Tinidazole-Acri
Tinidazole-Acri: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. Drug interactions
- 12. Analogs
- 13. Terms and conditions of storage
- 14. Terms of dispensing from pharmacies
- 15. Reviews
- 16. Price in pharmacies
Latin name: Tinidazol-Akri
ATX code: P01AB02
Active ingredient: Tinidazole (Tinidazole)
Producer: JSC "Chemical and pharmaceutical plant" Akrikhin "(Russia)
Description and photo update: 2020-11-02
Prices in pharmacies: from 44 rubles.
Buy
Tinidazole-Acri is an antimicrobial and antiprotozoal drug.
Release form and composition
Dosage form - film-coated tablets: white or white with a creamy or grayish tint, biconvex, round; the color of the tablets at the break is white with a yellowish-greenish or yellowish tinge (in a cardboard box 1 cell contour package containing 4 tablets and instructions for use of Tinidazole-Acri).
Composition of 1 tablet:
- active substance: tinidazole - 500 mg;
- auxiliary components: stearic acid, talc, potato starch, sorbitol, pregelatinized starch;
- film shell: talc, titanium dioxide, glycerin (glycerol), polyethylene glycol 6000 (macrogol), hydroxypropyl methylcellulose (hypromellose).
Pharmacological properties
Pharmacodynamics
Tinidazole-Acri is an antiprotozoal agent with antimicrobial action. Shows activity against vaginal Trichomonas, dysentery amoeba and lamblia.
Anaerobic organisms against which the drug has a bactericidal effect include Veillonella spp., Peptostreptococcus spp., Peptococcus spp., Fusobacterium spp., Eubacterium spp., Clostridium spp., Bacteroides spp., Including B. melilaninogenicus and B. …
The mechanism of action of the drug is due to inhibition of synthesis and damage to the structure of deoxyribonucleic acid of pathogens.
Pharmacokinetics
Tinidazole is characterized by a high absorption rate. The maximum plasma concentration is observed 2 hours after oral administration of 2 g of the substance and is in the range from 40 to 51 μg / ml, after 24 hours - in the range from 11 to 19 μg / ml, after 72 hours - 1 μg / ml. Its bioavailability is about 100%.
The substance binds to plasma proteins at about 12%, its volume of distribution is 50 liters. Within 72 hours after administration, tinidazole is excreted in breast milk, penetrates the placental and blood-brain barrier.
The metabolic process is carried out in the liver. In this case, pharmacologically active hydroxylated derivatives are formed that can suppress the growth of anaerobic microorganisms and enhance the effect of the drug. The half-life of tinidazole varies from 12 to 14 hours. It is excreted mainly in the bile (by 50%), to a lesser extent unchanged in the kidneys (by 25%) and in the form of metabolites (by 12%) by reabsorption in the kidneys tubules.
Indications for use
- amebiasis, including hepatic and intestinal forms;
- trichomoniasis - tubo-ovarian and ovarian abscess, endometritis, colpitis;
- giardiasis;
- infections caused by anaerobic bacteria - acute ulcerative gingivitis, skin and soft tissue infections, lung abscess, pleural empyema, pneumonia;
- mixed aerobic-anaerobic infections (as part of combination therapy with antibacterial agents);
- Helicobacter pylori (eradication as part of combination therapy with antibiotics and bismuth preparations);
- postoperative infectious complications caused by anaerobes (for the purpose of prevention).
Contraindications
Absolute:
- disorders of hematopoiesis;
- organic diseases of the central nervous system;
- I trimester pregnancy;
- lactation period;
- age up to 12 years;
- established hypersensitivity to the components of the drug and other derivatives of 5-nitroimidazole.
With caution, under close medical supervision, Tinidazole-Acri can be used in the II and III trimester of pregnancy.
Tinidazole-Acri, instructions for use: method and dosage
Tinidazole-Acri tablets are intended for oral administration. A single dose should be taken with or after meals.
Recommended dosage regimen depending on indications:
- giardiasis, trichomoniasis: adults - once, 2 g per day; for children over 12 years of age, the dose is set at the rate of 50–75 mg per 1 kg of body weight per day. If necessary, repeated administration of Tinidazole-Acri in the same dose is allowed;
- intestinal amebiasis: adults - 2 g per day for 2-3 days. The daily dose for children is set on the basis of 50-60 mg per 1 kg of body weight, the duration of treatment is 3 days;
- hepatic amebiasis: the initial dose for adults is 1.5 to 2 g per day. The duration of the course is 3 days with a possible extension of up to 6 days, if necessary. Depending on the severity of the infection, the course dose is in the range from 4.5 to 12 g. For children, the drug is prescribed in a dose determined at the rate of 50–60 mg per 1 kg of body weight per day, the duration of therapy is 5 days;
- infections caused by anaerobes: the dose on the first day of use for adults - 2 g, then - 1 g daily for 5-6 days;
- prevention of postoperative complications: 12 hours before the intervention, adults take a single dose of 2 g of the drug.
Side effects
Possible side effects of Tinidazole-Acri [> 10% - very common; (> 1% and 0.1% and 0.01% and <0.1%) - rarely; <0.01% - very rare; frequency cannot be established from the available data - with an unspecified frequency]:
- gastrointestinal tract: nausea, diarrhea, vomiting, unpleasant taste and dry mouth, anorexia;
- central nervous system: dizziness, headache, peripheral neuropathy, ataxia; rarely - convulsions;
- allergic reactions: skin rash / itching, angioedema, urticaria;
- others: rarely - weakness, transient leukopenia.
Overdose
In case of an overdose of Tinidazole-Acri, symptomatic therapy is recommended.
There is no specific antidote. Tinidazole is excreted during dialysis.
special instructions
With trichomoniasis, treatment should be carried out simultaneously in both partners.
In view of the possible appearance of disulfiram-like reactions, during the period of use of the drug, it is necessary to refrain from using ethanol.
It should be taken into account that tinidazole contributes to the dark coloration of urine.
In patients taking Tinidazole-Acri for more than 6 days, the peripheral blood picture should be monitored.
Influence on the ability to drive vehicles and complex mechanisms
During the period of therapy with Tinidazole-Acri tablets, it is prohibited to drive vehicles, as well as perform other work associated with increased attention.
Application during pregnancy and lactation
The drug is not prescribed in the first trimester of pregnancy and during breastfeeding.
It is allowed to use Tinidazole-Acri in the II and III trimester of pregnancy only in cases where the predicted therapeutic benefit to the mother is higher than the possible risks to the developing fetus.
If taking the drug is necessary against the background of lactation, it is necessary to decide on the termination of breastfeeding. It is important to take into account that tinidazole is determined in breast milk for 72 hours after taking it.
Pediatric use
The use of Tinidazole-Acri in children under the age of 12 years is contraindicated, since the safety and efficacy profile of its use in patients of this age group has not been established.
Drug interactions
Recommended combinations to take into account:
- indirect anticoagulants: their effect is enhanced (to reduce the likelihood of bleeding, the dose is reduced by 2 times);
- ethanol: its effect is enhanced (disulfiram-like effect);
- phenobarbital: increases the metabolic rate of the drug;
- antibacterial drugs (cephalosporins, rifampicin, erythromycin, aminoglycosides) and sulfonamides: compatible with tinidazole;
- ethionamide: combined use with tinidazole is not recommended.
Analogs
Analogs of Tinidazole-Acri are Klion, Metronidazole, Pilobact, Tinidazole, Tiniba, Tsiprolet A, Tsifran ST, Fazizhin, etc.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews of Tinidazole-Acri
Patients leave mostly positive reviews about Tinidazole-Acri. The advantages most often include the budgetary cost of the drug, high efficiency and rapid development of therapeutic action.
The most significant disadvantages are considered negative side reactions, among which, as a rule, bitterness in the mouth, headache, dizziness, stomach pain and diarrhea are noted.
The price of Tinidazole-Acri in pharmacies
Approximate price for Tinidazole-Acri, film-coated tablets, 500 mg, 4 pcs. in the package is 115 rubles.
Tinidazole-Acri: prices in online pharmacies
|
Drug name Price Pharmacy |
|
Tinidazole-Acri 500 mg film-coated tablets 4 pcs. RUB 44 Buy |
Anna Kozlova Medical journalist About the author
Education: Rostov State Medical University, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
