Ksarelto - Instructions For Use, Analogues, Reviews

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Xarelto

Instructions for use:

1. 1. Pharmacological action and pharmacodynamics
2. 2. Pharmacokinetics
3. 3. Indications for use
4. 4. Contraindications to use
5. 5. Side effects
6. 6. Doses and method of administration
7. 7. Analogs

Prices in online pharmacies:

from 1471 rub.

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Xarelto is a direct-acting anticoagulant. It is produced in the form of film-coated tablets with an active substance content of 10, 15 and 20 milligrams. The active ingredient is micronized rivaroxaban.

Pharmacological action and pharmacodynamics

According to the instructions, Xarelto inhibits factor Xa, and also has an anticoagulant effect.

The mechanism of action of Xarelto according to the instructions is the direct inhibition of factor Xa. Rivaroxaban is highly selective and has a high bioavailability (80-100 percent) when taken orally. Activation through the external and internal coagulation pathways of factor X to form factor Xa plays the most important role in the coagulation cascade.

Pharmacokinetics

Rivaroxaban is rapidly absorbed - the maximum concentration in the blood is reached within two to four hours after taking the pill. After entering the body, most of rivaroxaban (92 to 95 percent) binds to plasma proteins, the main binding component is serum albumin.

When taken orally, approximately two-thirds of the dose of rivaroxaban is metabolized and subsequently excreted in equal parts along with feces and urine. The remaining third is excreted unchanged by direct renal excretion, primarily due to active renal secretion.

Indications for use of Ksarelto

According to the instructions, Xarelto in the form of 10 milligram tablets is indicated for the prevention of venous thromboembolism in people who have undergone major orthopedic surgery on the lower extremities.

Xarelto tablets of 15 and 20 milligrams are indicated for the prevention of systemic thromboembolism and stroke in people with non-valvular atrial fibrillation, as well as for the treatment of pulmonary embolism and deep vein thrombosis, for the prevention of recurrent PE and DVT.

Contraindications to the use of Ksarelto

According to the instructions, Ksarelto is contraindicated for:

• Hypersensitivity to the active substance (rivaroxaban) or any other substances contained in the tablets;
• Intracranial, gastrointestinal, or other bleeding;
• Concomitant treatment with any other anticoagulants;
• Conditions in which there is a high risk of major bleeding;
• Pregnancy and lactation period;
• Liver diseases in which coagulopathy is observed;
• Under the age of eighteen;
• Severe renal failure;
• Hereditary galactose or lactose intolerance.

Xarelto side effects

Reviews of Xarelto indicate that the use of Xarelto tablets may be accompanied by the risk of overt or latent bleeding from any tissues or organs, which can lead to posthemorrhagic anemia. Also, according to reviews, Xarelto can cause hemorrhagic complications: weakness, dizziness, pallor, shortness of breath, headache, an increase in limb volume or shock.

Doses and method of administration of Ksarelto

Xarelto tablets of 10 milligrams are taken regardless of meals, 15 and 20 milligrams - during meals.

After major operations on the knee joint, the duration of treatment is two weeks, after major operations on the hip joint - five weeks. The initial dose is taken six to ten hours after the operation in the event that hemostasis is achieved. The therapeutic dose is one tablet per day.

If you miss a dose, you should immediately take the Xarelto tablet and continue to take the drug regularly the next day, according to the recommendations. To compensate for the missed dose, it is prohibited to double the dose taken.

Analogs of Ksarelto

The analogue of Xarelto is Rivaroxaban.

Ksarelto: prices in online pharmacies

Drug name Price Pharmacy

Xarelto 15 mg film-coated tablets 14 pcs. 1471 RUB Buy

Xarelto 2.5 mg film-coated tablets 28 pcs. 1635 RUB Buy

Xarelto 20 mg film-coated tablets 14 pcs. 1671 RUB Buy

Xarelto 20 mg film-coated tablets 28 pcs. 2890 RUB Buy

Xarelto 15 mg film-coated tablets 28 pcs. 2900 RUB Buy

Xarelto 2.5 mg film-coated tablets 56 pcs. 3269 RUB Buy

Xarelto tablets p.p. 15mg 28 Pcs. 3287 RUB Buy

Xarelto tablets p.p. 20mg 28 pcs. 3293 RUB Buy

Xarelto 10 mg film-coated tablets 30 pcs. 3336 RUB Buy

Xarelto tablets p.p. 2.5mg 56 pcs. 3535 RUB Buy

Xarelto 10 mg film-coated tablets 100 pcs. RUB 9540 Buy

Xarelto 15 mg film-coated tablets 100 pcs. RUB 9655 Buy

Xarelto 20 mg film-coated tablets 100 pcs. 11777 RUB Buy

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Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!