Dikain
Dikain: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacodynamics and pharmacokinetics
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application in children
- 10. Pregnancy and lactation period
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Dicain
ATX code: S01HA03
Active ingredient: Tetracaine (Tetracaine)
Manufacturer: BioL (Russia)
Description and photo update: 2019-06-08
Dikain (Dikaina (beta form) solution 0.3% (eye drops)) is a local anesthetic drug used in ophthalmology.
Release form and composition
Dosage form - eye drops: slightly colored or colorless, transparent or slightly opalescent solution (in vials of 5 (with a dropper) or 10 ml, 1 bottle in a cardboard box).
The preparation contains leocaine, sodium chloride, purified water.
Pharmacodynamics and pharmacokinetics
Dikain is a local anesthetic used for surface anesthesia. The substance blocks sodium channels, preventing impulses from arising in sensitive nerve endings and their conduction in nerve tissues.
The drug takes effect 30–90 seconds after application to the mucous membranes. The duration of the action is 20 minutes.
The Dikain solution is rapidly and almost completely absorbed through the mucous membranes. The rate of absorption is determined by the dosage of the drug. The degree of its binding to plasma proteins is quite high. The substance is completely hydrolyzed in plasma with the participation of cholinesterase for 1.5 hours, forming PABA-containing compounds. In the same way, dicaine is partially metabolized in the liver and excreted mainly in the bile and through the kidneys, partially being recirculated in the intestines and liver.
Indications for use
Dikain is prescribed to adults for pain relief during short-term surgical interventions on the anterior segment of the eyeball.
Contraindications
A contraindication to the use of the drug is the presence of hypersensitivity to its components.
Instructions for the use of Dikain: method and dosage
Dikain is used as instillations of 1-2 drops immediately before surgery. If necessary, during the operation (depending on the patient's condition and the duration of the operation), you can additionally instill 1-2 drops.
Side effects
After using Dikain, it is possible to develop a short-term burning sensation and mild allergic reactions.
Overdose
Overdose symptoms are:
- agitation and anxiety;
- muscle tremor;
- convulsive activity;
- dizziness;
- general weakness;
- nausea and vomiting;
- breathing disorder;
- collapse;
- coma;
- AV block;
- methemoglobinemia.
When these signs appear, the drug is immediately removed from the skin and mucous membranes. When the respiratory center is inhibited, oxygen therapy and mechanical ventilation are recommended. With convulsive activity, barbiturates or diazepam are used. In case of collapse, vasoconstrictors and blood substitutes (dextran preparations, saline solutions, hemodesis) are injected intravenously. In the case of methemoglobinemia, methylene blue is injected intravenously at a dose of 1–2 mg / kg, or oral vitamin C is prescribed in an amount of 100–200 mg.
special instructions
Dikain does not aggravate the course of pathological processes.
Application in children
According to the instructions, Dikain is not recommended for use in the treatment of children under 10 years of age.
Pregnancy and lactation
The use of Dikain during these periods is allowed only in exceptional cases as prescribed by a doctor and in the presence of strict indications.
Drug interactions
There are no data on the interaction of the Dikain solution with other drugs.
Analogs
Dikain's analogs are: Novocaine, Ultracaine, Lidocaine, Anestezin, Felikaine, Anetaine, Decicaine, Ametokaine, Intercaine, Medikaine, Rexocaine, Pantokaine, Foncaine.
Terms and conditions of storage
Store in a cool place out of reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Dikain
According to reviews, Dikain is practically not used by medical professionals in practice due to its high toxicity and the development of safer and more inexpensive analogues. If it is necessary to prescribe a drug, the doctor must write a prescription.
Price for Dikain in pharmacies
The price of Dikain is unknown, since the drug is not on sale due to its toxic effects on the body and the development of more effective and affordable analogues.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
