Lazolvan Syrup For Children

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Lazolvan syrup for children: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use aged
11. In case of impaired renal function
12. For violations of liver function
13. Drug interactions
14. Analogs
15. Terms and conditions of storage
16. Terms of dispensing from pharmacies
17. Reviews
18. Price in pharmacies

Latin name: Lasolvan

ATX code: R05CB06

Active ingredient: Ambroxol (Ambroxol)

Manufacturer: Boehringer Ingelheim Ellas (Greece), Instituto De Angeli (Italy), Bolder Arzneimittel GmbH & Co. KG (Germany), Delpharm Reims (France)

Description and photo update: 2018-23-10

Prices in pharmacies: from 188 rubles.

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Lazolvan syrup for children is an expectorant mucolytic agent.

Release form and composition

The dosage form of Lazolvan for children is syrup: slightly viscous, colorless or almost colorless, transparent or almost transparent liquid with the smell of wild berries (100 or 200 ml in dark glass bottles, complete with a measuring cup, 1 bottle in a cardboard box).

Composition of 5 ml syrup:

active substance: ambroxol hydrochloride - 15 mg;
auxiliary components: purified water - 3047.5 mg, liquid sorbitol (non-crystallizing) - 1750 mg, glycerol 85% - 750 mg, forest berry flavor PHL-132195 - 11 mg, hyetellose (hydroxyethyl cellulose) - 10 mg, benzoic acid - 8, 5 mg, potassium acesulfame 5 mg, vanilla flavor 201629 3 mg.

Pharmacological properties

Pharmacodynamics

The active ingredient of Lazolvan is ambroxol - a substance that increases secretion in the respiratory tract. It enhances the production of pulmonary surfactant and stimulates ciliary activity, resulting in increased mucus flow and transport (mucociliary clearance). As a result, sputum discharge improves, coughing is relieved.

In patients with chronic obstructive pulmonary disease (COPD) with long-term treatment with Lazolvan (for at least 2 months), there is a significant decrease in exacerbations of the disease, namely, their duration and the number of days of antibiotic therapy.

Pharmacokinetics

Lazolvan syrup for children is characterized by rapid and almost complete absorption with a linear dependence on the dose of ambroxol within the therapeutic range of concentrations. After oral administration, the maximum concentration of ambroxol reaches after 1–2.5 hours. The volume of distribution is 552 liters. It has a high ability to bind to plasma proteins - about 90%. After oral administration, it quickly passes from the blood into the tissues, forming the highest concentrations in the lungs. About 30% of the oral dose of the drug is exposed to the effect of the primary passage through the liver. According to studies on human liver microsomes, the isoenzyme CYP3A4 is the predominant isoform responsible for the metabolism of ambroxol to dibromantranilic acid. The rest of the active substance Lazolvan is metabolized in the liver,mainly through glucuronidation and partial cleavage to dibromantranilic acid (about 10% of the dose taken) and a small amount of additional metabolites.

The half-life (T½) of ambroxol is 10 hours. Total clearance is approximately 660 ml / min, with renal clearance accounting for 8% of this.

Using the method of radioactive labeling, it is calculated that after taking one dose of ambroxol for the next 5 days, about 83% is excreted in the urine.

There is no need to select the dose of Lazolvan syrup for children depending on gender, since these data do not have a clinically significant effect on the pharmacokinetics of Ambroxol.

Indications for use

According to the instructions, Lazolvan syrup for children is used to treat acute and chronic respiratory diseases, accompanied by the release of viscous sputum, such as:

acute and chronic bronchitis;
chronic obstructive pulmonary disease;
bronchiectasis;
bronchial asthma with difficulty in sputum discharge;
pneumonia.

Contraindications

I trimester of pregnancy;
lactation period;
increased sensitivity to any component of the drug.

In the following cases, cautious use of Lazolvan syrup for children is shown:

renal and / or hepatic impairment;
II and III trimesters of pregnancy.

Instructions for the use of Lazolvan children's syrup: method and dosage

The mucolytic agent is taken orally. Food intake does not affect the effectiveness of Ambroxol.

Doses to be administered:

children under 2 years old - 2.5 ml 2 times / day;
children 2-6 years old - 2.5 ml 3 times / day;
children 6-12 years old - 5 ml 2-3 times / day;
adolescents from 12 years old and adults - 10 ml 3 times a day.

If no improvement is noted within 4-5 days, a doctor's consultation is required.

Side effects

Classification of the registered side effects by the frequency of their development: often - 1-10%, infrequently - 0.1-1%, rarely - 0.01-0.1%.

Possible adverse reactions while taking Lazolvan baby syrup:

from the gastrointestinal tract: often - decreased sensitivity in the mouth / pharynx, nausea; infrequently - dry mouth, abdominal pain, vomiting, dyspepsia, diarrhea; rarely - dry throat;
from the nervous system: often - taste disorders (dysgeusia);
from the skin, subcutaneous tissues and the immune system: rarely - urticaria, skin rash, itching, angioedema, anaphylactic reactions (including anaphylactic shock), hypersensitivity reactions.

Overdose

Symptoms of an ambroxol overdose are diarrhea, abdominal pain, indigestion, nausea, and vomiting.

Within 1-2 hours after taking an overdose, it is advised to induce vomiting and wash out the stomach. In the future, in the event of unwanted symptoms, symptomatic therapy is performed.

special instructions

When using Lazolvan for children, antitussives should not be taken, since they make it difficult for sputum to pass.

There are isolated reports of the occurrence of such severe skin lesions as toxic epidermal necrolysis and malignant exudative erythema, which coincided with the use of Ambroxol. Most often they are explained by the severity of the disease and / or concomitant other therapy. In such cases, at an early stage, an increase in body temperature, sore throat, cough, rhinitis, body pain are possible. With these symptoms, cold remedies may be mistakenly prescribed. In this regard, patients are advised to immediately stop taking Lazolvan and seek medical help if any new lesions appear on the body or mucous membranes.

Influence on the ability to drive vehicles and complex mechanisms

Studies on the effect of ambroxol on a person's ability to engage in potentially hazardous activities that require increased attention and speed of psychophysical reactions (including driving a car) have not been conducted. No cases of negative influence were reported.

Application during pregnancy and lactation

It has been reliably established that Ambroxol penetrates the placental barrier, however, in the course of preclinical studies, there was no negative effect of the drug (neither direct nor indirect) on the course of pregnancy, labor, embryonic / fetal and postnatal development of the fetus / child. There is extensive clinical experience with ambroxol after the 28th week of pregnancy, which indicates that there is no negative effect on the fetus. Nevertheless, it is not recommended to take Lazolvan syrup for children in the first trimester of pregnancy, and in the second and third trimesters, it is possible to take it only as directed by a doctor who will assess the balance of benefits and potential risks.

Ambroxol may be excreted in breast milk. Although no adverse effects have been found in breastfed babies, it is not recommended for nursing women to take the drug.

In preclinical studies of ambroxol, no negative effects on fertility have been identified.

Pediatric use

The drug can be used in childhood, including early childhood, according to indications, in accordance with the doctor's recommendations.

With impaired renal function

Ambroxol should be used with caution and only as directed by a doctor for impaired renal function.

For violations of liver function

Ambroxol should be used with caution and only as directed by a physician for liver failure.

Drug interactions

Cases of clinically significant adverse reactions of the interaction of Ambroxol with other drugs are unknown.

The drug increases the penetration of certain antibiotics into the bronchial secretions (such as erythromycin, amoxicillin and cefuroxime).

Analogs

Analogues of Lazolvan children's syrup are: Ambrohexal, Ambrobene, Ambroxol, Flavamed, Medox, Lazolvan Uno, Halixol, etc.

Terms and conditions of storage

Store for no more than 3 years out of the reach of children, at temperatures up to 25 ° C.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Lazolvan children's syrup

Reviews about Lazolvan syrup for children are mainly left by parents who used the drug to treat cough in their children. They mark the speed of action and effectiveness of a given drug.

In some cases, side effects of ambroxol are mentioned, most often diarrhea and skin allergic reactions.

Price for Lazolvan syrup for children in pharmacies

The price of Lazolvan children's syrup in the pharmacy network is on average 170–250 rubles per 100 ml bottle.