Chondroitin-VERTEX
Chondroitin-VERTEX: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Chondroitin-VERTEX
ATX code: M01AX25
Active ingredient: chondroitin sulfate (Chondroitin sulfate)
Manufacturer: JSC "VERTEX" (Russia)
Description and photo update: 2020-30-03
Chondroitin-VERTEX is a tissue repair stimulator.
Release form and composition
Dosage form - gel for external use 5%: transparent, colorless or light yellow, has a specific odor, can become opalescent and contain air bubbles (in an individual cardboard package, instructions for use of Chondroitin-VERTEX and 1 aluminum tube containing 30 or 50 g of gel).
Composition of the preparation per 1 g:
- active substance: chondroitin sulfate (in the form of chondroitin sodium sulfate) - 50 mg;
- auxiliary components: purified water, disodium edetate, carbomer, propylene glycol, macrogol glyceryl hydroxystearate, trolamine (triethanolamine), dimethyl sulfoxide, methyl parahydroxybenzoate (methylparaben), orange blossom oil (neroli), lavender oil.
Pharmacological properties
Pharmacodynamics
The active ingredient of the drug - chondroitin sulfate - is a high molecular weight mucopolysaccharide that slows down bone resorption, reduces the loss of calcium ions, and participates in the formation of cartilage tissue.
The drug improves calcium-phosphorus metabolism in cartilaginous tissue, inhibits degenerative processes in cartilaginous and connective tissues. Accelerates the regenerative processes in the cartilage. Suppresses the activity of enzymes that cause damage to cartilage tissue. Increases the production of intra-articular fluid. Stimulates the synthesis of glycosaminoglycans. Promotes the regeneration of the cartilaginous surfaces of the joints and articular bag.
Chondroitin sulfate is structurally close to heparin, and therefore has the ability to prevent the formation of fibrin thrombi in the subchondral and synovial microvasculature.
Chondroitin-VERTEX reduces pain syndrome, increases the range of motion in the affected joint. It slows down the progression of joint diseases such as osteochondrosis and osteoarthritis.
Pharmacokinetics
In experimental studies carried out on mice, the radioactive isotope 3 H-chondroitin sulfate was used. Data were obtained that the drug is absorbed by only 14%. The auxiliary component dimethyl sulfoxide contained in the gel improves the penetration of Chondroitin through cell membranes.
After applying Chondroitin-VERTEX to the skin, the active substance quickly but selectively penetrates the joint, reaching a maximum concentration within 30 minutes. Subsequently, it is excreted in a two-phase way. The fast phase of elimination is completed 1 hour after the application of the drug.
Chondroitin sulfate is retained in the joint for about 5 hours.
Indications for use
Chondroitin-VERTEX is used in the treatment and prevention of osteochondrosis, osteoarthritis of the peripheral joints and the spine.
Contraindications
The drug is contraindicated in case of hypersensitivity to its components.
The gel should not be applied to the skin if the integrity of its integument is violated.
With caution, Chondroitin-VERTEX is prescribed to children under 18 years of age, pregnant and breastfeeding women.
Chondroitin-VERTEX, instructions for use: method and dosage
Chondroitin-VERTEX gel is used externally.
The drug should be applied to the skin over the lesion 2–3 times a day and gently rubbed in for 2–3 minutes until completely absorbed.
The duration of treatment is determined individually. It can be from 2 to 12 weeks. If necessary, the therapeutic course is repeated.
Side effects
There are rare cases of allergic reactions.
Overdose
There have been no reports of an overdose of chondroitin when used externally.
special instructions
Care should be taken when applying the gel, not allowing the drug to get on the mucous membranes and open wounds.
Influence on the ability to drive vehicles and complex mechanisms
The use of Chondroitin-VERTEX in the form of a gel does not adversely affect the speed of motor and mental reactions, as well as the ability to concentrate.
Application during pregnancy and lactation
There is no information on the safety of using chondroitin during pregnancy, so the drug can only be used as directed by a doctor, who must assess the balance of benefits and possible risks.
There is no information on the effect of the drug when used by nursing mothers. During lactation, Chondroitin-VERTEX is used with caution and only as directed by a doctor.
Pediatric use
Chondroitin-VERTEX gel is used with caution for the treatment of children and adolescents under 18 years of age.
Drug interactions
There are no known cases of incompatibility or drug interaction of Chondroitin-VERTEX with other drugs.
Analogs
Analogs of Chondroitin-VERTEX are Artravir-Inkampharm, Mukosat, Artrakam, Artogistan, Glucosamine, Chondroitin, Tazan, Chondroitin-AKOS, Chondromed-Lekpharm, Hondrofen, etc.
Terms and conditions of storage
Keep out of the reach of children at a temperature not exceeding 25 ° C.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Available without a prescription.
Reviews of Chondroitin-VERTEX
The drug is recommended for use by about 95% of users who left their reviews about Chondroitin-VERTEX on specialized medical sites.
As indicated by patients, this drug is effective and affordable, well tolerated, almost odorless, leaves no greasy residue and does not stick. The disadvantage of most people is the significant consumption of the gel.
Price for Chondroitin-VERTEX in pharmacies
The price of Chondroitin-VERTEX in the form of a gel for external use 5% is from 180 rubles. for 1 tube of 30 g.
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
