Ezlor
Ezlor: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Ezlor
ATX code: R06AX
Active ingredient: desloratadine (desloratadine)
Manufacturer: Ozone, LLC (Russia)
Description and photo updated: 22.11.2018
Prices in pharmacies: from 80 rubles.
Buy
Ezlor is a drug with antiallergic effect.
Release form and composition
Ezlor's dosage form is film-coated tablets: cylindrical biconvex, the core and shell are white or almost white (in a cardboard box 1-6, 8 or 10 blisters of 10 tablets or 1 polymer can of 10, 20, 30, 40, 50 or 100 tablets).
Composition of 1 tablet:
- active substance: desloratadine - 5 mg;
- auxiliary components: lactose monohydrate - 70 mg; microcrystalline cellulose - 12.1 mg; povidone - 3 mg; magnesium stearate - 0.9 mg; croscarmellose sodium - 4 mg;
- shell: white Opadry II 85F48105 - 3 mg (including: polyvinyl alcohol - 1.407 mg; macrogol 3350 - 0.708 mg; talc - 0.522 mg; titanium dioxide - 0.363 mg).
Pharmacological properties
Pharmacodynamics
Desloratadine, the primary active metabolite of loratadine, is a long-acting H 1 histamine receptor blocker.
The therapy allows you to prevent the appearance, and also facilitates the course of allergic reactions. Ezlor has an antipruritic and anti-exudative effect, reduces capillary permeability, prevents smooth muscle spasm and tissue edema.
The drug does not affect the central nervous system, practically does not have a sedative effect (does not cause drowsiness), does not cause prolongation of the QT interval on the ECG, does not change the speed of psychomotor reactions.
Ezlor develops within 30 minutes after oral administration, and lasts 24 hours.
Pharmacokinetics
After oral administration, desloratadine is well absorbed from the gastrointestinal tract. Determined plasma concentrations in the blood are reached within 30 minutes, the time to reach the maximum concentration is approximately 3 hours.
Binds to plasma proteins - in the range from 83 to 87%. When used for 14 days 1 time a day, 5–20 mg in adults and adolescents, there is no clinically significant accumulation of the substance. Simultaneous food intake / consumption of grapefruit juice does not affect the distribution of desloratadine (when taken once a day at a dose of 7.5 mg). The substance does not penetrate through the blood-brain barrier.
Desloratadine undergoes intensive metabolism in the liver by hydroxylation to form 3-OH-desloratadine combined with glucuronide. It is not an inhibitor of CYP3A4 and CYP2D6 isoenzymes, as well as a substrate / inhibitor of P-glycoprotein.
A small amount of the dose taken is excreted unchanged: by the kidneys - less than 2%; through the intestines - less than 7%. The half-life (T 1/2) varies in the range of 20-30 hours (on average - 27 hours).
Indications for use
- allergic rhinitis: to eliminate / relieve itching in the nose and palate, nasal congestion, sneezing, watery eyes, nasal mucus, redness / itching of the eyes;
- urticaria: to reduce / eliminate itching, rash.
Contraindications
Absolute:
- lactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome;
- pregnancy and the period of breastfeeding;
- age up to 12 years;
- individual intolerance to the components of the drug.
In severe renal failure, Ezlor should be used under medical supervision.
Instructions for the use of Ezlor: method and dosage
Ezlor tablets are taken orally with a small amount of water, preferably at the same time of day. The tablet should not be divided or chewed. The effectiveness of therapy does not depend on the time of the meal.
Recommended dosage regimen: 1 tablet once a day.
Side effects
Possible adverse reactions (> 10% - very common;> 1% and 0.1% and 0.01% and <0.1% - rarely; <0.01% - very rare):
- central nervous system: infrequently - headache; very rarely - insomnia, hallucinations, convulsions, drowsiness, dizziness, psychomotor hyperactivity;
- immune system: very rarely - rash, dyspnea, urticaria, angioedema, anaphylactic shock;
- digestive system: infrequently - xerostomia; very rarely - dyspepsia, nausea, vomiting, diarrhea, increased activity of liver enzymes, abdominal pain, hepatitis, increased concentration of bilirubin;
- cardiovascular system: very rarely - palpitations, tachycardia;
- musculoskeletal system: very rarely - myalgia;
- others: often - increased fatigue.
Overdose
According to clinical and pharmacological studies, taking desloratadine in a daily dose of 45 mg for 10 days did not lead to the development of serious adverse reactions.
Therapy: gastric lavage, intake of activated carbon; if necessary, symptomatic treatment is indicated. Desloratadine is not excreted during hemodialysis, and the effectiveness of peritoneal dialysis has not been determined.
special instructions
There is no information.
Application during pregnancy and lactation
According to the instructions, Ezlor is not prescribed during pregnancy / lactation.
Pediatric use
Ezlor tablets are not prescribed for patients under 12 years of age.
With impaired renal function
Ezlor therapy in patients with severe renal failure should be carried out under medical supervision.
Drug interactions
No interaction of Ezlor with other drugs / substances has been identified.
Analogs
Ezlor's analogues are Lordestin, Elisey, Desloratadin, Nalorius, Blogir-3, Alestamin, Erius, Desal.
Terms and conditions of storage
Store in a place protected from light at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Ezlor
According to reviews, Ezlor quickly relieves the symptoms of allergic reactions - urticaria and rhinitis. The main advantage of the drug is the absence of adverse reactions, especially drowsiness. A convenient dosing regimen is also noted. Of the shortcomings, I point out the high cost of the drug.
Price for Ezlor in pharmacies
The approximate price for Ezlor (10 tablets) is 293–442 rubles.
Ezlor: prices in online pharmacies
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Drug name Price Pharmacy |
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Ezlor 5 mg film-coated tablets 10 pcs. RUB 80 Buy |
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Ezlor Solution Tablets 5 mg dispersible tablets 10 pcs. 265 RUB Buy |
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Reviews of Ezlor Solution Tablets 265 RUB Buy |
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Ezlor solution tablets tab. dispersion 5 mg 10 pcs. 272 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
