Exorolfinlac
Exorolfinlac: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Exorolfinlak
ATX code: D01AE16
Active ingredient: amorolfine (amorolfine)
Producer: Sandoz, dd (Slovenia), Paul W. Beyvers (Germany), CJSC Sandoz (Russia)
Description and photo update: 2018-25-10
Prices in pharmacies: from 545 rubles.
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Exorolfinlac is an antifungal drug for external use.
Release form and composition
Dosage form of Exorolfinlac - nail polish: thick, colorless transparent liquid (2.5 or 5 ml in dark glass bottles, the set includes 30 napkins, 10 special spatulas and 30 disposable nail files; 1 set in a cardboard box).
Composition for 1 ml of varnish:
- active ingredient: amorolfine - 50 mg (in the form of amorolfine hydrochloride - 55.74 mg);
- auxiliary ingredients: ethyl acetate - 150 mg; triacetin - 10.5 mg; Eudragit RL PO (methacrylic acid copolymer) - 125 mg; butyl acetate - 50 mg; ethanol - 480 mg.
Pharmacological properties
Pharmacodynamics
The active component of Exorolfinlac - amorolfine - ensures its fungistatic and fungicidal efficacy due to the destruction of the cytoplasmic fungal membrane by disrupting the biosynthesis of sterols, thereby reducing the level of ergosterol and accumulating atypical stereoisomers - steric non-planar sterols.
Due to its broad spectrum of action, amorolfine is highly active against not only the most common, but also rare fungal pathogens that affect the nail plate:
- dermatophytes: Microsporum spp., Trichophyton spp., Epidermophyton spp.;
- yeast fungi: Candida spp., Malassezia spp. (Pityrosporum spp.), Cryptococcus spp.;
- molds: Scopulariopsis spp., Alternaria spp., Hendersonula spp.;
- fungi of the Dematiaceae family: Fonsecaea spp., Cladosporium spp., Wangiella spp.;
- dimorphic fungi: Histoplasma spp., Coccidioides spp., Sporothrix spp.
Pharmacokinetics
After applying varnish to the nails in the nail plate and further into the nail bed, amorolfine penetrates almost completely during the first 24 hours. The effective concentration of the substance remains in the affected areas from 7 to 10 days even after the first application. The substance undergoes systemic absorption insignificantly, its plasma concentration is below the sensitivity limit of the determination methods (<0.5 ng / ml).
Indications for use
According to the instructions, Exorolfinlac is recommended for the local treatment of fungal infections of the nail plates caused by yeasts, dermatophytes and molds. The drug is also used to prevent fungal infections of the nails.
Contraindications
- pregnancy and lactation;
- children and adolescents under 18 years of age;
- hypersensitivity to amorolfine and other components of the drug.
Instructions for use of Exorolfinlac: method and dosage
Exorolfinlac is intended for external application to the affected nail plates of the fingers and / or toes.
The procedure is performed 1-2 times a week, observing the following recommendations:
- Before using the drug, using the disposable nail file included in the kit, if possible, remove the affected fragments of the nail, especially from its surface.
- The surface of the nail is cleaned and degreased with a special cleaning cloth from the set (for each subsequent use, the procedure for treating the affected nails with a nail file is repeated, after which the remaining layer of varnish is removed with a cleaning cloth).
- An applicator is immersed in a bottle of varnish, then it is carefully removed, without erasing the excess of the drug on the neck of the bottle.
- With the applicator, varnish is applied to the entire surface of the affected nail plate in an even layer, repeating the procedure for each affected nail.
- Allow the varnish to dry for about 3 minutes.
- The applicator is wiped with the tissue used for cleaning nails, avoiding contact with the treated nails. The bottle is tightly closed immediately after the end of the procedure. The used napkin is discarded.
It is allowed to apply decorative nail polish on top of Exorolfinlak, but not earlier than 10 minutes after the procedure.
Before re-using the drug Exorolfinlac, the remaining decorative varnish from the nails must be carefully removed, then, using the supplied files, treat the affected nail plates and remove the remaining varnish with cleaning napkins.
You should wash your hands thoroughly after each treatment procedure, but when applying the drug to your fingernails, you must first wait until the varnish has completely dried. After the varnish is completely dry, you can regularly wash your hands and feet using soap.
The course of therapy is long, the use of Exorolfinlac should be discontinued after complete regeneration of the nail plate and healing of the affected nails. The average duration of a course for fingernails is 6 months, for toenails - 9-12 months.
Since the nail plates grow slowly, the first signs of improvement are noticeable only after 2-3 months of systematic use of the drug. In the absence of such signs after 3 months, you need to consult a doctor.
Side effects
The use of the drug Exorolfinlac causes unwanted reactions in rare cases. Damage to the nails noted during treatment (destruction of the nail plates, discoloration and brittle nails) are most likely the result of a fungal infection.
The frequency of adverse reactions recorded during the use of Exorolfinlac in accordance with the accepted systemic organ classification (in accordance with the scale: very often - more than 0.1; often - not more than 0.01, but less than 0.1; infrequently - not more than 0.001, but less than 0.01; rarely - not more than 0.0001, but less than 0.001; extremely rarely - less than 0.0001; unclear frequency - it is impossible to quantify adverse reactions based on the available data):
- skin and subcutaneous tissues: rarely - discoloration of the nail plate, damage to nails, fragility of the nail plate (onychoclasia), fragility of the nail plate (onychorexis); extremely rare - a burning sensation of the skin; unexplained frequency - urticaria, pruritus, erythema, contact dermatitis, blisters;
- immune system: unclear frequency - systemic hypersensitivity reactions.
If any of these side effects aggravate or if other negative reactions are not indicated in the description, you should immediately consult a doctor.
Overdose
The drug is used exclusively for external use, in which the development of systemic signs of overdose is not expected.
If Exorolfinlac is accidentally swallowed, appropriate symptomatic treatment is required.
special instructions
When treating with Exorolfinlac it is necessary:
- The files used to treat the affected nails should not be used for the purpose of treating healthy nail plates.
- Wear impervious gloves when working with organic solvents to protect coated nails.
- Avoid using artificial false nails.
- Do not apply the varnish too often or in violation of the application requirements, as this can lead to irritation / dryness of the skin around the nail due to the presence of ethanol in the preparation.
- Please note that the cleaning cloth contains a flammable substance.
- Avoid getting the drug in ears, eyes, on mucous membranes, and in case of unintentional contact, immediately rinse the affected surfaces with plenty of running water.
In case of systemic / local hypersensitivity reactions, the use of the drug is immediately stopped and a doctor is consulted, having previously removed the drug from the nails using a nail polish remover. In this case, Exorolfinlac cannot be reapplied.
Conditions predisposing to the development of fungal diseases of the nails, such as diabetes mellitus, impaired peripheral circulation, immunodeficiencies, as well as dystrophy of the nail or a destroyed nail plate, psoriasis, and other chronic skin diseases, require a visit to a specialist.
When more than 2/3 of the nail plate is destroyed or affected by the fungus, it is also necessary to consult a doctor for prescribing oral medications for the purpose of complex therapy.
Influence on the ability to drive vehicles and complex mechanisms
Has not been studied.
Application during pregnancy and lactation
Data on the use of amorolfine during pregnancy and during breastfeeding are limited, and therefore the use of Exorolfinlac during these periods is not recommended.
Pediatric use
In pediatrics, there is no data on the safety and effectiveness of the use of amorolfine for the treatment of children and adolescents under 18 years of age, therefore, Exorolfinlac should not be prescribed to patients of this age group.
Drug interactions
Has not been studied.
Analogs
Exorolfinlac analogs are Lotseril, Onihelp, Oflomil varnish.
Terms and conditions of storage
Store in a place protected from light, out of the reach of children, at temperatures up to 25 ° C. Once opened, the bottle should be used within 6 months.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews about Exorolfinlac
In the few reviews about Exorolfinlac, patients are advised to follow the dosing regimen to increase the effectiveness of the drug, using varnish regularly and for a long time.
As the advantages of this drug in comparison with its analogues, it is noted that it should be applied only 2 times a week, and also that the bottle of varnish is equipped with all the tools and materials necessary for manipulation. The cost of a drug is defined as democratic.
A big plus is that a decorative varnish coating can be applied over the Exorolfinlac layer, which masks the disease of the nail plates.
Price for Exorolfinlac in pharmacies
The approximate price for Exorolfinlac (5% nail polish, 2.5 ml bottle) is about 900-1150 rubles.
Exorolfinlac: prices in online pharmacies
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Drug name Price Pharmacy |
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Exorolfinlac 5% nail polish 2.5 ml 1 pc. RUB 545 Buy |
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Exorolfinlac nail polish 5% fl. 2,5 ml (with spatulas 10 pcs. Cleaning cloth. 30 pcs. Files. 30 pcs.) 888 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
