diethylaminoethoxyethanol, the level of which is significantly higher than unconjugated 2-phenylbutyric acid or butamirate in unchanged form.

The half-life of butamirate, 2-phenylbutyric acid and diethylaminoethoxyethanol is 1.48-1.93, 23.26-24.42 and 2.72-2.9 hours, respectively.

Indications for use

Sinekod is used for the symptomatic treatment of dry cough of various etiology: with whooping cough, during bronchoscopy and surgical interventions, if necessary, suppressing cough in the pre- and postoperative period.

Contraindications

I trimester of pregnancy;
lactation period;
children up to 2 months - for drops, up to 3 years - for syrup;
hypersensitivity to drug components.

With care: II and III trimesters of pregnancy.

Instructions for the use of Sinekod: method and dosage

The drug must be taken orally before meals.

Recommended doses of syrup:

children 3–6 years old - 5 ml 3 times a day;
children 6-12 years old - 10 ml 3 times a day;
adolescents 12-18 years old - 15 ml 3 times a day;
adults - 15 ml 4 times a day.

For ease of dispensing, a measuring cap is provided with the bottle. It should be washed and dried after each use.

Recommended doses of Sinekod drops for children, depending on age:

2-12 months - 10 drops 4 times a day;
1-3 years - 15 drops 4 times a day;
over 3 years old - 25 drops 4 times a day.

The duration of therapy is no more than 7 days.

If you need to treat children under 2 years of age, you should consult your doctor.

Side effects

The drug is generally well tolerated. In rare cases (> 1/10 000, <1/1000), the following side effects occur:

from the central nervous system: drowsiness, dizziness;
from the digestive system: diarrhea, nausea;
on the part of the skin: exanthema;
others: allergic reactions.

Overdose

Overdose symptoms are: nausea, vomiting, drowsiness, diarrhea, dizziness, a sharp drop in blood pressure. There is no specific antidote. Treatment of an overdose consists of gastric lavage, the appointment of activated charcoal and therapy that supports vital body functions.

special instructions

During treatment, expectorant drugs should not be taken, since this can lead to the accumulation of phlegm in the respiratory tract and, as a result, the development of respiratory tract infections and bronchospasm.

In the form of syrup, Sinekod can be taken by patients with diabetes mellitus, since it contains saccharin and sorbitol as sweeteners.

According to the instructions, Sinekod can cause drowsiness, which should be taken into account by vehicle drivers and patients employed in potentially hazardous industries associated with increased concentration.

Application during pregnancy and lactation

Reliable clinical studies of the safety and efficacy of Sinekod for pregnant women have not been carried out, therefore, it is not recommended to prescribe the drug in the first trimester of pregnancy. In the II and III trimesters, the use of Sinecod is allowed if the benefits to the mother outweigh the potential risk to the fetus.

Since there are no data on the excretion of butamirate in breast milk, taking the drug during lactation is undesirable.

Animal studies have not shown any toxic effects of butamirate on the fetus.

Pediatric use

For children, Sinekod is contraindicated: at the age of up to 2 months - in the form of drops, up to 3 years - in the form of a syrup.

Drug interactions

No information available.

Analogs

Sinekod's analogues are: Codelac Neo, Omnitus, Erespal, Stopussin, Libeksin, Fluditek, Ascoril, Panatus Forte.

Terms and conditions of storage

Store at temperatures up to 30 ° C out of reach of children.

The shelf life is 5 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Sinekod

Reviews of Sinekod in the form of syrup are mostly favorable. Patients indicate that it does help with dry coughs, with no serious side effects. Many doctors prescribe this drug, which, with a properly selected scheme, causes a positive dynamics of the disease.

Opinions about the drops are controversial. Some patients claim that the drug has proved to be indispensable in the treatment of cough attacks, while others insist that it only suppresses cough, but does not cure it.

Sinekod price in pharmacies

The price of Sinekod syrup is approximately 400–450 rubles (in a 200 ml bottle) and 270–310 rubles (in a 100 ml bottle). Drops can be purchased at pharmacies for 400–445 rubles (for a 20 ml bottle).

Sinekod: prices in online pharmacies

Drug name

Price

Pharmacy

Sinekod 1.5 mg / ml vanilla flavored syrup 100 ml 1 pc.

173 r

Buy

Sinecod syrup 1.5mg / ml 100ml n1

196 r

Buy

Sinekod 5 mg / ml oral drops for children 20 ml 1 pc.

287 r

Buy

Sinekod 1.5 mg / ml vanilla flavored syrup 200 ml 1 pc.

292 r

Buy

Sinecod syrup 1.5mg / ml 200ml n1

RUB 300

Buy

Sinecod Sinecod for dry cough, drops for oral administration, 20ml

302 RUB

Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!