Etrivex - Instructions For The Use Of Shampoo, Reviews, Price, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Etrivex

Etrivex: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. Drug interactions
12. 12. Analogs
13. 13. Terms and conditions of storage
14. 14. Terms of dispensing from pharmacies
15. 15. Reviews
16. 16. Price in pharmacies

Latin name: Etrivex

ATX code: D07AB01

Active ingredient: Clobetasol (Clobetasol)

Producer: Laboratoires Galderma (France)

Description and photo update: 2018-26-10

Prices in pharmacies: from 890 rubles.

Buy

Etrivex is a topical glucocorticosteroid (GCS).

Release form and composition

The dosage form of Etrivex is 0.05% shampoo: a viscous translucent liquid from colorless to slightly yellow in color with the smell of alcohol (30, 60 and 125 ml in polyethylene bottles, each bottle is packed in a cardboard box).

Composition of 1 g of shampoo:

• active substance: clobetasol propionate - 500 mcg;
• additional components: sodium citrate, sodium lauryl sulfate, citric acid monohydrate, cocobetaine, ethanol 96%, polyquaternium, purified water.

Pharmacological properties

Pharmacodynamics

Clobetasol is a glucocorticosteroid that has anti-inflammatory, vasoconstrictor and antipruritic effects.

The mechanism of anti-inflammatory activity is not fully understood, but it is believed that GCS act by inducing lipocortin proteins, which inhibit phospholipase A ₂. This process suppresses the release of arachidonic acid, which is a precursor to powerful inflammatory mediators such as leukotrienes and prostaglandins.

Thus, due to the induction of lipocortins, clobetasol reduces the biosynthesis of the main inflammatory mediators, and, therefore, has anti-inflammatory properties.

Pharmacokinetics

Clobetasol is characterized by low systemic absorption when applied externally, so the likelihood of developing systemic effects during treatment with Etrivex is extremely low. However, the risk of systemic actions is possible when the drug is applied to large areas of the body, especially with impaired skin integrity or skin inflammation.

Clobetasol is metabolized mainly in the liver, to a lesser extent in the kidneys.

It is excreted by the kidneys.

Indications for use

According to the instructions, Etrivex is intended for the treatment and prevention of recurrence of psoriasis of the scalp, with the exception of extensive plaque and pustular psoriasis.

Contraindications

• bacterial, viral, fungal and parasitic infections of the skin;
• violation of the integrity of the skin at the intended site of shampoo application (for example, skin ulceration, wounds, etc.);
• age up to 18 years;
• pregnancy and lactation;
• hypersensitivity to any component of Etrivex.

Instructions for the use of Etrivex: method and dosage

Etrivex shampoo is applied externally only on the scalp.

For medicinal purposes, the shampoo should be applied daily: applied to dry scalp, rubbing thoroughly into the affected areas. Regardless of the number of affected areas, approximately 7.5 ml of shampoo (½ tablespoon) is sufficient for one application. The applied product is left on for 15 minutes, and then washed off with water and washed with regular shampoo. Do not cover your head to enhance the effect of the drug.

The duration of treatment is determined individually, but does not exceed 4 weeks.

After the lesions have cleared, or a small amount of psoriatic scales remains after a 4-week course, shampoo is used 2 times a week to maintain the therapeutic effect and prevent relapses. Maintenance therapy is effective for 6 months.

To prevent exacerbations, repeated treatment courses are carried out using Etrivex shampoo daily. Therapy should be carried out under the supervision of a physician.

Side effects

Etrivex shampoo is generally well tolerated. In some cases (0.1-1%), the following side effects occur:

• from the nervous system: headache;
• on the part of the organ of vision (in case of accidental contact with the eyes): eye irritation;
• on the part of the skin and subcutaneous fat: acne (where the drug is applied), allergic contact dermatitis, skin tightening, folliculitis, discomfort, soreness and swelling of the skin, dryness and irritation of the skin, urticaria, itching, telangiectasia, rash, erythema, exacerbation of psoriasis, alopecia, skin atrophy.

With prolonged daily use of Etrivex, application of shampoo in large quantities and / or on large areas of the body, systemic absorption of clobetasol is possible and, as a consequence, the development of hypercortisolism (Cushing's syndrome) or suppression of the hypothalamic-pituitary-adrenal system, which wears a short-term (transient) and quickly reversible. However, if you follow the recommendations for the use of the drug (apply shampoo for 15 minutes), then systemic absorption is possible only in rare cases.

Intensive and / or prolonged treatment with powerful glucocorticosteroids can lead to local skin atrophy, contact dermatitis, purpura, erythema, telangiectasia, striae. In case of contact with the skin of the face, exacerbation of rosacea, development of perioral dermatitis or skin atrophy is possible.

There are separate reports of the occurrence of pustular rashes and acne, the development of hypertrichosis and changes in pigmentation with the external use of powerful glucocorticosteroids.

Overdose

The development of symptoms of an acute overdose is unlikely, however, if the recommended doses are constantly exceeded or if Etrivex is used incorrectly, signs of hypercortisolism may occur. In this case, the drug is gradually canceled. Due to the risk of suppression of adrenal function, the patient should be under close medical supervision.

special instructions

Like other GCS for external use, clobetasol should be used with caution, including because of the recurrence of the disease after the end of the course of treatment, due to the development of resistance, local and systemic toxicity.

In rare cases, with intensive or prolonged use of GCS, or after their cancellation, an outbreak of generalized pustular psoriasis occurs.

Hypersensitivity reactions to glucocorticosteroids are very rare. The likelihood of their occurrence should be assumed in patients refractory to therapy.

In general, long-term continuous treatment with daily use of GCS, as well as the use of occlusive dressings, is associated with the risk of developing systemic effects. In this case, careful medical supervision and regular examinations of the patient are required in order to identify in time possible suppression of the hypothalamic-pituitary system. Systemic effects usually subside after discontinuation of therapy. However, the withdrawal of the drug should be carried out gradually, since with a sharp withdrawal, the development of acute adrenal insufficiency is possible.

Etrivex Shampoo is intended for use on the scalp only. It should not be applied to other parts of the body, including the face and eyelids, eroded areas of the body, and areas of folded skin (armpits, genital and anal areas), as the risk of unwanted local reactions such as dermatitis increases., telangiectasia and atrophic skin changes.

If shampoo gets in your eyes, rinse immediately with plenty of clean water, as there is a risk of developing cataracts and glaucoma.

Etrivex is recommended for short-term treatment. Repeated short courses can be carried out if necessary.

Influence on the ability to drive vehicles and complex mechanisms

When applied externally, clobetasol does not adversely affect the patient's ability to concentrate, the speed of his mental and physical reactions.

Application during pregnancy and lactation

Etrivex is contraindicated during pregnancy and lactation.

Pediatric use

Etrivex should not be used to treat children and adolescents under 18 years of age.

Drug interactions

Cases of interaction of clobetasol with its external use simultaneously with other drugs are unknown.

Analogs

The analogues of Etrivex are: Dermovate, Cloveit, Powercourt.

Terms and conditions of storage

Shelf life is no more than 3 years.

Keep out of the reach of children. Do not exceed a temperature of 25 ° C.

Terms of dispensing from pharmacies

Dispensed by prescription.

Reviews about Etrivex

Reviews about Etrivex are mostly positive. Patients confirm the high efficacy of the drug in the treatment of scalp psoriasis.

Additional advantages include the form of release - shampoo, short duration of applications - only 15 minutes, quick action - aggravation, according to reviews, can be removed in just 1 week, and improvement in the condition is noted even after a single use of shampoo, as well as the duration of action, i.e. long-term absence of relapses.

The price of Etrivex in pharmacies

The approximate price for Etrivex is 855-930 rubles for a 60 ml bottle.

Etrivex: prices in online pharmacies

Drug name Price Pharmacy

Etrivex 0.05% shampoo 60 ml 1 pc. 890 RUB Buy

Etrivex shampoo 0.05% 60 ml 1050 RUB Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!