Panzinorm forte 20,000
Panzinorm forte 20 000: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Panzinorm forte 20 000
ATX code: A09AA02
Active ingredient: Pancreatin (Pancreatin)
Manufacturer: KRKA (Slovenia)
Description and photo update: 19.10.2018
Panzinorm forte 20 000 is an enzymatic medicine for the normalization of digestion.
Release form and composition
Panzinorm forte 20,000 is produced in the form of enteric-coated tablets: round, biconvex, with a glossy surface, with a characteristic vanilla and bergamot aroma, the shell is from white to light gray (10 pcs. In blisters, in a cardboard box 1, 3 or 10 blisters; 10, 30 or 100 pcs. In amber glass vials, in a cardboard box 1 bottle).
Composition for 1 tablet:
- active substance: pork pancreatin [with enzyme activity of the components: lipase - 20,000 European Pharmacopoeia Units (EEF); amylase - 12,000 UUF and protease - 900 UUF] - 269.12-279.44 mg *;
- excipients: microcrystalline cellulose, lactose monohydrate, crospovidone, magnesium stearate, colloidal anhydrous silicon dioxide;
- enteric shell: triethyl citrate, hypromellose, methacrylic acid and ethyl acrylate copolymer, titanium dioxide (E171), talc, simethicone emulsion, vanilla flavor 54286 C and bergamot 54253 T, sodium carmellose, macrogol 6000, polysorbate 80.
* Excessive amount of pancreatin for technical losses in the production process - 15%; an excess amount of pancreatin, laid down to compensate for losses from the decomposition of the active substance during storage - 10%.
Pharmacological properties
Pharmacodynamics
Panzinorm forte 20,000 has a compensatory effect in case of insufficiency of the exocrine function of the pancreas (pancreas) to release pancreatic juice containing digestive enzymes.
The action of the combined preparation is due to the enzymes that make up it:
- lipase - breaks down fats by hydrolysis into fatty acids and glycerol, promoting their absorption and improving the absorption of fat-soluble vitamins;
- amylase - breaks down starch and other carbohydrates into sugars and dextrins;
- protease - breaks down proteins.
Thanks to the enteric-soluble protective membrane, active enzymes are released directly in the small intestine, where they begin to participate in the digestion of incoming food, contributing to a more complete absorption of proteins, fats and carbohydrates into the intestinal walls. Pancreatin eliminates diarrhea and symptoms of impaired digestion caused by the accumulation of gas in the intestines: flatulence, a feeling of heaviness / fullness in the stomach, shortness of breath, feeling of lack of air. Panzinorm forte 20,000 improves the digestive process in children and stimulates the production and secretion of its own enzymes in the pancreas, small intestine, stomach and bile.
Pharmacokinetics
Since pancreatic enzymes are protected from the action of gastric juice by a film membrane, they are released from the drug in the alkaline environment of the small intestine. A small amount of digestive enzymes is secreted through the intestines.
Indications for use
- exocrine insufficiency of pancreatic function due to chronic pancreatitis, cystic fibrosis, etc.;
- inflammatory-dystrophic diseases of the digestive system (stomach, intestines, liver, gallbladder) in the chronic stage, conditions after irradiation or removal of these organs, accompanied by indigestion, diarrhea, flatulence - as part of a comprehensive treatment;
- errors in nutrition as a result of impaired chewing function (injury and destruction of teeth, gum disease, addiction to dentures), a sedentary lifestyle, prolonged immobilization of patients with normal functioning of the gastrointestinal tract (gastrointestinal tract) - to improve food digestion;
- preparation period for X-ray and ultrasound diagnostics of the abdominal organs.
Contraindications
Absolute:
- acute pancreatitis, chronic pancreatitis in the acute phase;
- children under 3 years old;
- children under 15 years of age with cystic fibrosis;
- hypersensitivity to pork protein and other substances of the drug.
According to the instructions, Panzinorm forte 20,000 is prescribed with caution during pregnancy.
Instructions for the use of Panzinorm forte 20 000: method and dosage
Panzinorm forte 20,000 tablets are taken orally, simultaneously with meals, without chewing and drinking enough liquid.
The doctor determines the dose and duration of treatment individually, depending on the age of the patient and the severity of pancreatic insufficiency.
Recommended dosing regimen for adult patients in the absence of other prescriptions:
- treatment and improvement of digestion: in the initial period - 1 tablet 3 times a day with each main meal or taking a light snack, if necessary, an increase in a single dose to 2 tablets is allowed; in the future, the average dose is 1-2 tablets 3 times a day;
- preparation for X-ray / ultrasound examination: 2 tablets 2-3 times a day 2-3 days before the procedure.
Children over 3 years of age take the drug as prescribed by a doctor at the rate of 100 thousand units per day (in terms of lipase).
The duration of the course of therapy varies in a wide range: from taking the drug once or for several days (to normalize the digestive process after a diet disorder) to several months or even years (in case of need for constant substitution therapy).
Side effects
When using Panzinorm forte 20,000, the following side effects on the part of systems and organs may develop:
- digestive system (long-term use of high doses): abdominal pain (including intestinal colic), nausea, vomiting, diarrhea, constipation, irritation of the oral mucosa, perianal irritation; with cystic fibrosis (excess of the required dose of pancreatin ≥ 10,000 UUF lipase per 1 kg of body weight), strictures (fibrous colonopathy) may develop in the ileocecal part of the intestine and in the ascending colon;
- hypersensitivity reactions: sneezing, choking, hyperemia of the skin, skin rash and / or itching, lacrimation;
- other reactions: hyperuricosuria, hyperuricemia, folate deficiency.
Overdose
Overdose symptoms are: nausea / vomiting, diarrhea, hyperuricemia, hyperuricosuria, perianal irritation, fibrous colonopathy in patients with cystic fibrosis.
To treat the condition, you should stop taking Panzinorm forte 20,000, hydrate and, if necessary, symptomatic treatment.
special instructions
It is not recommended to chew Panzinorm forte 20 000 tablets, they should be taken with a sufficient amount of liquid.
In order to avoid the development of strictures in the ileocecal part of the intestine and the ascending colon, which is possible in patients with cystic fibrosis with an accidental overdose of pancreatin ≥ 10,000 UUF lipase per 1 kg of body weight, it is necessary to strictly maintain the dose. It should correspond to the amount of enzymes required to absorb fat, taking into account the quality and volume of food consumed.
The hydrosorbent capsule contained in the package with the preparation must not be swallowed!
Influence on the ability to drive vehicles and complex mechanisms
There was no information on the negative effect of pancreatin on the speed of psychomotor reaction and concentration of attention required to perform potentially hazardous types of work.
Application during pregnancy and lactation
There are no clinical data confirming the safety of the use of pancreatic enzymes during pregnancy and during breastfeeding. Prescribing Panzinorm forte 20,000 during these periods is allowed only if the expected positive effect of therapy for the mother exceeds the possible risks to the fetus / child.
Pediatric use
In children over 3 years old, Panzinorm forte 20,000 is used according to indications.
Drug interactions
Pancreatin can reduce the absorption of folic acid preparations and is clinically insignificant - the absorption of iron-containing preparations, in connection with which periodic monitoring of folate levels and / or additional prescription of folic acid preparations is recommended.
Panzinorm forte 20,000 tablets are produced in a special acid-resistant shell and dissolve in the duodenum. But with insufficient acidity of the duodenum, pancreatin is not released.
Hydrocarbonates, blockers of H 2 -histamine receptors (cimetidine), proton pump inhibitors, when used simultaneously with pancreatin, can enhance its effectiveness.
Analogs
The analogues of Panzinorm Forte 20 000 are: Panzinorm Forte-N, Biozyme, Gastenorm Forte, Kreon, Micrasim, Mezim, Pangrol, Panzim Forte, PanziKam, Panzinorm, Pancreazim, Pancrelipaza, Pancrenorm, Pancreatin, Pancitrat, Penzital, Nizital, Uni-Festal, Hermital.
Terms and conditions of storage
Store in original packaging at low humidity and temperature not exceeding 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Panzinorm Forte 20 000
According to reviews, Panzinorm Forte 20,000 is a high-quality, effective and inexpensive enzyme preparation that provides a quick positive effect on the normalization of digestion.
Of the shortcomings, in exceptional cases, there were unpleasant side reactions and the return of pain after taking the pills.
Price for Panzinorm Forte 20 000 in pharmacies
The estimated price for Panzinorm Forte 20,000 is: for 10 tablets in a package ~ 110 rubles; for 30 tablets in a package ~ 251 rubles; for 100 tablets in a package ~ 457 rubles.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
