Pancreatin forte
Pancreatin forte: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Pancreatin forte
ATX code: A09AA02
Active ingredient: pancreatin (Pancreatin)
Manufacturer: PJSC "Biosintez" (Russia)
Description and photo update: 2019-05-11
Prices in pharmacies: from 51 rubles.
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Pancreatin forte is a digestive enzyme preparation.
Release form and composition
The drug is produced in the form of enteric-coated tablets: brown or dark brown, round, biconvex, with a specific odor (20, 30 or 60 pcs. In dark polymer / glass jars, in a cardboard box 1 can; 10 pcs.. in blisters, in a cardboard box 2, 3 or 6 packages and instructions for the use of Pancreatin forte).
1 tablet contains:
- active substance: pancreatin with the following enzyme activity: amylase - not less than 4620 U (unit of action), lipase - not less than 3850 U, protease - 275-500 U;
- auxiliary components: sodium carboxymethyl starch (primogel), microcrystalline cellulose, pregelatinized starch (starch 1500), povidone (low molecular weight medical polyvinylpyrrolidone), colloidal silicon dioxide (aerosil), magnesium stearate;
- shell composition: tween-80 (polysorbate), cellacephate (acetylphthalylcellulose), vaseline oil (liquid paraffin), brown iron oxide (ferronate E172 or sikovit 70 E172).
Pharmacological properties
Pharmacodynamics
Pancreatin forte is a digestive enzyme preparation with proteolytic, amylolytic and lipolytic effects. Compensating for the insufficiency of the secretory function of the pancreas, it helps to improve the digestion of food. Pancreatic enzymes (lipase, trypsin, alpha-amylase, chymotrypsin) are involved in the biotransformation of fats to glycerol and fatty acids, proteins to amino acids, starch to dextrins and monosaccharides.
As a result of improving the breakdown of plant fiber, the hemicellulase enzyme helps to reduce the formation of gases in the intestine.
The analgesic effect of the drug is due to the suppression of stimulated secretion of the pancreas by trypsin.
Pharmacokinetics
After oral administration, the maximum activity of pancreatin is reached after 30–45 minutes.
The enteric coating protects pancreatic enzymes from the acidic environment of gastric juice, their release occurs in the alkaline environment of the small intestine.
Indications for use
- exocrine pancreatic insufficiency: dyspepsia, chronic pancreatitis, pancreatectomy, condition after radiation, cystic fibrosis - as replacement therapy;
- diarrhea of non-infectious genesis, flatulence;
- indigestion due to the condition after surgery for resection of the stomach and small intestine;
- gastrocardiac syndrome (Rehmeld syndrome);
- disorders of chewing function, sedentary lifestyle, prolonged immobilization, inaccuracies in nutrition (irregular nutrition, consumption of large quantities or fatty foods) in persons with normal function of the gastrointestinal tract (GIT) - in order to normalize food digestion;
- preparation for X-ray or ultrasound examination of the abdominal organs.
Contraindications
Absolute:
- acute pancreatitis;
- exacerbation of chronic pancreatitis;
- age up to three years;
- hypersensitivity to the components of the drug.
It is recommended to take Pancreatin forte with caution during pregnancy and lactation.
Pancreatin forte, instructions for use: method and dosage
Pancreatin forte tablets are taken orally, swallowing whole (without violating the integrity of the shell), during or immediately after a meal, washed down with a large amount of liquid, preferably alkaline (water, fruit juices).
The doctor sets the dose of the drug in terms of lipase individually, taking into account the degree of pancreatic insufficiency and the patient's age.
The duration of the course of treatment depends on the clinical indication. If the digestive process is disturbed due to errors in the diet, you can limit yourself to a single dose of the drug or a course of several days. With constant substitution therapy, reception can last from several months or more.
For adults, the average daily dose is 150,000 lipase units, with complete insufficiency of the exocrine function of the pancreas, it should correspond to the daily requirement of an adult for lipase - 400,000 units.
Recommended dosage of Pancreatin forte:
- adult patients: 3-4 tablets 3 times a day; during preparation for X-ray or ultrasound examination of the abdominal organs, take 2 tablets 2-3 times a day for 2-3 days before the study;
- children over three years old: 100,000 lipase units per day, divided into 3-4 doses.
The maximum daily dose of enzymes should not exceed 15,000–20,000 IU of lipase per 1 kg of patient weight, especially in cystic fibrosis.
Side effects
- from the digestive system: rarely - epigastric discomfort, nausea, abdominal pain, diarrhea, constipation, decreased endogenous synthesis of bile acids; when used in high doses for a long period - hyperuricosuria; while taking high doses with cystic fibrosis - strictures in the ileocecal and ascending colon, which are manifested by symptoms of intestinal obstruction;
- from the immune system: allergic reactions.
Overdose
Symptoms: hyperuricemia, with prolonged use of high doses of the drug - hyperuricosuria. In patients with cystic fibrosis, high doses can cause strictures in the ileocecal and ascending colon. Overdose in children is accompanied by the development of constipation.
Treatment: cancellation of Pancreatin forte, the appointment of symptomatic therapy.
special instructions
Care should be taken when determining the dose of the drug for patients with cystic fibrosis, its size should correspond to the amount of food consumed and the quality composition.
For patients with normal pancreatic function, if it is necessary to use Pancreatin forte for a long time in order to normalize digestion, it is recommended to simultaneously prescribe iron preparations.
Influence on the ability to drive vehicles and complex mechanisms
The use of Pancreatin forte does not affect the ability of patients to perform potentially hazardous activities, including driving vehicles and mechanisms.
Application during pregnancy and lactation
It is allowed to prescribe Pancreatin forte tablets during gestation and breastfeeding only in cases where the expected therapeutic effect for the mother justifies the potential risk to the fetus or child.
Pediatric use
The use of Pancreatin forte for the treatment of children under the age of three is contraindicated, which is associated with the dosage form of the drug.
Drug interactions
With the simultaneous use of Pancreatin forte:
- antibacterial agents, paraaminosalicylic acid, sulfonamides: it should be borne in mind that pancreatic enzymes enhance the absorption of these drugs;
- iron preparations: the degree of absorption of iron decreases, especially with prolonged therapy;
- antacids containing magnesium hydroxide and / or calcium carbonate: reduce the effectiveness of pancreatin.
Analogs
Pancreatin forte analogs are Pancreatin, Pancreatin 10,000, Pancreatin-Health, Pancreatin-LekT, Ermital, Gastenorm forte, Gastenorm forte 10,000, Creon 10,000, Creon 25,000, Creon 40,000, Creon Micro, Mezim 20000, Mezim forte, Mezim forte Micrasim, Pangrol 25000, PanziKam, Panzim Forte, Pancreasim, Penzital, Enzistal-P, etc.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C, protected from moisture.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Pancreatin Fort
Reviews about Pancreatin Fort are positive. Patients note the high efficiency of the drug. Its action allows you to quickly stop pain in the pancreas, relieve the feeling of heaviness in the stomach when overeating or eating heavy food, and restore the digestive system.
Price for Pancreatin forte in pharmacies
The price of Pancreatin forte enteric-coated tablets per pack can be: 20 pcs. - from 35 rubles, 60 pcs. - from 82 rubles.
Pancreatin forte: prices in online pharmacies
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Drug name Price Pharmacy |
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Pancreatin forte enteric-coated tablets 20 pcs. RUB 51 Buy |
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Pancreatin forte tab. p / o intestinal. No. 20 RUB 58 Buy |
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Pancreatin forte enteric-coated tablets 60 pcs. RUB 98 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
