Combilipen Tabs

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Combilipen tabs: instructions for use and reviews

1. Release form and composition
2. Pharmacological properties
3. Indications for use
4. Contraindications
5. Method of application and dosage
6. Side effects
7. Overdose
8. Special instructions
9. Application during pregnancy and lactation
10. Use in childhood
11. Drug interactions
12. Analogs
13. Terms and conditions of storage
14. Terms of dispensing from pharmacies
15. Reviews
16. Price in pharmacies

Latin name: Combilipen tabs

ATX code: A11DB

Active ingredient: benfotiamine (benfotiamine), cyanocobalamin (cyanocobalamin), pyridoxine (pyridoxine)

Producer: Pharmstandard-UfaVITA, JSC (Russia)

Description and photo update: 2018-24-10

Prices in pharmacies: from 229 rubles.

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Kombilipen tabs is a combined multivitamin preparation that replenishes the deficiency of B vitamins.

Release form and composition

Dosage form - film-coated tablets: round, biconvex, almost white or white (in a blister strip of 15 pcs., In a cardboard box 1, 2, 3 or 4 packages).

Composition of 1 tablet:

active substances: benfotiamine (vitamin B ₁) - 100 mg, pyridoxine hydrochloride (vitamin B ₆) - 100 mg, cyanocobalamin (vitamin B ₁₂) - 0.002 mg;
auxiliary components (core): povidone (polyvinylpyrrolidone, povidone K-30), sodium carmellose, microcrystalline cellulose, calcium stearate, talc, sucrose (granulated sugar), polysorbate 80;
shell: macrogol (polyethylene oxide-4000, macrogol-4000), hypromellose (hydroxypropyl methylcellulose), povidone (low molecular weight polyvinylpyrrolidone, povidone K-17), talc, titanium dioxide.

Pharmacological properties

Pharmacodynamics

Combilipen tabs is a multivitamin complex. The properties of its constituent vitamins determine the pharmacological action of the drug.

Benfotiamine is a fat-soluble analogue of vitamin B ₁ (thiamine). Takes part in metabolism, affects the conduction of nerve impulses.

Pyridoxine hydrochloride is a form of vitamin B ₆. It stimulates the metabolism of proteins, fats and carbohydrates, takes part in the production of blood cells and hemoglobin. Pyridoxine contributes to the normal functioning of the central and peripheral nervous system, participating in the processes of synaptic transmission, excitation, inhibition, transport of sphingosine - a component of the nervous membrane, as well as in the production of catecholamines.

Cyanocobalamin - vitamin B ₁₂, takes part in the synthesis of nucleotides, thus influencing intracellular processes. Promotes the formation of choline, and later on - acetylcholine, which is an important transmitter of nerve impulses. Vitamin B ₁₂ is an important component for normal blood formation, growth, and development of epithelial tissue. It is involved in the metabolism of folic acid, the synthesis of myelin (the main component of the nervous membrane).

Pharmacokinetics

Pharmacokinetic information not provided.

Indications for use

According to the instructions, Kombilipen Tabs is indicated for use in the complex treatment of the following neurological diseases:

inflammation of the facial nerve;
trigeminal neuralgia;
polyneuropathy of various origins (including diabetic, alcoholic);
pain syndrome in patients with diseases of the spine (lumboischialgia, intercostal neuralgia, lumbar, cervical, cervicobrachial syndrome, radiculopathy, degenerative changes in the spine).

Contraindications

severe / acute decompensated heart failure;
childhood;
pregnancy and lactation;
individual hypersensitivity to any components of the drug.

Instructions for use of Kombilipen tabs: method and dosage

The tablets are taken orally, swallowed whole and washed down with a small amount of liquid after meals.

The recommended dosage is 1 tablet 1-3 times a day. The duration of the course should be agreed with the attending physician.

The duration of therapy with high doses of the drug should not exceed 4 weeks.

Side effects

Allergic reactions (urticaria, pruritus, edema, anaphylactic shock) may occur when taking Combilipen Tabs.

In some cases, the appearance of tachycardia, hyperhidrosis, nausea, acne is possible.

Overdose

In case of an overdose of Kombilipen tabs, the symptoms of side effects of the drug may increase: allergic reactions, nausea, vomiting, tachycardia, dizziness.

Treatment for intoxication consists in gastric lavage, intake of activated charcoal and symptomatic therapy.

special instructions

It is not recommended to take other multivitamin preparations containing B vitamins during Kombilipen Tabs therapy.

The use of alcoholic beverages simultaneously with drug treatment is extremely undesirable, since the absorption of thiamine in such cases is sharply reduced.

Application during pregnancy and lactation

The drug is not recommended to be taken during pregnancy and breastfeeding, as it contains a significant dose of vitamin B ₆ (100 mg).

Pediatric use

It is contraindicated to prescribe Combilipen Tabs to pediatric patients.

Drug interactions

heavy metal salts: incompatibility with vitamin B ₁₂;
levodopa: reducing the effect of therapeutic doses of vitamin B ₆;
ethanol: a sharp decrease in the absorption of vitamin B ₁.

Analogs

Analogs of Kombilipen tabs are: Unigamma, Milgamma compositum, Neuromultivit, Pentovit.

Terms and conditions of storage

Store at a temperature not exceeding 25 ° C, out of the reach of children.

Shelf life is 2 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Kombilipene tabs

Judging by the reviews about Kombilipene tabs, the drug has an effective effect on pain in the neck, back, osteochondrosis and neuralgia of the facial nerve. However, the analgesic effect does not occur immediately, but after several days of taking the tablets according to the recommended dosage regimen.

Side effects during treatment with the drug, judging by the reviews of patients, practically do not appear.

In addition, users note the affordable cost of Kombilipen tabs.

The price of Combilipen tabs in pharmacies

The price for Kombilipen tabs is approximately: 30 tablets - 142–242 rubles; 60 tablets - 230–383 rubles.

Combilipen tabs: prices in online pharmacies

Drug name

Price

Pharmacy

Kombilipen tabs film-coated tablets 30 pcs.

229 r

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Combilipen Tabs tablets p.o. 30 pcs.

289 r

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Kombilipen tabs film-coated tablets 60 pcs.

399 RUB

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Combilipen Tabs tablets p.o. 60 pcs.

494 r

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Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!