Pentalgin-ICN - Instructions For Use, Composition, Reviews, Price Of Tablets

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Pentalgin-ICN

Pentalgin-ICN: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Use in the elderly
14. 14. Drug interactions
15. 15. Analogs
16. 16. Terms and conditions of storage
17. 17. Terms of dispensing from pharmacies
18. 18. Reviews
19. 19. Price in pharmacies

Latin name: Pentalgin-ICN

ATX code: N02BB72

Active ingredient: codeine (codeine) + caffeine (caffeine) + metamizole sodium (metamizole sodium) + paracetamol (paracetamol) + phenobarbital (phenobarbital)

Producer: Pharmstandard-Leksredstva, JSC (Russia)

Description and photo update: 28.11.2018

Pentalgin-ICN is a combined preparation with antipyretic, analgesic and anti-migraine effects.

Release form and composition

Dosage form - tablets: from white with a cream or yellow tint to white, biconvex, in the form of a capsule with flat lateral surfaces, on one side of the risk, on the other - engraving "PENTALGIN" (in a cardboard box 1 or 2 blisters 6, 10 or 12 tablets and instructions for use of Pentalgin-ICN).

Active ingredients in 1 tablet:

• paracetamol - 300 mg;
• caffeine - 50 mg;
• metamizole sodium - 300 mg;
• codeine phosphate - 8 mg;
• phenobarbital - 10 mg.

Auxiliary components in Pentalgin-ICN: potato starch, povidone, stearic acid, calcium stearate.

Pharmacological properties

Pharmacodynamics

Pentalgin-ICN is one of the combined drugs that have antipyretic, analgesic and anti-migraine effects, due to the properties of the active components:

• paracetamol: is an antipyretic analgesic; blocks COX (cyclooxygenase) mainly in the central nervous system by acting on the centers of thermoregulation and pain; has analgesic and antipyretic properties;
• metamizole sodium: is a pyrazolone derivative, an analgesic-antipyretic; has a pronounced analgesic effect;
• caffeine: is a psychostimulant; reduces the severity of vascular headaches (including migraines) and improves well-being;
• phenobarbital: is a barbiturate; increases the analgesic effect of paracetamol and metamizole sodium;
• Codeine: has an analgesic effect, which is due to the excitation of opioid receptors in various parts of the central nervous system, which leads to a change in the emotional perception of pain and stimulation of the antinociceptive system.

Indications for use

• pain syndrome of weak / moderate intensity of various etiologies, including arthralgia, myalgia, sciatica, algodismenorrhea, neuralgia, headache / toothache;
• colds and conditions that are accompanied by a febrile syndrome.

Contraindications

Absolute:

• severe hepatic / renal impairment;
• deficiency of glucose-6-phosphate dehydrogenase;
• alcoholic intoxication;
• bronchial asthma;
• conditions that are accompanied by respiratory depression;
• leukopenia, anemia;
• acute myocardial infarction;
• cranial hypertension;
• glaucoma;
• arrhythmias;
• age up to 12 years;
• pregnancy and lactation;
• individual intolerance to the components in Pentalgin-ICN.

Relative (Pentalgin-ICN tablets are prescribed under medical supervision):

• arterial hypertension;
• peptic ulcer of the stomach and duodenum in remission;
• elderly age.

Pentalgin-ICN, instructions for use: method and dosage

Pentalgin-ICN tablets are taken orally 1 pc. 1 to 3 times a day, maximum 4 tablets a day.

Without supervision / prescription by a doctor, the drug as an antipyretic and anesthetic should not be used for more than 3 and 5 days, respectively.

Side effects

• cardiovascular system: tachycardia, palpitations;
• central nervous system: drowsiness, dizziness;
• hematopoietic system: granulocytopenia, leukopenia, agranulocytosis;
• digestive system: dyspeptic disorders in the form of vomiting, nausea, constipation;
• allergic reactions: itching, rash, urticaria;
• others (in the case of long-term uncontrolled intake of high doses): addiction (manifests itself as a weakening of the analgesic effect), hepatic / renal failure, drug dependence (to codeine).

Overdose

The main symptoms: gastralgia, vomiting, nausea, arrhythmia, tachycardia, depression of the respiratory center.

Therapy: measures aimed at reducing the absorption of active ingredients (in the form of gastric lavage, intake of intestinal adsorbents), if necessary, symptomatic treatment is carried out.

special instructions

Athletes may experience changes in doping control test results during therapy.

When carrying out long-term treatment (from 7 days), it is necessary to monitor the functional state of the liver and the picture of peripheral blood.

In acute abdominal pain syndrome, taking Pentalgin-ICN can make the diagnosis difficult.

The risk of developing hypersensitivity reactions is higher in patients with pollinosis and atopic bronchial asthma.

Influence on the ability to drive vehicles and complex mechanisms

During the use of Pentalgin-ICN, patients should refrain from driving and exercising that require quick psychomotor reactions and increased concentration of attention.

Application during pregnancy and lactation

Pentalgin-ICN is not prescribed during pregnancy / lactation.

Pediatric use

Pentalgin-ICN therapy is contraindicated in patients under 12 years of age.

With impaired renal function

Contraindication: severe renal failure.

For violations of liver function

Contraindication: severe hepatic impairment.

Use in the elderly

Pentalgin-ICN is prescribed with caution to elderly patients.

Drug interactions

• drugs that have a depressing effect on the central nervous system (including sedatives and tranquilizers): it is possible to increase the severity of the depressing effect on the respiratory center and the sedative effect;
• non-opioid analgesics: increased toxic effects;
• ethanol: the effect on the psychomotor reaction is enhanced;
• cyclosporine: its concentration decreases (due to metamizole sodium);
• indirect anticoagulants, oral hypoglycemic drugs, glucocorticosteroids, indomethacin: an increase in their activity (due to metamizole sodium);
• phenylbutazone, barbiturates and other inducers of microsomal liver enzymes: the effect of sodium metamizole is weakened;
• allopurinol, tricyclic antidepressants, oral contraceptives: the metabolism of metamizole sodium in the liver is disturbed and its toxicity increases.

Analogs

The analogues of Pentalgin-ICN are: Sedalgin-Neo, Pentalgin-MEZ, Sedal-M, Pentanov-ICN, Santoralgin.

Terms and conditions of storage

Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.

The shelf life is 3 years.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Pentalgin-ICN

Reviews about Pentalgin-ICN are mostly positive. In most cases, the drug effectively relieves pain of various etiologies. The rate of development of the analgesic effect has significant individual variability. Some patients indicate that in case of migraine and severe pain, Pentalgin-ICN is taken in combination with other drugs.

Price for Pentalgin-ICN in pharmacies

The approximate price for Pentalgin-ICN (12 tablets) is 170 rubles.

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!