Endothelon
Endothelon: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Drug interactions
- 11. Analogs
- 12. Terms and conditions of storage
- 13. Terms of dispensing from pharmacies
- 14. Reviews
- 15. Price in pharmacies
Latin name: Endotelon
ATX code: C05B
Active ingredient: oligomers of procyanidolic seeds of cultivated grapes
Producer: Sanofi-Winthrop Industrie (France)
Description and photo update: 2018-27-07
Endothelon is a phytopreparation used in the treatment of disorders of venous circulation.
Release form and composition
The dosage form of the release is enteric-coated tablets: yellow, round, shiny, smooth, with a faint odor or odor (in a cardboard box, 2 blisters, 10 pcs. In each).
Composition of 1 tablet:
- active substance: procyanidol oligomers of cultivated grape seeds - 150 mg;
- auxiliary components: microcrystalline cellulose - 50 mg; magnesium stearate - 4 mg; colloidal silicon dioxide - 1 mg;
- enteric coating: copolymer of ethacrylate and methacrylic acid (1: 1) - 14.707 mg; triethyl citrate - 1.47 mg; sodium hydroxide - 0.22 mg; talc - 3.603 mg;
- sugar coat: gelatin - 0.139 mg; sucrose - 211.009 mg; acacia gum - 6.015 mg; dye iron oxide yellow (E172) - 0.129 mg; titanium dioxide (E171) - 35.472 mg; carnauba wax - traces.
Pharmacological properties
Pharmacodynamics
The active substances of the water-soluble extract prepared from grape seeds (Vitis vinifera) are procyanidolic oligomers. Thanks to their action, structural proteins, collagen and elastin are protected from thermal denaturation and enzymatic degradation.
Endothelon lowers capillary permeability and increases venous tone.
Pharmacokinetics
Biologically active substances of Endothelon are rapidly absorbed in the gastrointestinal tract, binding occurs mainly with glycosaminoglycans, including perivascular connective tissue.
The maximum plasma concentration in the blood is reached after 90 minutes, the half-life is 72 hours.
Most (about 70%) of Endothelon and its metabolites are excreted through the intestines, about 20% - by the kidneys, 5% - by the lungs.
Indications for use
- initial (functional) manifestations of venous and lymphatic insufficiency (in the form of heaviness / pain in the legs, tired legs syndrome);
- lymphostasis of the upper extremities after radiation therapy or surgery for breast cancer - as monotherapy when the patient is unable to use physical methods of treatment, which are the first choice treatment; as an adjunct to physical treatments, especially wearing an elastic sleeve;
- complications associated with microcirculation disorders in the choroid and retina.
Contraindications
- fructose intolerance, glucose or galactose malabsorption syndrome, or sucrose-isomaltose deficiency;
- pregnancy and the period of breastfeeding;
- individual intolerance to any component of the drug.
Instructions for the use of Endothelon: method and dosage
According to the instructions, Endothelon is taken orally with a certain interval after a meal.
The recommended dosing regimen in lymphological and phlebological practice: 2 times a day (in the morning and in the evening), 1 tablet.
In the treatment of functional manifestations of venous / lymphatic insufficiency, the drug should be taken until a clinical effect is achieved for 20 days a month. In case of use after radiation therapy / surgery for breast cancer, Endothelon should be taken for a long time and continuously.
In ophthalmic practice, the drug is prescribed in a daily dose of 100–150 mg.
Side effects
- immune system: very rarely - allergic skin reactions, including urticaria, skin rash with or without itching, eczema, photosensitization (are reversible); in some cases - Quincke's edema;
- digestive system: very rarely - diarrhea, nausea, discomfort in the epigastric region;
- nervous system: in some cases - headache.
Overdose
There is no information.
special instructions
In cases of persistent persistence of local symptoms or when new ones appear, you should consult a doctor.
Application during pregnancy and lactation
Due to the lack of experience in clinical use, Endothelon is not prescribed during pregnancy / lactation.
Drug interactions
There are no data on the interaction of Endothelon with other drugs / substances.
Analogs
The analogues of Endothelon are Herbion Esculus and Cyclo 3.
Terms and conditions of storage
Keep out of reach of children at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Endothelon
Reviews of Endothelon are few, due to its absence in pharmacies.
Price for Endothelon in pharmacies
The price of Endothelon is unknown, since the drug is not available in pharmacies.
Approximate price of analogs: Herbion esculus (1 tube of 40 g) - from 100 rubles; Reparil - from 175 rubles; Venitan - from 198 rubles.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
