Chondrogluxid - Instructions For Use, Price, Reviews, Analogues

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Chondrogluxide

Chondrogluxid: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Pharmacokinetics
4. 4. Indications for use
5. 5. Contraindications
6. 6. Method of application and dosage
7. 7. Side effects
8. 8. Overdose
9. 9. Special instructions
10. 10. Application during pregnancy and lactation
11. 11. Use in childhood
12. 12. In case of impaired renal function
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Chondroglucide

ATX code: M02AX10

Active ingredient: glucosamine + chondroitin sulfate (glucosamine + chondroitin sulfate)

Manufacturer: SINTEZ, JSC (Russia)

Description and photo updated: 20.11.2018

Prices in pharmacies: from 183 rubles.

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Chondrogluxide is a drug that regulates metabolism in cartilage tissue.

Release form and composition

Dosage form of Chondrogluxide:

• film-coated tablets: oval, biconvex, from white to almost white, surface roughness is permissible (in a cardboard box 6, 12 or 18 blisters of 5 pcs., or 2, 4 or 6 blisters of 15 pcs., or 1 polymer can of 30, 60 or 90 pcs.);
• gel for external use: with a yellowish tinge or colorless, has a specific odor (in a cardboard box 1 aluminum / laminate tube of 30, 50 or 100 g).

Composition of 1 tablet:

• active substances: glucosamine sulfate - 500 mg (sodium chloride glucosamine sulfate); sodium chondroitin sulfate - 500 mg;
• auxiliary components (core): low molecular weight povidone - 86 mg; calcium stearate - 17 mg; colloidal silicon dioxide - 8.5 mg; talc - 51 mg; Kollidon CL - 170 mg; potato starch - 4.5 mg; ludipress (povidone - 3-4%; lactose monohydrate - 91-95%; crospovidone - 3-4%) - until a nucleus weighing 1700 mg is obtained;
• shell: titanium dioxide -16.5 mg; polyethylene glycol 4000 - 23.8 mg; propylene glycol - 2.5 mg; hydroxypropyl methylcellulose - 27.2 mg.

Composition of 100 mg gel:

• active substances: sodium chondroitin sulfate - 5 mg; glucosamine hydrochloride - 2.5 mg;
• auxiliary components: sodium disulfite - 0.05 mg; methyl parahydroxybenzoate - 0.2 mg; 96% ethanol - 25 mg; propylene glycol - 10 mg; lavender oil - 0.05 mg; carbopol - 3 mg; purified water - up to 100 mg.

Pharmacological properties

Pharmacodynamics

Chondrogluxide is one of the drugs that regulate the metabolism in cartilage tissue (chondroprotector). It stimulates the regeneration of cartilage tissue, has an analgesic and anti-inflammatory effect.

The active substances of Chondrogluxid take part in the synthesis of connective tissue, stimulate tissue regeneration and help prevent the processes of cartilage destruction.

Properties of active ingredients:

• sodium chondroitin sulfate: is an acidic mucopolysaccharide from the cartilaginous tissue of the trachea of cattle, a stimulator of the repair of connective (including cartilaginous) tissue. Stimulates the synthesis of proteoglycans and type II collagen, the formation of components of articular cartilage, and also protects hyaluron from enzymatic degradation (suppression of hyaluronidase activity) and the damaging effect of free radicals. It stimulates the mechanisms of cartilage repair, maintains the viscosity of the synovial fluid and inhibits the activity of enzymes that break down cartilage (elastase, hyaluronidase). In the treatment of osteoarthritis, relieves the symptoms of the disease and reduces the need for non-steroidal anti-inflammatory drugs;
• glucosamine: is a specific substrate and stimulator of the synthesis of hyaluronic acid and proteoglycans, participates in the biosynthesis of proteoglycans and hyaluronic acid, has chondroprotective properties, selectively affects articular cartilage, inhibits the formation of peroxide radicals and enzymes that damage cartilage tissue.

Pharmacokinetics

The bioavailability of glucosamine when taken orally is 25% (the effect of the first passage through the liver). The highest concentrations of the substance are found in the kidneys, liver and articular cartilage. Approximately 30% of the dose persists for a long time in muscle and bone tissues. Excretion of glucosamine occurs mainly unchanged by the kidneys; part of the substance is excreted by the intestines. The half-life is 68 hours.

The concentration of chondroitin sulfate in plasma when taken orally in a daily dose of 800 mg (once or twice a day, 400 mg) increases over 24 hours. Its absolute bioavailability is 12%. Approximately 10 and 20% of the dose is absorbed as high- and low-molecular derivatives, respectively. The apparent volume of distribution is approximately 0.44 ml / g. Chondroitin sulfate is metabolized by desulfurization, excreted by the kidneys. The half-life of the substance is 310 minutes.

Indications for use

According to the instructions, Chondrogluxid is prescribed for the treatment of stage I-III osteoarthritis (including the spine and joints).

Contraindications

Absolute:

• severe renal dysfunction (tablets);
• violation of the integrity of the skin in the intended place of application of the drug (gel);
• age up to 18 years;
• pregnancy and the period of breastfeeding;
• individual intolerance to the components of the drug.

Relative (Chondrogluxide in the form of tablets is prescribed under medical supervision):

• bleeding, bleeding tendency;
• bronchial asthma;
• diabetes.

Instructions for the use of Chondrogluxide: method and dosage

Pills

Chondrogluxid tablets are taken orally.

For 21 days, the drug is applied 2 times a day, 1 tablet, then until the end of therapy, the frequency of administration is reduced to 1 time per day. A stable therapeutic effect is achieved, as a rule, with a duration of use of at least 6 months.

Gel

Chondrogluxid gel is applied externally.

The gel is applied in a thin layer with a 4 cm strip (2000 mg) over the affected area on intact skin 2-3 times a day. The drug should be rubbed in for 2-3 minutes until absorbed. The duration of the course is 30 days. A repeated course is possible.

Side effects

Pills

While taking Chondrogluxide tablets, the development of dysfunctions of the digestive system (manifested in the form of epigastric pain, flatulence, diarrhea / constipation), headache, dizziness, skin allergic reactions, tachycardia, pain in the legs and peripheral edema, drowsiness / insomnia, reactions hypersensitivity.

Gel

When applying the gel, allergic reactions are possible.

Overdose

There is no evidence of an overdose of Chondrogluxide.

In the event of a possible systemic overdose (tablets), gastric lavage and symptomatic treatment are recommended.

special instructions

If during the period of taking Chondrogluxide inside the development of undesirable effects from the digestive system is observed, the daily dose is reduced by 2 times. In the absence of improvement, therapy is canceled.

In cases where, after the application of Chondrogluxide, 4 tablets per day for four weeks, there is no clinical effect, it is necessary to decide the question of clarifying the diagnosis.

Contact with the gel on open wounds, mucous membranes and eyes should be avoided.

Influence on the ability to drive vehicles and complex mechanisms

Care must be taken when taking Chondrogluxid orally while driving.

Application during pregnancy and lactation

Chondrogluxide is not prescribed during pregnancy / lactation.

Pediatric use

For patients under 18 years of age, the drug is not prescribed.

With impaired renal function

Severe renal impairment is a contraindication for oral administration of the drug.

Drug interactions

With the combined use of Chondrogluxide in the form of tablets with some drugs / substances, the following effects may develop:

• tetracyclines: increasing their absorption;
• semi-synthetic penicillins and glucosamine: reducing their action;
• anticoagulants, antiplatelet agents, fibrinolytics: enhancing their action.

Chondrogluxide can be used in combination with glucocorticosteroids and non-steroidal anti-inflammatory drugs.

There are no data on the possible interaction of Chondrogluxide in the form of a gel with other drugs.

Analogs

Chondrogluxide analogs are: ARTPA, Artravir-complex-INCAMFARM, KONDRONOVA, Tazan, Structum, Hondroflex, Teraflex.

Terms and conditions of storage

Store in a place protected from light and moisture at temperatures up to 25 ° C. Do not freeze the gel. Keep out of the reach of children.

Shelf life: tablets - 3 years; gel - 2 years.

Terms of dispensing from pharmacies

Dispensed: tablets - by prescription; gel - no prescription.

Reviews of Chondrogluxide

According to reviews, Chondrogluxide, when applied externally in the form of a gel, is an effective drug in the treatment of osteoarthritis. At the same time, it is noted that therapy should be carried out for a long time.

In some cases, they indicate an insufficient therapeutic effect, as well as the development of side reactions, mainly in the form of local rashes at the site of application of the drug.

Price for Chondrogluxide in pharmacies

The approximate price for Chondrogluxid gel (1 tube of 30, 50 or 100 g) is 58–84 rubles.

Chondrogluxide: prices in online pharmacies

Drug name Price Pharmacy

Chondrogluxid 5% gel for external use 30 g 1 pc. 183 r Buy

Maria Kulkes Medical journalist About the author

Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!