Combilipen tabs
Combilipen tabs: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Combilipen tabs
ATX code: A11DB
Active ingredient: benfotiamine (benfotiamine), cyanocobalamin (cyanocobalamin), pyridoxine (pyridoxine)
Producer: Pharmstandard-UfaVITA, JSC (Russia)
Description and photo update: 2018-24-10
Prices in pharmacies: from 229 rubles.
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Kombilipen tabs is a combined multivitamin preparation that replenishes the deficiency of B vitamins.
Release form and composition
Dosage form - film-coated tablets: round, biconvex, almost white or white (in a blister strip of 15 pcs., In a cardboard box 1, 2, 3 or 4 packages).
Composition of 1 tablet:
- active substances: benfotiamine (vitamin B 1) - 100 mg, pyridoxine hydrochloride (vitamin B 6) - 100 mg, cyanocobalamin (vitamin B 12) - 0.002 mg;
- auxiliary components (core): povidone (polyvinylpyrrolidone, povidone K-30), sodium carmellose, microcrystalline cellulose, calcium stearate, talc, sucrose (granulated sugar), polysorbate 80;
- shell: macrogol (polyethylene oxide-4000, macrogol-4000), hypromellose (hydroxypropyl methylcellulose), povidone (low molecular weight polyvinylpyrrolidone, povidone K-17), talc, titanium dioxide.
Pharmacological properties
Pharmacodynamics
Combilipen tabs is a multivitamin complex. The properties of its constituent vitamins determine the pharmacological action of the drug.
Benfotiamine is a fat-soluble analogue of vitamin B 1 (thiamine). Takes part in metabolism, affects the conduction of nerve impulses.
Pyridoxine hydrochloride is a form of vitamin B 6. It stimulates the metabolism of proteins, fats and carbohydrates, takes part in the production of blood cells and hemoglobin. Pyridoxine contributes to the normal functioning of the central and peripheral nervous system, participating in the processes of synaptic transmission, excitation, inhibition, transport of sphingosine - a component of the nervous membrane, as well as in the production of catecholamines.
Cyanocobalamin - vitamin B 12, takes part in the synthesis of nucleotides, thus influencing intracellular processes. Promotes the formation of choline, and later on - acetylcholine, which is an important transmitter of nerve impulses. Vitamin B 12 is an important component for normal blood formation, growth, and development of epithelial tissue. It is involved in the metabolism of folic acid, the synthesis of myelin (the main component of the nervous membrane).
Pharmacokinetics
Pharmacokinetic information not provided.
Indications for use
According to the instructions, Kombilipen Tabs is indicated for use in the complex treatment of the following neurological diseases:
- inflammation of the facial nerve;
- trigeminal neuralgia;
- polyneuropathy of various origins (including diabetic, alcoholic);
- pain syndrome in patients with diseases of the spine (lumboischialgia, intercostal neuralgia, lumbar, cervical, cervicobrachial syndrome, radiculopathy, degenerative changes in the spine).
Contraindications
- severe / acute decompensated heart failure;
- childhood;
- pregnancy and lactation;
- individual hypersensitivity to any components of the drug.
Instructions for use of Kombilipen tabs: method and dosage
The tablets are taken orally, swallowed whole and washed down with a small amount of liquid after meals.
The recommended dosage is 1 tablet 1-3 times a day. The duration of the course should be agreed with the attending physician.
The duration of therapy with high doses of the drug should not exceed 4 weeks.
Side effects
Allergic reactions (urticaria, pruritus, edema, anaphylactic shock) may occur when taking Combilipen Tabs.
In some cases, the appearance of tachycardia, hyperhidrosis, nausea, acne is possible.
Overdose
In case of an overdose of Kombilipen tabs, the symptoms of side effects of the drug may increase: allergic reactions, nausea, vomiting, tachycardia, dizziness.
Treatment for intoxication consists in gastric lavage, intake of activated charcoal and symptomatic therapy.
special instructions
It is not recommended to take other multivitamin preparations containing B vitamins during Kombilipen Tabs therapy.
The use of alcoholic beverages simultaneously with drug treatment is extremely undesirable, since the absorption of thiamine in such cases is sharply reduced.
Application during pregnancy and lactation
The drug is not recommended to be taken during pregnancy and breastfeeding, as it contains a significant dose of vitamin B 6 (100 mg).
Pediatric use
It is contraindicated to prescribe Combilipen Tabs to pediatric patients.
Drug interactions
- heavy metal salts: incompatibility with vitamin B 12;
- levodopa: reducing the effect of therapeutic doses of vitamin B 6;
- ethanol: a sharp decrease in the absorption of vitamin B 1.
Analogs
Analogs of Kombilipen tabs are: Unigamma, Milgamma compositum, Neuromultivit, Pentovit.
Terms and conditions of storage
Store at a temperature not exceeding 25 ° C, out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Kombilipene tabs
Judging by the reviews about Kombilipene tabs, the drug has an effective effect on pain in the neck, back, osteochondrosis and neuralgia of the facial nerve. However, the analgesic effect does not occur immediately, but after several days of taking the tablets according to the recommended dosage regimen.
Side effects during treatment with the drug, judging by the reviews of patients, practically do not appear.
In addition, users note the affordable cost of Kombilipen tabs.
The price of Combilipen tabs in pharmacies
The price for Kombilipen tabs is approximately: 30 tablets - 142–242 rubles; 60 tablets - 230–383 rubles.
Combilipen tabs: prices in online pharmacies
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Drug name Price Pharmacy |
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Kombilipen tabs film-coated tablets 30 pcs. 229 r Buy |
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Combilipen Tabs tablets p.o. 30 pcs. 289 r Buy |
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Kombilipen tabs film-coated tablets 60 pcs. 399 RUB Buy |
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Combilipen Tabs tablets p.o. 60 pcs. 494 r Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
