Nobazit
Nobazit: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Nobazit
ATX code: J05AX
Active ingredient: enisamia iodide (Enisamium iodide)
Manufacturer: JSC "Moskhimfarmpreparaty" them. N. A. Semashko "(Russia)
Description and photo update: 09.10.2019
Prices in pharmacies: from 319 rubles.
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Nobazit is an antiviral agent.
Release form and composition
Dosage forms of Nobazit:
- capsules: gelatinous hard, size No. 3 (125 mg) and No. 1 (250 mg), orange; the contents of the capsules are a powder of yellow or yellow with a green tint, on the main background there may be splashes of yellow, yellow with a green tint and white [10 pcs. in a blister strip made of polyvinyl chloride (PVC) film and aluminum foil, in a cardboard box 1, 2 or 3 packages; 20 pcs. in a can made of low-density polyethylene, in a cardboard box 1 can];
- film-coated tablets: biconvex, round, yellow; core in cross section from pale yellow to yellow or yellow with a green tinge (10 pcs. in a blister strip made of PVC film and aluminum foil, in a cardboard box 1 or 2 packages).
Each pack also contains instructions for the use of Nobazit.
One capsule contains:
- active substance: N-methyl-4-benzylcarbamidopyridinium iodide (enisamia iodide) (in terms of 100% anhydrous substance) - 125 or 250 mg;
- additional components: colloidal silicon dioxide (aerosil), lactose monohydrate (milk sugar), calcium stearate, talc;
- capsule shell: gelatin, sunset yellow dye, titanium dioxide.
One tablet contains:
- active substance: N-methyl-4-benzylcarbamidopyridinium iodide (enisamia iodide) (in terms of 100% anhydrous substance) - 125 or 250 mg;
- additional components of the tablet core: microcrystalline cellulose (Vivapur 101), lactose monohydrate (milk sugar), povidone (low molecular weight medical polyvinylpyrrolidone or Plasdon K-17), sucrose (refined sugar), crospovidone (Polyplasdone XL10), copovidone S630 (Plasdonovidone) calcium stearate, talc;
- film casing: Aquarius Prime BAN314047 Yellow [capryl / caprylate (caprylic / capric triglyceride), titanium dioxide, hypromellose, quinoline yellow dye, iron oxide yellow and red oxide].
Pharmacological properties
Pharmacodynamics
The active ingredient of Nobazit - enisamia iodide, a derivative of isonicotinic acid, provides the antiviral effect of the drug by inhibiting influenza viruses and other causative agents of acute respiratory viral infections (ARVI). Its effectiveness is based on the inhibitory effect directly on the process of passage of viruses through the cell membrane.
The drug demonstrates interferonogenic properties and leads to an increase in the plasma level of endogenous interferon (interferon alpha and interferon gamma) in the blood by 3-4 times.
Nobazit enhances the body's resistance to infections caused by viruses. Reduces the severity of acute clinical manifestations of viral intoxication, helps to reduce the duration of the disease.
Pharmacokinetics
When used orally, enisamia iodide is rapidly absorbed. It is found in blood plasma 2–2.5 hours after administration at maximum concentration (C max).
The active substance and its metabolites circulate for a long time in the bloodstream, the half-life (T 1/2) is 13.5-14 hours. These substances are biotransformed in the liver, after which they are quickly (T 1/2 is 2-3 hours) removed from the tissues …
The drug is excreted in the urine in the form of metabolites by 90–95%.
Indications for use
Nobazit is recommended for use in ARVI, including those caused by the influenza virus, both in monotherapy mode and as part of complex treatment.
Contraindications
- severe organic damage to the liver and / or kidneys;
- a history of allergic reactions (regardless of the nature of the allergen);
- glucose-galactose malabsorption, lactose intolerance, lactase deficiency (milk sugar is contained in the auxiliary components of tablets and capsules);
- age up to 18 years;
- pregnancy, lactation period;
- hypersensitivity to any of the constituents of Nobazit.
Nobazit, instructions for use: method and dosage
Nobazit capsules and tablets are taken orally, after meals. They should be swallowed whole without chewing.
It is recommended to take the drug 3 times a day for 0.5 g. The maximum single dose should not exceed 1 g, daily - 2 g.
The course of therapy is 5-7 days.
Antiviral treatment should be started when the first signs of the disease develop. If, 3 days after the start of the intake, there is no improvement in the condition or the symptoms of infection are aggravated, or new ones appear, you need to consult a doctor.
Nobazit should be taken only according to those indications, the way of use, and also in those doses that are given in the description.
Side effects
Possible side reactions from systems and organs when taking Nobazit:
- respiratory system: throat irritation, shortness of breath;
- immune system: itching, urticaria, skin rashes, angioedema and other hypersensitivity reactions;
- digestive system: staining the tongue yellow, bitter taste and dry mouth, swelling of the oral mucosa, hypersalivation, heartburn, bloating, nausea, abdominal pain, vomiting, diarrhea, heaviness in the right hypochondrium.
During the post-registration period, the following side effects were recorded in some cases: weakness, dizziness, headache, fluctuations in blood pressure.
Overdose
Symptoms of an overdose of Nobazit may include an aggravation of adverse reactions.
In this condition, gastric lavage and symptomatic treatment are prescribed.
special instructions
Patients suffering from thyroid diseases, especially hyperthyroidism, should use Nobazit with caution.
Influence on the ability to drive vehicles and complex mechanisms
Nobazit does not adversely affect the ability to drive vehicles and various complex mechanisms.
Application during pregnancy and lactation
Pregnant and lactating women are contraindicated in the use of Nobazit.
Pediatric use
Patients under 18 years of age are not prescribed drug therapy.
With impaired renal function
Nobazit capsules and tablets are contraindicated in persons with severe organic kidney damage.
For violations of liver function
Reception of Nobazit is contraindicated in persons with severe organic liver damage.
Drug interactions
The interaction of enisamium iodide with other drugs / agents has not been sufficiently studied.
The combined use of this antiviral agent with ascorbic acid and other vitamins is advisable.
Treatment with the drug can be carried out simultaneously with the use of recombinant interferon.
With the combined use of the drug with immunomodulatory and antibacterial agents, an increase in the effect of the latter is noted.
If the patient receives the above or other medicines, including over-the-counter medicines, then it is recommended to consult a specialist before taking Nobazit.
Analogs
Analogues of Nobazit are Amizon, Arbidol, Aflyudol, Influcein, Kagocel, Nomides, Orvirem, Oseltamivir, Remantadin, Rimantadin, Seltavir, Umifenovir, etc.
Terms and conditions of storage
Store in a place protected from light and moisture, out of reach of children, at a temperature of 2-25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Nobazit
According to most of the reviews about Nobazit found on specialized sites, it is an affordable and fast-acting antiviral agent. The drug effectively eliminates ARVI symptoms within three days of administration, significantly improves the patient's condition and helps to reduce the duration of the disease. However, some patients consider the drug insufficiently effective, or even indicate the absence of any positive results after using it.
In some cases, users express dissatisfaction with the need to take two tablets / capsules at a time, which causes some inconvenience and requires the purchase of several packages, thereby increasing the cost of treatment.
The price of Nobazit in pharmacies
Depending on the form of release and packaging, the price for Nobazit can be:
- film-coated tablets (250 mg): 10 pcs. in a package - 290-340 rubles, for 20 pcs. in the package - 370-420 rubles;
- capsules (250 mg): 10 pcs. in the package - 300-330 rubles.
Nobazit: prices in online pharmacies
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Drug name Price Pharmacy |
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Nobazit 250 mg film-coated tablets 10 pcs. RUB 319 Buy |
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Nobazit 250 mg film-coated tablets 20 pcs. 392 RUB Buy |
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Nobazit tablets p.p. 250mg 20 pcs. 427 r Buy |
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Nobazit 250 mg capsules 10 pcs. RUB 516 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
