Teraflex
Teraflex: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price in pharmacies
Latin name: Theraflex
ATX code: М01ВХ
Active ingredient: chondroitin sulfate + glucosamine (chondroitini sulfas + glucosamine)
Manufacturer: Contract Pharmacal Corporation (USA)
Description and photo update: 2019-19-08
Prices in pharmacies: from 170 rubles.
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Teraflex is a complex drug with anti-inflammatory and analgesic effect, which regulates metabolism in cartilage tissue.
Release form and composition
Dosage form of the drug - capsules: size No. 0, gelatinous solid transparent; contents - powder with crystalline inclusions of white or white-yellowish color, odorless or with a weak specific odor (30, 60 or 100 pcs. in polyethylene bottles, 1 bottle in a cardboard box).
Active ingredients in 1 capsule:
- glucosamine hydrochloride - 0.5 g;
- chondroitin sodium sulfate - 0.4 g
Additional components: manganese sulfate, stearic acid, magnesium stearate.
Pharmacological properties
Pharmacodynamics
The drug is a stimulator of cartilage tissue regeneration. Chondroitin sulfate and glucosamine are involved in the synthesis of connective tissue, activating its regeneration and preventing the destruction of cartilage. The entry of exogenous glucosamine into the body enhances the production of cartilage matrix and is a factor of nonspecific protection against cartilage damage of chemical origin. It is also believed that glucosamine protects damaged cartilage from metabolic destruction caused by glucocorticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs), and also moderately has its own anti-inflammatory effect.
Chondroitin Sulfate is an additional substrate that contributes to the formation of a healthy cartilage matrix. It enhances the production of type II collagen and proteoglycans, the synthesis of hyaluronone, and also prevents the enzymatic destruction of hyaluronon by inhibiting the activity of hyaluronidase, inhibits the activity of enzymes involved in the breakdown of cartilage (hyaluronidase, elastase), and stimulates the mechanisms of cartilage repair. In patients with osteoarthritis, chondroitin sulfate reduces the severity of symptoms of the disease and reduces the need for NSAIDs.
Pharmacokinetics
Glucosamine
When taken orally, the bioavailability of glucosamine is 25%, and it is characterized by a "first pass" effect through the liver. After the absorption of a dose of the drug taken orally, the radioactively labeled substance is first detected in the blood plasma, after which it penetrates the tissues. Its maximum concentrations are found in the articular cartilage, kidneys and liver. Approximately 30% of the dose taken persists in muscle and bone tissues for a long time.
Glucosamine is excreted mainly in the urine unchanged, and also partially in feces. The half-life is 68 hours.
Chondroitin sulfate
With a single oral administration of chondroitin sulfate in a dose of 0.8 g (or 0.4 g 2 times a day), its concentration in blood plasma increases within 24 hours. The absolute bioavailability reaches 12%.
Chondroitin sulfate is metabolized by desulfurization. It is excreted through the kidneys and has a half-life of 310 minutes.
Indications for use
According to the instructions, Teraflex is a drug for the treatment of degenerative-dystrophic diseases of the spine and joints, such as osteochondrosis and osteoarthritis of I-III degrees.
Contraindications
Absolute:
- age up to 15 years;
- severe chronic renal failure;
- period of pregnancy and lactation;
- hypersensitivity to the components of the drug.
Relative (the drug is taken with caution):
- diabetes;
- bronchial asthma;
- predisposition to bleeding.
Instructions for use of Teraflex: method and dosage
Teraflex should be taken orally, swallowing the capsules whole with plenty of water. Food does not affect the effectiveness of the drug.
Teraflex is usually prescribed for adolescents over 15 years old and adult patients according to the following scheme: for the first 3 weeks - 1 capsule 3 times a day, then - 1 capsule 2 times a day.
The duration of therapy, depending on the clinical situation, is 3–6 months. Repeated courses are carried out if necessary.
Side effects
Teraflex usually does not cause side effects.
In some cases, the following undesirable reactions from some systems and organs are noted:
- Gastrointestinal tract (gastrointestinal tract): flatulence, constipation (in some patients, on the contrary, diarrhea), pain in the epigastric region;
- nervous system: drowsiness or insomnia, headache, dizziness;
- CVS (cardiovascular system): peripheral edema, tachycardia;
- others: leg pain, allergic reactions.
Overdose
There are practically no reports of Teraflex overdose cases. An overdose of chondroitin sulfate can lead to nausea, vomiting, and hemorrhagic rash. Gastric lavage and symptomatic therapy are recommended as treatment.
special instructions
In case of development of side effects from the digestive system, it is recommended to reduce the dose by 2 times, if there is no improvement, the drug should be canceled.
Application during pregnancy and lactation
There are no clinical data indicating the safety and efficacy of Teraflex during pregnancy and lactation.
Drug interactions
Teraflex is compatible with GCS (glucocorticosteroids) and NSAIDs (non-steroidal anti-inflammatory drugs).
The drug reduces the effect of chloramphenicol and semisynthetic penicillins, improves the absorption of tetracyclines, enhances the effect of anticoagulants.
Analogs
Teraflex analogs are: Dona, Structum, Mucosat, Artra, Kondronova, Chondrogluxid, Glucosamine Chondroitin complex, Chondroxide, Chondrogard.
Terms and conditions of storage
Keep out of the reach of children, in a dry place, at temperatures up to 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Teraflex
Numerous reviews about Teraflex found on the Internet are contradictory. Some patients are enthusiastic about the drug, others consider it absolutely useless. Many patients report that the course of treatment with Teraflex allowed them to increase the mobility of the joints and get rid of pain and crunch in them. However, even those who have significantly improved their health after taking the drug complain about its high cost.
Reviews of experts about Teraflex are ambiguous (there are both positive and negative) and depend on their belief in the effectiveness of glucosamine and chondroitin sulfate in the treatment of joints and belief in the assimilation of these substances of exogenous origin. In general, the effect of the drug is more pronounced in cases where the course of therapy lasts at least 6 months, and the severity of the disease is not considered too severe. The advantages of Teraflex include the possibility of using it both as monotherapy and in combination with anti-inflammatory drugs and other methods of treatment.
Price for Teraflex in pharmacies
The average price for Teraflex is 1,362–1808 rubles (for a package containing 60 capsules), 1,869–2434 rubles (for a package containing 100 capsules), or 3348‒3926 rubles (for a package containing 200 capsules).
Teraflex: prices in online pharmacies
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Drug name Price Pharmacy |
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Teraflex Hondrocrem Forte 1% + 5% cream for external use 30 g 1 pc. 170 RUB Buy |
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Teraflex Hondrocrem Forte cream for outside. approx. 1% + 5% tube 50g 310 RUB Buy |
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Teraflex Hondrocrem Forte 1% + 5% cream for external use 50 g 1 pc. 310 RUB Buy |
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Teraflex Hondrocrem Forte 1% + 5% cream for external use 100 g 1 pc. 476 r Buy |
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Teraflex Hondrocrem Forte cream for outside. approx. 1% + 5% tube 100g RUB 499 Buy |
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Teraflex Advance 250 mg + 100 mg + 200 mg capsules 60 pcs. RUB 1000 Buy |
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Reviews Teraflex Advance RUB 1000 Buy |
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Teraflex 500 mg + 400 mg capsules 60 pcs. 1049 RUB Buy |
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Teraflex capsules 60 pcs 1347 RUB Buy |
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Teraflex 500 mg + 400 mg capsules 100 pcs. 1424 RUB Buy |
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Teraflex Advance capsules 60 pcs. 1498 RUB Buy |
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Teraflex Advance 250 mg + 100 mg + 200 mg capsules 120 pcs. 1600 RUB Buy |
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Teraflex capsules 400mg + 500mg 100 pcs. 1974 RUB Buy |
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Teraflex 500 mg + 400 mg capsules 200 pcs. 2202 RUB Buy |
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Teraflex Advance capsules 120 pcs. 2282 RUB Buy |
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Teraflex caps. 500 mg + 400 mg 200 pcs. RUB 3040 Buy |
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Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
