Riboxin Avexima
Riboxin Avexima: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Riboxin Avexima
ATX code: C01EB
Active ingredient: inosine (Inosine)
Producer: LLC "Avexima Siberia" (Russia)
Description and photo updated: 2019-11-12
Prices in pharmacies: from 63 rubles.
Buy
Riboxin Avexima is a metabolic agent.
Release form and composition
Dosage form - film-coated tablets: round, biconvex, from light yellow to yellow-orange; the cross section shows two layers (outer - the color of the shell, inner - white) (in a cardboard box 1 glass or polymer jar containing 50 tablets, or from 1 to 10 blisters of 10 tablets and instructions for use of Riboxin Avexim).
Composition of 1 film-coated tablet:
- active substance: inosine - 200 mg (in terms of 100% substance);
- auxiliary components: water-soluble methylcellulose, sucrose, stearic acid, potato starch;
- film shell: beeswax, polysorbate 80, Tropeolin O (resorcinol yellow), titanium dioxide, water-soluble methylcellulose.
Pharmacological properties
Pharmacodynamics
As an active substance, Riboxin Avexima contains inosine, a drug that regulates metabolic processes, and has antiarrhythmic and antihypoxic effects. It is a precursor of the synthesis of purine nucleotides: guanosine triphosphate (GTP) and adenosine triphosphate (ATP). Takes a direct part in the metabolism of glucose, activates this metabolism in patients with hypoxia and ATP deficiency. Prevents the development of complications after intraoperative renal ischemia. Under the action of inosine, the coronary circulation improves, the energy balance of the myocardium increases.
Penetrating into cells, inosine improves metabolic processes in the heart muscle, promotes better relaxation of the myocardium in diastole, increases the strength of heart contractions, increases the energy level - all this leads to an increase in the stroke volume of blood.
The drug activates the metabolism of pyruvic acid, which contributes to the normal process of tissue respiration. Participates in the activation of xanthine dehydrogenase. Stimulates the activity of some enzymes of the Krebs cycles and the synthesis of nucleotides. Activates the regeneration of tissues, especially the myocardium and the mucous membrane of the gastrointestinal tract. Reduces platelet aggregation.
Pharmacokinetics
Once in the gastrointestinal tract after ingestion, inosine is well absorbed. The process of metabolism undergoes in the liver, as a result glucuronic acid is formed, which is subsequently oxidized.
It is excreted in small quantities by the kidneys.
Indications for use
Riboxin Avexim is prescribed as part of the complex treatment of coronary heart disease, cardiac arrhythmias and the consequences of myocardial infarction caused by the intake of cardiac glycosides.
Contraindications
Absolute:
- intolerance to fructose;
- deficiency of sucrase / isomaltase;
- galactose / glucose malabsorption syndrome;
- hyperuricemia;
- gout;
- pregnancy;
- lactation period;
- childhood;
- hypersensitivity to the components of Riboxin Avexim tablets.
Caution should be observed when prescribing the drug to patients with diabetes mellitus and renal failure.
Riboxin Avexima, instructions for use: method and dosage
Riboxin Avexim tablets should be taken orally before meals.
The average daily dose can vary from 600 to 2400 mg (3–12 tablets).
The recommended starting dose is 600-800 mg, 200 mg (1 tablet) 3 or 4 times a day. If the drug is well tolerated, after 2-3 days the dose is increased to 1200 mg - 400 mg (2 tablets) 3 times a day. If necessary, it is increased to a maximum of 2400 mg (12 tablets) per day.
For patients with urocoproporphyria, Riboxin Avexim is prescribed 200 mg 4 times.
The duration of taking the drug is determined individually and can be 4-12 weeks.
Side effects
Riboxin Avexima in patients with individual intolerance causes allergic reactions, manifested by itching, skin flushing and urticaria.
With prolonged use of the drug in rare cases, there is an increase in the concentration of uric acid in the blood, with gout - its aggravation.
Overdose
There have been no reports of an overdose of Riboxin Avexim.
special instructions
Due to the likelihood of an increase in the concentration of uric acid in urine and blood, these indicators should be checked periodically during treatment.
Patients with diabetes mellitus should take into account that 1 tablet contains carbohydrates in the amount of 0.00641 bread units.
Influence on the ability to drive vehicles and complex mechanisms
There is no data that would indicate a negative effect of Riboxin Avexim on the ability to drive complex mechanisms and vehicles.
Application during pregnancy and lactation
The safety of taking inosine during pregnancy and lactation has not been established. Riboxin Avexim is contraindicated for women while carrying a child. If a course of treatment is required during lactation, breastfeeding should be discontinued.
Pediatric use
Riboxin Avexim is prescribed only for adults.
With impaired renal function
In case of renal failure, the use of the drug is possible, however, it is required to observe precautions.
Drug interactions
The effectiveness of inosine decreases with the simultaneous administration of immunosuppressants (including thymodepressin, antilympholine, azathioprine, cyclosporine).
Analogs
Analogues of Riboxin Avexim are Inosine, Inosie-F, Riboxin, Riboxin-Vial, Riboxin bufus, Riboxin-Ferein, Riboxin-LekT.
Terms and conditions of storage
Store out of the reach of children and in a dry place protected from light at temperatures up to 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Riboxin Avexim
Most of the reviews about Avexim's Riboxin are positive. The drug is well tolerated, practically does not cause side effects. It has a beneficial effect on the myocardium, and also promotes the regeneration of the mucous membrane of the gastrointestinal tract in destructive diseases, has a positive effect on metabolic processes in the kidneys and other organs.
Despite the fact that the drug is contraindicated in pregnancy due to the lack of data confirming its safety during this period, doctors sometimes recommend inosine to pregnant women, since it enhances tissue trophism and improves the adaptive abilities of the body, which contributes to an easier pregnancy.
Negative reviews about inosine were once left by athletes and bodybuilders who took the drug in order to improve physical performance and gain mass. However, it has long been proven that the drug does not have an anabolic effect on muscle mass.
Price for Riboxin Avexima in pharmacies
The price of Riboxin Avexima in the form of film-coated tablets is from 67 rubles. per package containing 50 pcs.
Riboxin Avexima: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Riboxin Avexima 200 mg film-coated tablets 50 pcs. RUB 63 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
