Presartan
Presartan: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. In case of impaired liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Presartan
ATX code: C09CA01
Active ingredient: losartan (losartan)
Manufacturer: Ipca Laboratories, Ltd. (India)
Description and photo update: 2018-25-10
Prices in pharmacies: from 123 rubles.
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Presartan is an antihypertensive drug.
Release form and composition
Dosage form of Presartan - film-coated tablets: in a dosage of 25 and 50 mg - round, biconvex, pink, 25 mg tablets with a dividing line on one side; in a dosage of 100 mg - drop-shaped, biconvex, white or almost white with an engraving "100" on one side and "BL" on the other (10 pcs. in a blister, in a cardboard box 3 blisters; 14 pcs. in a blister, in a cardboard box box 2 blisters).
Composition of 1 tablet 25/50 mg:
- active substance: losartan potassium - 25/50 mg;
- auxiliary components: dried starch, microcrystalline cellulose, purified talc, colloidal silicon dioxide, sodium starch glycolate, magnesium stearate, isopropyl alcohol, methylene chloride, opad OY-55030, crimson red dye.
Composition of 1 tablet 100 mg:
- active substance: losartan potassium - 100 mg;
- auxiliary components: corn starch, microcrystalline cellulose, talc, colloidal silicon dioxide, sodium carboxymethyl starch, magnesium stearate, hypromellose, titanium dioxide, talc, macrogol.
Pharmacological properties
Pharmacodynamics
Presartan is a specific angiotensin receptor blocker (type AT1). Does not inhibit kinase II, an enzyme that breaks down bradykinin. Losartan lowers the total peripheral vascular resistance, blood pressure (BP), afterload and pressure in the pulmonary circulation. Reduces the concentration of aldosterone and norepinephrine in the blood. It has a diuretic effect. Has an inhibitory effect on myocardial hypertrophy. Increases resistance to physical activity in patients with chronic heart failure.
The hypotensive effect reaches its maximum in the case of a single dose of the drug after 6 hours, and gradually decreases during the day. After the start of the course of taking Presartan, its maximum effect is achieved on average in a month.
Pharmacokinetics
Presartan is rapidly absorbed from the gastrointestinal tract (GIT). Metabolized by first passage through the liver. The degree of binding to blood plasma proteins of losartan and its metabolites is 92–99%. Bioavailability - 33% (food intake has no effect). The drug practically does not penetrate the blood-brain barrier. It does not accumulate in the body; it is excreted in urine and bile. The half-life of losartan is 2 hours.
Indications for use
- arterial hypertension and left ventricular hypertrophy (to reduce the risk of developing cardiovascular pathologies and mortality);
- type II diabetes mellitus with proteinuria (to reduce the risk of developing proteinuria and hypercreatininemia);
- chronic heart failure [used as part of combination therapy when it is impossible to use angiotensin-converting enzyme (ACE) inhibitors].
Contraindications
Absolute contraindications:
- severe liver failure ˃ 9 points on the Child-Pugh scale (for 100 mg tablets);
- pregnancy and lactation;
- age up to 18 years;
- increased sensitivity to the components of Presartan.
Relative contraindications (for 100 mg tablets):
- gout;
- hyperuricemia;
- allergic reactions during previous therapy with ACE inhibitors or other drugs;
- bronchial asthma;
- systemic blood diseases;
- reduced volume of circulating blood (BCC);
- arterial hypotension;
- co-administration with non-steroidal anti-inflammatory drugs (NSAIDs);
- cardiac ischemia;
- elderly age.
Instructions for the use of Presartan: method and dosage
Presartan tablets are taken orally 1 time per day, regardless of the meal.
Dosing according to indications:
- arterial hypertension: the recommended initial dose is 25 mg / day, the average dose is 50 mg / day, if necessary, it can be increased to 100 mg / day, while taking the drug 2 times a day;
- heart failure: the recommended initial dose is 12.5 mg / day, the dose is titrated at weekly intervals. The average maintenance dose is 50 mg / day;
- prevention of cardiovascular pathologies and mortality in patients with arterial hypertension and left ventricular hypertrophy: the recommended initial dose is 50 mg / day, then it is increased to 100 mg / day, or a joint administration of hydrochlorothiazide is prescribed;
- type II diabetes mellitus with proteinuria: the recommended initial dose is 50 mg / day, then it is increased to 100 mg / day.
Special patient groups:
- liver failure (˂ 9 points on the Child-Pugh scale), taking high doses of diuretics, hemodialysis, over 75 years of age: the initial dose of the drug should not exceed 25 mg / day;
- liver dysfunction: lower doses of the drug should be used.
Side effects
Presartan 25 mg and 50 mg are generally well tolerated. Side reactions may occur in the form of diarrhea, dyspepsia, muscle pain, swelling, headache, dizziness, sleep disturbances, hyperkalemia (potassium concentration> 5.5 meq / l); in rare cases - cough, respiratory failure, tachycardia, angioedema (lips, face, pharynx and / or tongue), urticaria, increased activity of liver enzymes, serum bilirubin.
Possible side effects when taking Presartan 100 mg tablets:
- cardiovascular system: tachycardia, palpitations, epistaxis, dose-dependent orthostatic hypotension, arrhythmias, bradycardia, vasculitis, angina pectoris, myocardial infarction;
- digestive system: diarrhea, abdominal pain, nausea, dyspepsia, dryness of the oral mucosa, anorexia, vomiting, toothache, constipation, gastritis, flatulence, hepatitis, liver dysfunction;
- musculoskeletal system: cramps of the calf muscles, pain in the back and legs, arthralgia, arthritis, pain in the shoulder, knee, fibromyalgia;
- skin: erythema, dry skin, ecchymosis, photosensitivity, alopecia, increased sweating;
- allergic reactions: skin rash, itching, urticaria, angioedema (including swelling of the larynx, tongue);
- hematopoiesis: thrombocytopenia, eosinophilia, Shenlein-Henoch purpura, a slight decrease in hemoglobin and hematocrit;
- nervous system: headache, dizziness, insomnia, anxiety, drowsiness, sleep disturbances, memory disturbances, paresthesia, hypoesthesia, peripheral neuropathy, tremor, ataxia, depression, ringing in the ears, fainting, taste disturbances, migraine, conjunctivitis, visual disturbances;
- respiratory system: cough, pharyngitis, bronchitis, nasal congestion, sinusitis, upper respiratory tract infections;
- genitourinary system: urinary tract infections, urge to urinate, impaired renal function, decreased libido, impotence;
- other: asthenia, chest pain, increased fatigue, peripheral edema, exacerbation of gout;
- laboratory parameters: hyperuricemia, increased concentration of urea, residual nitrogen and creatinine in the blood serum, increased activity of hepatic transaminases (moderate), hyperbilirubinemia.
Overdose
Symptoms of an overdose of Presartan: tachycardia and a marked decrease in blood pressure, parasympathetic stimulation can cause bradycardia.
For treatment, forced diuresis and symptomatic therapy are indicated. Hemodialysis is ineffective.
special instructions
Yes, when you start taking Presartan, you should correct dehydration caused, for example, by taking diuretics in high doses, if there is no way to correct the BCC, treatment should be started with a low dose of the drug.
Drugs acting on the RAAS (renin-angiotensin-aldosterone system) can increase the concentration of urea in the blood and serum creatinine in patients with bilateral renal artery stenosis or stenosis of the artery of a single kidney.
Influence on the ability to drive vehicles and complex mechanisms
Special studies on the effect of Presartan on the ability to drive vehicles and other complex mechanisms have not been conducted. However, one should take into account the development of possible side effects, such as drowsiness and dizziness, requiring increased caution when engaging in potentially hazardous activities.
Application during pregnancy and lactation
It is contraindicated to use Presartan during pregnancy.
Due to the fact that the issue of the release of losartan into breast milk has not been studied, if it is necessary to take the drug during lactation, breastfeeding should be discontinued.
Pediatric use
According to the instructions, Presartan is prohibited for use in pediatrics for the treatment of children and adolescents under 18 years of age.
With impaired renal function
Patients with impaired renal function, including those on hemodialysis, do not need to adjust the initial dose of Presartan.
If liver function is impaired
With cirrhosis of the liver, the concentration of losartan in the blood increases significantly, and therefore patients with liver diseases need to reduce the dose of Presartan.
Use in the elderly
In elderly patients with impaired renal function, potassium levels in the blood should be monitored regularly.
Drug interactions
- potassium-sparing diuretics, potassium preparations: risk of developing hyperkalemia;
- diuretics: the risk of a pronounced sharp decrease in blood pressure;
- beta-blockers and sympatholytics: enhances their effect;
- rifampicin, flucanazole: reduce the concentration of the active metabolite of losartan in the blood;
- lithium: an increase in its concentration in the blood is possible;
- NSAIDs: the hypotensive effect of the drug decreases;
- other antihypertensive drugs: their mutual antihypertensive effect is enhanced.
Analogs
The analogues of Presartan are Brozaar, Bloktran, Vasotenz, Zisakar, Kozaar, Lozap, Cardomin-Sanovel, Losartan, Renikard, Lakea, Vero-Losartan, Lorista.
Terms and conditions of storage
Store in a dry place, away from light, at a temperature not exceeding 25 ° C. Keep out of the reach of children.
Shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Presartan
Reviews about Presartan on the network are positive. Patients report an improvement in their well-being, and doctors speak of a long-term and stable antihypertensive effect, in the absence of episodes of hypotension.
Price for Presartan in pharmacies
The estimated price for Presartan is 145 rubles. per package containing 30 tablets of 50 mg.
Presartan: prices in online pharmacies
|
Drug name Price Pharmacy |
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Prezartan 50 mg film-coated tablets 30 pcs. 123 r Buy |
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Prezartan 100 mg film-coated tablets 28 pcs. 172 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
