Papaverine bufus
Papaverine bufus: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Use in the elderly
- 14. Drug interactions
- 15. Analogs
- 16. Terms and conditions of storage
- 17. Terms of dispensing from pharmacies
- 18. Reviews
- 19. Price in pharmacies
Latin name: Papaverin bufus
ATX code: A03AD01
Active ingredient: papaverine (Papaverine)
Producer: JSC PFC Obnovlenie (Russia)
Description and photo update: 2019-08-07
Prices in pharmacies: from 65 rubles.
Buy
Papaverine bufus is an antispasmodic drug.
Release form and composition
The drug is available in the form of a solution for intravenous (i / v) and intramuscular (i / m) administration: transparent liquid, slightly colored (2 ml in polymer ampoules, in a cardboard box of 10 or 100 ampoules and instructions for use of Papaverine bufus).
1 ml of solution contains:
- active substance: papaverine hydrochloride - 20 mg;
- auxiliary components: methionine, disodium edetate (Trilon B), water for injection.
Pharmacological properties
Pharmacodynamics
Papaverine bufus is an antispasmodic drug that has a vasodilator effect. Its active ingredient, papaverine, is an inhibitor of the phosphodiesterase enzyme. The mechanism of action of the drug is due to the ability of papaverine to cause intracellular accumulation of cyclic 3,5-adenosine monophosphate, which helps to reduce the tone of smooth muscles, impair their contractility and relaxation in spastic conditions.
On the central nervous system, therapeutic doses of the drug have a mild effect.
Against the background of high doses, there may be some sedation, a decrease in the excitability of the heart muscle, and a slowdown in intracardiac conduction.
Pharmacokinetics
The absorption of papaverine depends on the dosage form.
Bioavailability averages 54%, binding to blood plasma proteins - 90%. Papaverine is well distributed in the body, overcomes histohematogenous barriers. The drug metabolism occurs in the liver. T 1/2 (half-life) is 0.5–2 hours, it can be extended to 24 hours. It is excreted through the kidneys in the form of metabolites. It is completely removed from the blood during hemodialysis.
Indications for use
The use of Papaverine bufus is indicated as an auxiliary drug for premedication in spasms of peripheral vessels and cerebral vessels, smooth muscles of the abdominal organs, urinary tract and renal colic.
Contraindications
Absolute:
- violation of atrioventricular conduction;
- respiratory depression;
- coma;
- glaucoma;
- severe liver failure;
- period of pregnancy;
- breast-feeding;
- age up to 1 year;
- elderly age;
- hypersensitivity to the components of the drug.
With caution, papaverine bufus should be prescribed to patients with chronic renal failure, adrenal insufficiency, hypothyroidism, prostatic hyperplasia, supraventricular tachycardia, in shock and after traumatic brain injury.
Papaverine bufus, instructions for use: method and dosage
The solution is used by intravenous (slow) or intramuscular injection.
For intravenous administration, the drug solution should be diluted in 10–20 ml of isotonic sodium chloride solution; the procedure must be carried out in the presence of a doctor.
Recommended dosage:
- adults and adolescents over 12 years of age: a single dose - 20-40 mg (1-2 ml) with an interval between injections of at least 4 hours;
- children aged 1–12 years: the maximum single dose is at the rate of 0.3 mg per 1 kg of the child's weight.
Side effects
Possible adverse reactions from systems and organs:
- from the immune system: the development of allergic reactions;
- on the part of the vascular system: lowering blood pressure (BP);
- from the digestive system: nausea, constipation, increased activity of hepatic transaminases;
- from the blood system: eosinophilia;
- from the nervous system: drowsiness, headache;
- others: increased sweating; against the background of the use of high doses or rapid administration - a violation of the heart rhythm, the development of atrioventricular blockade.
Overdose
Symptoms: lowering blood pressure, diplopia, weakness, drowsiness.
Treatment: the appointment of symptomatic therapy, including taking measures to restore blood pressure.
special instructions
The use of alcoholic beverages during treatment is contraindicated.
Application during pregnancy and lactation
The safety of intravenous injections and intramuscular injections of Papaverine bufus during gestation and lactation has not been established, therefore, the administration of the drug to pregnant and lactating women is contraindicated.
Pediatric use
The use of the drug for the treatment of children under the age of 1 year is contraindicated.
With impaired renal function
Papaverine bufus should be used with caution in chronic renal failure.
For violations of liver function
Intravenous and intramuscular injections of Papaverine bufus are contraindicated in severe hepatic insufficiency.
Use in the elderly
Due to the risk of developing hyperthermia, the use of the drug for the treatment of elderly patients is contraindicated.
Drug interactions
- levodopa: its antiparkinsonian activity decreases;
- methyldopa: there is a decrease in its hypotensive effect;
- barbiturates: the antispasmodic effect of papaverine hydrochloride is enhanced;
- tricyclic antidepressants, novocainamide, reserpine, quinidine sulfate: an increase in the hypotensive effect is possible.
Analogs
Papaverine bufus analogs are: Papaverine, Papaverine hydrochloride, Papaverine hydrochloride MS, etc.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures from 15 to 25 ° C, protected from light.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about papaverine bufus
Reviews of Papaverine bufus are positive. Pointing to the effectiveness of the drug, patients note a quick antispasmodic effect, a long-lasting effect, no side effects, and an affordable price.
The price of Papaverine bufus in pharmacies
The price of Papaverine bufus for a pack containing 10 ampoules can be 36–62 rubles.
Papaverine bufus: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Papaverine bufus 20 mg / ml solution for intravenous and intramuscular administration 2 ml 10 pcs. RUB 65 Buy |
|
Papaverine bufus 20 mg / ml solution for intravenous and intramuscular administration 2 ml 100 pcs. 238 r Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
