Dioctahedral Smectite

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Dioctahedral smectite: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. Drug interactions
12. Analogs
13. Terms and conditions of storage
14. Terms of dispensing from pharmacies
15. Reviews
16. Price in pharmacies

Latin name: Smectit dioctaedric

ATX code: A07BC05

Active ingredient: dioctahedral smectite (Smectite dioctaedric)

Producer: LLC "Biofarmkombinat" (Russia); LLC "YuzhFarm" (Russia)

Description and photo update: 2019-25-12

Dioctahedral smectite is an antidiarrheal agent.

Release form and composition

The drug is produced in the form of a powder for preparation of a suspension for oral administration (with orange, vanilla or caramel flavor): from pale yellow / grayish white to grayish white / brownish white or brownish gray with a yellow tint, with a weak odor nonspecific to a low orange, vanilla or low caramel odor (depending on the filling) (3.76 g each in a sachet made of a combined multilayer material, in a cardboard box 1, 3, 5, 10, 15, 20, 30 or 250 sachets and instructions for use of dioctahedral Smectite; it is possible to apply the text of the instruction on the secondary packaging if it contains 30 sachets).

Contents of 1 sachet includes:

active substance: dioctahedral smectite - 3 g;
additional components: sodium saccharinate / sodium saccharinate dihydrate, dextrose monohydrate, vanillin / orange flavor / caramel flavor.

Pharmacological properties

Pharmacodynamics

The drug is of natural origin and has an adsorbing effect. The drug regulates the barrier function of the gastrointestinal tract (GIT) mucosa, creates polyvalent bonds with the glycoproteins of the cavity mucus, increases its amount, enhances the cytoprotective effect (against the negative effects of bile salts, hydrochloric acid, microorganisms and their toxins). Dioctahedral smectite is characterized by selective sorption properties, which are due to its discoid crystal structure; it absorbs viruses, bacteria and toxins localized in the lumen of the gastrointestinal tract.

When used in therapeutic doses, the active substance does not affect intestinal motility. It is X-ray transparent, does not stain the stool.

Pharmacokinetics

Dioctahedral smectite is not absorbed in the gastrointestinal tract, including in the presence of diseases of the latter, accompanied by manifestations of colitis and colonopathy. It is excreted unchanged.

Indications for use

chronic and acute diarrhea of drug and allergic genesis, as well as against the background of violations of the qualitative composition of food and diet; diarrhea of infectious genesis (as part of complex treatment);
heartburn, bloating, discomfort, feeling of heaviness in the abdomen, other symptoms of dyspepsia caused by diseases of the gastrointestinal tract.

Contraindications

Absolute:

intestinal obstruction;
glucose-galactose malabsorption, fructose intolerance, sucrase / isomaltase deficiency (depending on the manufacturer);
hypersensitivity to any constituent of Smectite dioctahedral powder.

Relative contraindications for which the sorbent should be taken with caution are severe chronic constipation and diabetes mellitus (due to the dextrose present in the composition).

Dioctahedral smectite, instructions for use: method and dosage

A suspension prepared from dioctahedral Smectite powder is taken orally.

In case of esophagitis, the drug should be taken after meals, for other indications - between meals. A single dose for children and adults is the contents of 1 sachet.

Recommended frequency of admission for the treatment of acute diarrhea:

adults and adolescents over 12 years old: 6 times a day;
children 1–12 years old: 4 times a day for 3 days, then 2 times a day;
infants under 1 year old: 2 times a day for 3 days, then 1 time a day.

Frequency rate of reception of dioctahedral Smectite for other indications:

adults and adolescents over 12 years old: 3 times a day:
children 2-12 years old: 2-3 times a day;
children 1–2 years old: 1–2 times a day;
infants under 1 year: once a day.

The recommended duration of treatment is 3–7 days.

Adults and adolescents over 12 years old need to dissolve the contents of 1 sachet in 100 ml of water, gradually adding the powder and stirring gently. For children under 12 years old, the contents of 1 sachet should be dissolved in 50 ml of liquid or mixed with any semi-liquid product, such as puree, porridge, baby food. If necessary, you can distribute the daily dose over several doses throughout the day.

Unused prepared suspension should be placed in a closed container and stored in the refrigerator for no more than 16 hours at a temperature of 2-8 ° C. Shake it vigorously before each use.

Side effects

In the course of clinical studies of the drug, the following adverse events were recorded in both children and adults:

often: constipation; usually eliminated by dose reduction, but rarely required discontinuation of treatment;
infrequently: vomiting, flatulence.

These adverse reactions were generally minor and transient.

In the process of post-registration use of dioctahedral Smectite, cases of hypersensitivity reactions (at an unknown frequency) were noted, including urticaria, itching, rash and angioedema. There have been reports of episodes of exacerbation of constipation.

Overdose

When using the drug in excessively high doses, severe constipation or bezoar may develop.

special instructions

For children in the treatment of acute diarrhea, and, if necessary, for adults, drug therapy should be carried out in conjunction with rehydration measures.

A set of measures for replenishing the volume of fluid is prescribed taking into account the age and characteristics of the patient, as well as the severity of the course of the disease.

Influence on the ability to drive vehicles and complex mechanisms

There is no information.

Application during pregnancy and lactation

Dioctahedral smectite can be used by pregnant and lactating women, without the need to change the dose and regimen.

Pediatric use

The suspension can be used in children of any age according to indications according to the dosage regimen.

Drug interactions

Dioctahedral smectite is able to reduce the rate and degree of absorption of drugs used simultaneously with it, therefore, an interval of 1-2 hours must be observed between taking these drugs and the suspension.

Analogs

Analogs of dioctahedral Smectite are Diosmectite, Dioctab Solution Tablets, Neosmectin, Endosorb, Smecta, etc.

Terms and conditions of storage

Store in a place out of the reach of children, protected from light, at a temperature not exceeding 25 ° C.

The shelf life (depending on the manufacturer) is 3 or 4 years.

Terms of dispensing from pharmacies

Available without a prescription.

Reviews about Smectite dioctahedral

On specialized sites, there are currently no reviews about Smectite dioctahedral, according to which it would be possible to objectively assess the effectiveness and disadvantages of the natural enterosorbent of these manufacturers.

Price for Smectite dioctahedral in pharmacies

There is no reliable information on the price of dioctahedral Smectite, since it is currently not available in the pharmacy chain. The cost of its analogue, Diosmectite, in the form of a powder for preparing a suspension (3 g in a sachet), can be for 10 pcs. in the package - 120 rubles, for 30 pcs. in the package - 267 rubles.

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!