Ergoferon
Ergoferon: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Ergoferon
ATX code: J05AX, R06A
Active ingredient: affinity purified antibodies to human gamma-interferon, histamine and CD4 gene
Producer: Materia Medica Holding NPF LLC (Russia)
Description and photo updated: 2018-23-11
Prices in pharmacies: from 329 rubles.
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Ergoferon - homeopathic combined immunomodulatory drug; possesses antiviral, antihistamine, anti-inflammatory activity.
Release form and composition
Dosage forms:
- lozenges: from almost white to white, flat-cylindrical, with a bevel, on one side there is an inscription ERGOFERON, on the other - a dividing line and the inscription MATERIA MEDICA (20 pcs. in blisters, in a cardboard box 1, 2 or 5 packages);
- oral solution: a transparent, almost colorless or colorless liquid (100 ml in an orange glass bottle with a dropper, in a cardboard box 1 bottle).
1 tablet contains:
- active ingredients: antibodies to human gamma-interferon affinity purified - 0.006 g (in water-alcohol dilution 100 12), antibodies to histamine affinity purified - 0.006 g (in water-alcohol dilution 100 30), antibodies to the CD4 gene affinity purified - 0.006 g (in water-alcohol dilution 100 50);
- auxiliary components: microcrystalline cellulose, lactose monohydrate, magnesium stearate.
100 ml of oral solution contains:
- active ingredients: antibodies to human gamma-interferon affinity purified - 0.12 g (in water-alcohol dilution 100 12); antibodies to histamine affinity purified - 0.12 g (in water-alcohol dilution 100 30), antibodies to the CD4 gene affinity purified - 0.12 g (in water-alcohol dilution 100 50);
- auxiliary components: potassium sorbate, maltitol, anhydrous citric acid, glycerol, purified water.
Pharmacological properties
Pharmacodynamics
Ergoferon is an immunomodulating drug with antiviral, anti-inflammatory and antihistamine activity. A wide range of pharmacological action is due to its combined composition. All active components of the drug have the same mechanism of action, which consists in increasing the functional activity of the CD4 receptor, receptors for interferon gamma and histamine. This contributes to the pronounced immunotropic effect of Ergoferon.
Thanks to the combination of three active components, their immunomodulatory activity is enhanced:
- antibodies to interferon gamma: increasing the expression of alpha-, beta- and gamma-interferon and interleukins (IL) coupled to them - IL-2, IL-4, IL-10, normalize the level and functional activity of natural antibodies to interferon gamma, which are an essential factor in the body's natural antiviral resistance. The presence of antibodies to interferon gamma in Ergoferon helps to improve the ligand-receptor interaction of interferons and restore the cytokine status. It potentiates the induction of the expression of antigens of the main histocompatibility complex of types I, II, Fc receptors, monocytes, stimulates the regulation of immunoglobulin synthesis, the functional activity of NK cells (natural killer cells), activates the immune response of T-helper types 1 and 2 (Th1 and Th2);
- antibodies to histamine: by modifying the histamine-dependent activation of H1-receptors, they contribute to a decrease in the tone of bronchial smooth muscles, capillary permeability. This effect reduces the duration and severity of swelling of the nasal mucosa, rhinorrhea, coughing and sneezing. At the same time, the severity of concomitant allergic reactions decreases, the chemotaxis of eosinophils and platelet aggregation in reactions to contact with an allergen decrease;
- antibodies to CD4: regulating the functional activity of the CD4 receptor, they cause an increase in the functional activity of CD4 lymphocytes, normalization of the CD4 / CD8 immunoregulatory index, the composition of subpopulations of immunocompetent cells - CD3, CD4, CD8, CD16 and CD20.
The experimentally established efficacy of the drug components is confirmed by data from clinical studies obtained in the treatment of the following infectious diseases: acute respiratory pathologies (caused by adenoviruses, parainfluenza viruses, respiratory syncytial viruses and coronaviruses), influenza A and B viruses, chicken pox, labial herpes, ophthalmic herpes, herpes zoster herpes, genital herpes, infectious mononucleosis, meningitis (enterovirus, meningococcal), tick-borne encephalitis, acute intestinal infections (caused by rotaviruses, enteroviruses, caliciviruses and coronaviruses), hemorrhagic fever with renal syndrome.
The use in the complex therapy of bacterial infections (including pneumonia of various etiologies, including those caused by atypical pathogens - Chlamydophila pneumoniae, Mycoplasma pneumoniae, Legionella speciales), pseudotuberculosis, yersiniosis, whooping cough, in addition to the therapeutic effect, allows to prevent the development of superinfections. The drug is effective in the prevention of bacterial complications of viral lesions; increases the effectiveness of vaccination when taken in the pre- and post-vaccination period. At the stage of post-vaccination immunity formation, it provides non-specific prophylaxis of influenza and acute respiratory viral infections (ARVI). It has a preventive effect against ARVI of non-influenza etiology, prevents the development of intercurrent diseases after vaccination.
Pharmacokinetics
It is technically impossible to study the pharmacokinetics of Ergoferon due to the insufficient sensitivity of modern physicochemical methods of analysis (gas-liquid chromatography, high-performance liquid chromatography, chromatography-mass spectrometry), which does not allow a reliable assessment of the content of active components of the drug in tissues, organs and biological fluids of a person.
Indications for use
According to the instructions, Ergoferon is recommended for the prevention and treatment of the following diseases:
- influenza virus type A and B;
- acute respiratory viral infections caused by adenovirus, parainfluenza virus, coronavirus, respiratory syncytial virus;
- herpesvirus infections (chickenpox, ophthalmic herpes, labial herpes, herpes zoster, genital herpes, infectious mononucleosis);
- acute intestinal infections caused by adenovirus, calicivirus, coronavirus, enterovirus, rotavirus;
- meningitis (enterovirus and meningococcal);
- hemorrhagic fever with renal syndrome;
- tick-borne viral encephalitis.
In addition, the drug is prescribed as part of the complex therapy of whooping cough, pseudotuberculosis, pneumonia of various etiologies (including Mycoplasma pneumoniae, Chlamydia pneumoniae, Legionella speciales), and bacterial yersiniosis. And also for the prevention of superinfections and the prevention of bacterial complications of viral infections.
Contraindications
The use of Ergoferon is contraindicated in patients with hypersensitivity to its components.
The drug should be prescribed with caution during pregnancy and breastfeeding.
Additional contraindications:
- tablets: congenital galactosemia or lactase deficiency, glucose-galactose malabsorption syndrome;
- solution: hereditary fructose intolerance, age up to 3 years.
The solution must be taken with caution in patients with diabetes mellitus.
Instructions for the use of Ergoferon: method and dosage
Lozenges
The tablets are taken orally, without swallowing immediately, but holding in the mouth until they are completely dissolved. The drug should be taken some time after eating.
It is recommended to pre-dissolve Ergoferon tablet for children aged from six months to three years in 1 tablespoon of boiled water cooled to room temperature.
Recommended dosage of Ergoferon:
- acute infections: 7 pcs. during the first day according to the scheme - 1 pc. every 0.5 hours during the first 2 hours, then 1 pc. at an interval of 7 hours. Treatment is continued at a dose of 1 pc. 3 times a day. The drug should be used until complete recovery;
- prevention of viral infectious diseases: 1-2 pcs. in a day. The duration of the course is determined by the doctor individually, it can be from 30 to 180 days.
Oral solution
The solution is taken orally, swallowing not immediately, but keeping it in the mouth for a while, this will ensure the maximum effect of the drug. Solution intake should not be combined with food intake.
Recommended dosage of Ergoferon:
- acute infections: during the first day according to the scheme - 5 ml (1 teaspoon) 4 times every 0.5 hours, then 5 ml every 7 hours (3 times). From the second day onwards, treatment is continued at a dose of 5 ml 3 times a day. The solution should be applied until complete recovery;
- prevention of viral infectious diseases: 5-10 ml per day, the duration of the course is determined by the doctor individually, it can be from 30 to 180 days.
It is necessary to start treatment of an acute infection from the moment its first symptoms appear.
Side effects
Taking Ergoferon can cause the development of hypersensitivity reactions.
Overdose
Symptoms of an overdose of Ergoferon are dyspeptic symptoms in the form of nausea, vomiting and / or diarrhea. When they appear, symptomatic therapy is recommended.
special instructions
In case of signs of side effects of Ergoferon, you should consult a doctor.
The content of maltitol in 5 ml of the solution is 0.3 g, which corresponds to 0.02 XE (bread unit). For the metabolism of maltitol in diabetes mellitus, it is necessary to consider adjusting the dose of insulin. When prescribing a dose of insulin, one should take into account the slow hydrolysis and absorption of the drug in the gastrointestinal tract. Energy value of 5 ml of solution - 1.37 kcal. The energy value of maltitol is much lower than that of sucrose and amounts to 2.4 kcal / g.
Influence on the ability to drive vehicles and complex mechanisms
Taking Ergoferon tablets does not affect the patient's ability to drive vehicles and mechanisms. The effect of the solution on the psychophysical state of patients has not been studied.
Application during pregnancy and lactation
There is no information about the safety of Ergoferon use during gestation and lactation.
It is recommended to resort to prescribing the drug during pregnancy and breastfeeding, only in cases where, in the opinion of the attending physician, the expected effect of therapy for the mother exceeds the potential threat to the fetus or child.
Pediatric use
The appointment of Ergoferon is contraindicated for children under the age of six months - in the form of tablets, for children under three years old - in the form of a solution.
Drug interactions
Reception of Ergoferon can be combined with drugs for symptomatic therapy and other antiviral drugs, cases of incompatibility have not been established.
Analogs
Ergoferon analogs are: Alpizarin, Allokin-alpha, Arbidol, Viferon, Hyporamine, Oscillococcinum, Celsentri, Ingavirin, Viracept, Kagocel, Fuzeon, Nikavir, Tiloron, etc.
Terms and conditions of storage
Keep out of the reach of children.
Store at temperatures up to 25 ° C in a dark place.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Ergoferon
Reviews about Ergoferon are quite contradictory. Patients who started taking the drug when the first symptoms of influenza appear, in strict accordance with the scheme indicated in the instructions, notice a tangible relief of the condition already on the second day of therapy. Preventive use of a homeopathic remedy by family members where there is a patient with a viral infectious disease allows them to avoid infection. Many patients, after repeated use of the drug for diseases of viral etiology, report that therapy allows them to more easily endure the acute period of the disease and helps to accelerate the healing process.
In reviews with a negative assessment of Ergoferon, it is said about the complete absence of a therapeutic effect, and in some cases even about the aggravation of the course of the disease.
The price of Ergoferon in pharmacies
The price of Ergoferon for a pack containing 20 tablets can range from 319 rubles.
Ergoferon: prices in online pharmacies
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Drug name Price Pharmacy |
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Ergoferon tablets for resorption 20 pcs. 329 r Buy |
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Ergoferon tab. d / rassas n20 338 r Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
