Bromhexine 8 Berlin-Chemie
Bromhexin 8 Berlin-Chemie: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Instructions for the use of Bromhexine 8 Berlin-Chemie: method and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews Bromhexine 8 Berlin-Chemie
- 18. Price in pharmacies
Latin name: Bromhexine 8 Berlin-Chemie
ATX code: R05CB02
Active ingredient: Bromhexine (Bromhexine)
Producer: Berlin-Chemie AG / Menarini Group (Germany)
Description and photo update: 2018-22-10
Prices in pharmacies: from 104 rubles.
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Bromhexine 8 Berlin-Chemie is a mucolytic and expectorant drug.
Release form and composition
The dosage form of Bromhexine 8 Berlin-Chemie - dragees: from greenish-yellow to yellow, biconvex, the core is almost white (20 or 25 pieces in blisters, 1 or 2 blisters are placed in a cardboard box).
Composition of 1 dragee:
- active substance: bromhexine hydrochloride - 8 mg;
- auxiliary components: lactose monohydrate - 34.4 mg; magnesium stearate - 0.6 mg; corn starch - 14.6 mg; gelatin - 1.8 mg; colloidal silicon dioxide - 0.6 mg;
- shell: sucrose - 27.704 mg; calcium carbonate - 4.326 mg; macrogol 6000 - 1.75 mg; glucose syrup - 1.639 mg; magnesium carbonate - 1.507 mg; talc - 1.507 mg; titanium dioxide (E 171) - 1.166 mg; povidone K-25 - 0.243 mg; quinoline yellow (E 104) - 0.146 mg; carnauba wax - 0.012 mg.
Pharmacological properties
Pharmacodynamics
Bromhexine has an expectorant and mucolytic effect.
It activates the ciliated epithelium, reduces the viscosity of sputum, helps to increase the volume of sputum and improve its discharge, and also stimulates the production of endogenous surfactant, which, during respiration, ensures the stability of alveolar cells.
The therapeutic effect develops after 2–5 days from the start of admission.
Pharmacokinetics
When taken orally, 99% of bromhexine is absorbed from the gastrointestinal tract within 30 minutes, the connection with blood plasma proteins is 99%.
Bromhexine crosses the blood-brain and placental barriers and into breast milk.
It undergoes oxidation and demethylation in the liver, metabolized to ambroxol. In severe liver disease, there is a decrease in the clearance of bromhexine.
The half-life is 15 hours (this is due to slow reverse diffusion from tissues). It is excreted in the form of metabolites by the kidneys.
In patients with chronic renal failure, the excretion of metabolites is impaired.
Can cumulate with repeated use.
Indications for use
According to the instructions, Bromhexin 8 Berlin-Chemie is used for disorders of secretion and transport of sputum associated with acute / chronic bronchopulmonary diseases (tracheobronchitis, emphysema, acute and chronic bronchitis, etc.).
Contraindications
Absolute:
- exacerbation of gastric ulcer and duodenal ulcer;
- sucrose-isomaltase deficiency;
- intolerance to fructose or galactose, lactase deficiency, glucose-galactose malabsorption syndrome;
- I trimester of pregnancy;
- age up to 6 years;
- individual intolerance to the active or additional components of the drug.
Relative [diseases and (or) conditions in the presence of which caution is required when taking Bromhexine 8 Berlin-Chemie]:
- hepatic or renal failure;
- disorders of bronchial motility, proceeding with excessive accumulation of secretions;
- burdened history of a tendency to gastric bleeding.
Instructions for the use of Bromhexine 8 Berlin-Chemie: method and dosage
Bromhexine 8 Berlin-Chemie is taken orally with a sufficient amount of liquid, without chewing, preferably after meals.
The recommended single dose (with a frequency of administration 3 times a day):
- children 6-14 years old, as well as patients weighing up to 50 kg: 1 tablet;
- adults and adolescents from 14 years old: 1-2 tablets.
Patients with impaired renal / hepatic function need to reduce the frequency of administration or the size of the single dose (medical advice is required).
The duration of admission is determined by the indications. If you need to take the drug for more than 4-5 days, you need to consult a specialist.
Side effects
In most cases, Bromhexine 8 Berlin-Chemie is well tolerated by patients.
Possible adverse reactions (> 10% - very common;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01% - very rare):
- immune system: infrequently - hypersensitivity reactions (in the form of a skin rash, Quincke's edema, difficulty breathing, pruritus, urticaria); very rarely - anaphylactic reactions, up to anaphylactic shock;
- digestive system: infrequently - diarrhea, vomiting, nausea, abdominal pain;
- subcutaneous tissue and skin: very rarely - severe skin reactions, including Lyell and Stevens-Johnson syndromes;
- others: infrequently - fever.
In case of any allergic reactions, therapy should be interrupted and a doctor should be consulted.
Overdose
The life-threatening consequences of overdose are unknown.
Possible symptoms: dyspeptic disorders, nausea, diarrhea, vomiting.
Therapy: gastric lavage, artificial vomiting during the first 1-2 hours after taking the drug.
With forced diuresis or hemodialysis, elimination of bromhexine does not occur (associated with a high volume of distribution and a high degree of protein binding).
special instructions
In the course of therapy, it is recommended to drink sufficient liquid, as this increases the secretolytic effect of the drug.
Due to the presence of a risk of delayed discharge in the airways in case of impaired bronchial motility or a large volume of sputum secreted, taking Bromhexine 8 Berlin-Chemie requires caution.
In patients with severe renal insufficiency, the possibility of accumulation of metabolites formed in the liver should be considered. Monitoring of renal function is recommended during long-term therapy.
Influence on the ability to drive vehicles and complex mechanisms
While taking Bromhexine 8 Berlin-Chemie, you need to be careful when driving.
Application during pregnancy and lactation
The first trimester of pregnancy is a contraindication to taking the drug.
Pediatric use
Bromhexine 8 Berlin-Chemie is not prescribed for children under 6 years old.
With impaired renal function
Prescribing the drug for renal failure requires caution.
For violations of liver function
Prescribing the drug for liver failure requires caution.
Drug interactions
Bromhexine 8 Berlin-Chemie should not be used in combination with antitussive drugs (including those containing codeine), as this makes it difficult to evacuate liquefied sputum.
In the first 4–5 days of antimicrobial therapy, bromhexine promotes the penetration of cephalexin, erythromycin, ampicillin, oxytetracycline and other antibacterial drugs into the bronchial secretions.
Analogs
Bromhexine 8 Berlin-Chemie analogs are Bromhexine, Bromhexine Grindeks, Bromhexine 4 Berlin-Chemie, Bronchostop, Solvin, etc.
Terms and conditions of storage
Store at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 5 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Bromhexine 8 Berlin-Chemie
According to reviews, Bromhexine 8 Berlin-Chemie is an affordable and effective drug that promotes coughing up and sputum discharge. However, it is noted that in some cases, combination therapy may be required to completely eliminate symptoms. Also, the likelihood of developing side effects should not be ruled out.
Price for Bromhexine 8 Berlin-Chemie in pharmacies
The approximate price for Bromhexin 8 Berlin-Chemie (25 tablets per pack) is 93–120 rubles.
Bromhexine 8 Berlin-Chemie: prices in online pharmacies
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Drug name Price Pharmacy |
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Bromhexine 8 Berlin-Chemie 8 mg dragee 25 pcs. RUB 104 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
