Pyridoxine hydrochloride
Pyridoxine hydrochloride: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Pyridoxini hydrochloridum
ATX code: A11HA02
Active ingredient: Pyridoxine (Pyridoxine)
Producer: Ozone, LLC (Russia), Borisov plant of medical preparations, JSC (JSC "BZMP") (Republic of Belarus)
Description and photo update: 2018-24-10
Prices in pharmacies: from 34 rubles.
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Pyridoxine hydrochloride is a drug that replenishes vitamin B 6 deficiency.
Release form and composition
Dosage forms of Pyridoxine hydrochloride release:
- tablets: flat-cylindrical, from almost white to white, on one side of the risk, on both sides chamfer (in polymer containers of 10, 20, 30, 40, 50 or 100 pcs., in a cardboard box 1 container; in blisters of 10 or 50 pcs., in a cardboard box 1–5 or 10 packages);
- solution for injection 5%: transparent, colorless or somewhat yellowish (in ampoules of 1 ml, in a cardboard box of 10 ampoules).
Composition of 1 tablet:
- active substance: pyridoxine hydrochloride - 10 mg;
- auxiliary components: talc - 1 mg; colloidal silicon dioxide - 0.5 mg; calcium stearate - 1 mg; dextrose monohydrate (glucose) - 77.5 mg; microcrystalline cellulose - 10 mg.
Composition of 1 ml solution:
- active substance: pyridoxine hydrochloride - 50 mg;
- auxiliary component: water for injection - up to 1 ml.
Pharmacological properties
Pharmacodynamics
Vitamin B 6 (pyridoxine) takes part in the metabolism; it is important for the functioning of the central and peripheral nervous system.
It is part of the enzymes that transaminate and decarboxylate amino acids. When it enters the body, pyridoxine is phosphorylated, turning into pyridoxal-5-phosphate. It takes part in the metabolism of cysteine, methionine, tryptophan, glutamic and other amino acids, and also plays an important role in the metabolism of histamine. Promotes the normalization of lipid metabolism, increases diuresis and enhances the effect of diuretics.
An isolated deficiency of pyridoxine is observed in very rare cases, mainly in children who are on special artificial nutrition. It manifests itself in the form of diarrhea, seizures, anemia, and the development of peripheral neuropathy is also possible.
Pharmacokinetics
Pyridoxine is rapidly absorbed throughout the small intestine, more of it is absorbed in the jejunum.
Metabolism occurs in the liver with the formation of two pharmacologically active metabolites - pyridoxamine phosphate and pyridoxal phosphate. Pyridoxal phosphate binds to plasma proteins by 90%. Penetrates well into all tissues; accumulates mainly in the liver, to a lesser extent in the central nervous system and muscles.
It crosses the placenta and is secreted in breast milk. T 1/2 (half-life) ranges from 15 to 20 days. It is excreted by the kidneys, as well as during hemodialysis.
Indications for use
- a- and hypovitaminosis B 6 (therapy and prevention) associated with malnutrition, long-term infections and stress conditions, diarrhea, enteritis, malabsorption syndrome, conditions after removal of large areas of the intestine and stomach, hemodialysis;
- exudative diathesis, dermatitis (including seborrheic and atopic), psoriasis, herpetic infections (Herpes simplex, Varicella zoster) (simultaneously with other drugs);
- microcytic / hypochromic anemia, neuritis (including against the background of diabetes mellitus), congenital pyridoxine-dependent convulsive syndrome in newborns, sciatica, parkinsonism, Little's disease, Meniere's syndrome and disease, neuralgia, prevention of seizures in patients while taking ftivazide, alcoholism, gestosis, lesions liver while taking ethanol and drugs with anti-tuberculosis action, hepatitis in acute and chronic course, the need to increase urine output and enhance the action of diuretics (simultaneously with other drugs).
Contraindications
Absolute:
- age up to 18 years (tablets);
- pregnancy and breastfeeding period (tablets);
- individual intolerance to any of the components of the drug.
Relative (Pyridoxine hydrochloride is prescribed under medical supervision):
- peptic ulcer of the stomach and duodenum (associated with a likely increase in the acidity of gastric juice);
- cardiac ischemia;
- severe liver damage (tablets).
Instructions for the use of Pyridoxine hydrochloride: method and dosage
Pills
Pyridoxine hydrochloride is taken orally, preferably after meals.
For the prevention of B 6 -hypovitaminosis, the drug is used in a daily dose of 5 mg. For therapeutic purposes, it is usually prescribed 1–2 times a day, 20–30 mg for a course of 1–2 months.
Against the background of the use of isoniazid, ftivazid or other derivatives of isonicotinic acid hydrazide, it is advisable to prescribe pyridoxine at 5-10 mg per day for prophylaxis (in order to prevent dysfunctions of the central nervous system).
With sideroblastic anemia, Pyridoxine hydrochloride is taken daily at 100 mg (more expediently with riboflavin, cyanocobalamin and folic acid).
Injection
Pyridoxine hydrochloride in this dosage form is used in cases where oral administration is not possible / impractical (in case of vomiting / intestinal absorption disorders).
Route of administration: subcutaneously (subcutaneously), intramuscularly (intramuscularly), intravenously (intravenously).
For adults, the drug is usually prescribed in a daily dose of 50-100 mg in 1-2 doses, for children - 20 mg. The duration of use in adults is 1 month, in children - 2 weeks. With concomitant therapy with ftivazid, isoniazid, the drug should be used at 5-10 mg per day.
The use of Pyridoxine hydrochloride for other indications:
- sideroblastic anemia: i / m 2 times a week, 100 mg (advisable in combination with folic acid, cyanocobalamin, riboflavin);
- parkinsonism: intramuscularly, 100 mg per day, the course is 20–25 injections, repeated after 2–3 months. It is also possible to use another scheme - at the beginning of therapy, Pyridoxine hydrochloride is prescribed daily at 50-100 mg per day, then the daily dose is increased by 50 mg to reach 300-400 mg per day (in the form of a single injection for 12-15 days);
- depression of involutional age: i / m, 200 mg per day;
- pyridoxine-dependent convulsive syndrome: intravenous or intramuscularly daily at 30–600 mg (adults) or 10–100 mg (children).
Side effects
Possible side reactions: decreased lactation (can be used as a therapeutic effect), hydrochloric acid hypersecretion, allergic reactions, numbness, the appearance of a feeling of compression in the extremities (manifested as a symptom of "stockings" and "gloves").
With the rapid introduction of the solution, in rare cases, convulsions may occur.
Overdose
There is no information.
special instructions
The need for vitamin B 6 is met by food (it is partially synthesized by the intestinal microflora).
Vitamin B 6 is found in animal and plant organs, especially vegetables, unrefined cereals, yeast, egg yolk, meat, milk, fish, cattle liver and cod.
The need for pyridoxine (per day):
- men: 2-2.5 mg;
- women: 2 mg; additionally during pregnancy - 0.3 mg, during lactation - 0.5 mg;
- children: 6-12 months - 0.5 mg; 1-1.5 years - 0.9 mg; 1.5-2 years - 1 mg; 3-4 years - 1.3 mg; 5-6 years - 1.4 mg; 7-10 years - 1.7 mg; 11-13 years old - 2 mg; 14-17 years old (girls / boys) - 1.9 / 2.2.
In patients with severe liver damage, large doses of Pyridoxine hydrochloride may impair liver function.
When determining urobilinogen using Ehrlich's reagent, the results may be distorted.
When treating tuberculosis with isonicotinic acid hydrazide and its derivatives, in order to prevent dysfunctions of the central nervous system, in addition to 1000 mg of administered isonicotinic acid hydrazide, 100 mg of pyridoxine is prescribed.
The tablets contain glucose, which must be taken into account in diabetes mellitus.
Application during pregnancy and lactation
According to the instructions, pyridoxine hydrochloride in the form of tablets is not prescribed to pregnant / lactating women.
Pediatric use
The drug in the form of tablets should not be taken by patients under the age of 18.
Drug interactions
Pyridoxine hydrochloride can be used in combination with cardiac glycosides (it increases the synthesis of contractile proteins in the myocardium), glutamic acid, as well as magnesium and potassium aspartate (asparkam).
Possible interactions:
- penicillamine, isonicotine hydrazide, cycloserine and oral contraceptives containing estrogen: weakening the action of pyridoxine;
- levodopa: weakening of its activity;
- diuretics: enhancing their action;
- isoniazid and other drugs with anti-tuberculosis action: prevention / reduction of their toxic manifestations, including liver damage.
Analogs
Pyridoxine hydrochloride analogs are: Pyridoxine, Pyridoxine-Vial, Pyridoxine bufus.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Pyridoxine hydrochloride
According to reviews, Pyridoxine Hydrochloride is an inexpensive and effective drug that replenishes vitamin B 6 deficiency. It is often used as part of combination therapy, in particular, leukopenia, atherosclerosis, diabetes mellitus, shingles, psoriasis, neurodermatitis, etc., which significantly accelerates the therapeutic effect.
During the application, there is an improvement in metabolism, an increase in nail growth and a decrease in hair loss. Of the shortcomings, they indicate the inconvenience of dividing the tablets (due to their small size) and the likelihood of developing allergic reactions.
Price for Pyridoxine hydrochloride in pharmacies
The approximate price for Pyridoxine hydrochloride (50 tablets / 10 ampoules per package) is 33/37 rubles.
Pyridoxine hydrochloride: prices in online pharmacies
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Drug name Price Pharmacy |
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Pyridoxine hydrochloride 10 mg tablets 50 pcs. 34 rbl. Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
