Phenylin
Instructions for use:
- 1. Pharmacological properties
- 2. Release form
- 3. Indications for use
- 4. Contraindications
- 5. Instructions for use
- 6. Side effects
Prices in online pharmacies:
from 73 rub.
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Phenylin is a blood clotting agent.
Pharmacological properties
Phenylin is included in the group of indirect anticoagulants.
According to the mechanism of action, it belongs to the antagonists of vitamin K. Competing with vitamin K, Phenylin blocks the enzyme K-vitamin reductase. Because of this, the synthesis in the liver of blood coagulation factors - VII, IX, X and prothrombin is disrupted. The deficiency of coagulation factors disrupts the processes of thrombus formation, reduces the content of lipids in the blood, makes the vessels more permeable.
To start working in the body, Phenilin must accumulate to a certain concentration, therefore its effect does not appear immediately - it begins after 8-10 hours, and the maximum effect is achieved after 24-30 hours.
The control of the anticoagulant effect of Fenilin is based on the determination of the prothrombin time in the coagulogram - PV, normally it is 11-14 seconds. To prevent venous thrombosis, an increase in PT by 2 times, arterial by 3-4 times compared with the norm is sufficient.
Phenylin is rapidly and well absorbed from the digestive tract. Its transformation takes place in the liver. It is excreted from the body in the form of metabolites by the kidneys.
Release form
The drug is available in 30 mg tablets.
Indications for the use of Fenilin
According to the instructions, the drug is used in those conditions when a long-term decrease in blood clotting is necessary. It is used to prevent and treat thrombosis, thrombophlebitis and thromboembolic complications (pulmonary embolism, etc.), as well as thrombosis in the postoperative period. Constant use of Fenilin is necessary if a person has mechanical prosthetic heart valves. The drug is used in complex anticoagulant therapy together with heparin.
Contraindications
It is necessary to take the medicine under the control of blood clotting. If the level of prothrombin is below 70% of the norm, there is a great danger of bleeding. Phenilin is not prescribed for blood diseases associated with clotting disorders (hemophilia, hemorrhagic diathesis), with severe renal failure, in the 1st trimester of pregnancy and with individual intolerance. It is recommended to use this remedy with caution in old age, with oncological diseases, disorders in the functioning of the kidneys and liver, with ulcers and erosions in the digestive tract, with anemia and gynecological diseases, in the early postpartum period, with lactation. 2 days before the onset of menstruation, the drug must be canceled.
Instructions for the use of Fenilin
According to the instructions, the dose of the drug is selected according to the indications of the duration of the prothrombin time, maintaining the prothrombin index at the level of 40-60%. On the first day, the loading dose is 120-180 mg orally in 3-4 doses, on the second - 90-150 mg / day, then - under the control of PTV at 30-60 mg / day. The maximum daily dose of Phenilin is 200 mg.
While taking the drug, you should regularly monitor the coagulogram, thromboelastogram, the level of platelets in the blood, as well as urine for possible hematuria.
Discontinue drug treatment gradually. Sometimes patients' palms turn yellow and urine pink. In case of an overdose of Phenilin, vitamin K will be its antagonist; in acute cases, it is administered parenterally.
Side effects of Fenilin
According to reviews, phenylin can cause nausea, diarrhea, headaches, fever, allergic reactions, toxic hepatitis, and hematopoietic disorders.
Long-term use sometimes provokes the development of hemorrhagic syndrome in the form of nasal, uterine, renal, gastrointestinal bleeding, hemorrhage into internal organs or muscles.
Phenilin: prices in online pharmacies
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Drug name Price Pharmacy |
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Phenilin 30 mg tablets 20 pcs. 73 rbl. Buy |
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
