Methylergobrevin
Methylergobrevin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. In case of impaired renal function
- 11. For violations of liver function
- 12. Drug interactions
- 13. Analogs
- 14. Terms and conditions of storage
- 15. Terms of dispensing from pharmacies
- 16. Reviews
- 17. Price in pharmacies
Latin name: Methylergobrevin
ATX code: G02AB01
Active ingredient: methylergometrine (Methylergometrine)
Manufacturer: Hemofarm A. D. (Hemofarm AD) (Serbia)
Description and photo update: 2019-08-10
Methylergobrevin is a drug that increases the tone and contractile activity of the myometrium.
Release form and composition
The drug is produced in the form of a solution for intravenous (i / v) and intramuscular (i / m) administration: clear, colorless liquid (1 ml each in an ampoule of colorless glass of I hydrolytic class, 5 ampoules in a blister strip, 10 contour packs in a cardboard box and Instructions for the use of Methylergobrevin).
1 ml of solution contains:
- active substance: methylergometrine maleate - 0.2 mg;
- additional components: sodium chloride, maleic acid, thiocarbamide, glycine, water for injection.
Pharmacological properties
Pharmacodynamics
Methylergobrevin is a semi-synthetic derivative of ergometrine, a natural ergot alkaloid. The drug provides an increase in the tone and contractile activity of the myometrium, has a weak effect on peripheral vessels, and practically does not lead to an increase in blood pressure (BP).
Pharmacokinetics
The therapeutic effect of methylergometrine after intravenous administration appears after 30-60 seconds, after intramuscular administration - after 2-5 minutes. The duration of its therapeutic action is up to 2 hours after intravenous administration, and 3 hours or more after intravenous administration.
Methylergometrine binds to plasma proteins by 35%. Its volume of distribution (V d) is 39.1-73.1 l, clearance - 9.9-18.9 l / h. The drug is characterized by an intensive distribution over the tissues of the body - after intravenous administration, the half-distribution period (T 1/2 d) is 1–3 minutes. It is detected in breast milk.
The agent is metabolized in the liver, excreted mainly in the feces, partly in the urine.
Indications for use
- II stage of labor after the appearance of the anterior part of the shoulder of the fetus (in order to shorten the duration of the period);
- metrorrhagia (uterine bleeding), including atonic;
- hypotonic bleeding in the early postpartum period (prevention and treatment);
- postoperative bleeding (removal of fibroids, cesarean section) and post-abortion.
Contraindications
Absolute:
- pregnancy;
- I period of childbirth;
- II stage of labor before the appearance of the fetal head;
- occlusive lesions of peripheral vessels;
- arterial hypertension in severe form;
- sepsis;
- hypersensitivity to ergot preparations.
Relative (Methylergobrevin must be used with caution):
- cardiovascular diseases;
- renal and / or hepatic impairment;
- the need for manual separation of the placenta.
Methylergobrevin, instructions for use: method and dosage
Methylergobrevin solution is administered (i / v) and intramuscularly (i / m).
Recommended dosage regimen depending on indications:
- atonic uterine bleeding: used intravenously, 0.1 mg (0.5 ml) or intramuscularly - 0.2 mg (1 ml), if necessary, with an interval of 2 hours, administration can be repeated;
- metrorrhagia: injected intramuscularly at 0.1–0.2 mg or intravenously at 0.1 mg;
- childbirth: with careful obstetric control to shorten the II stage of labor, 0.1–0.2 mg is injected intravenously only after the appearance of the head or the anterior part of the fetal shoulder; in the case of labor under general anesthesia, it is recommended to use 0.2 mg; if the introduction of the solution into the vein is impossible, then it is used in / m at 0.2-0.4 mg;
- abortion: used after the expansion of the cervical canal in / in, 0.1-0.2 mg, for spontaneous abortions - 0.05-0.1 mg;
- Caesarean section: used after fetal extraction 0.05–0.1 mg intravenously or 0.2 mg intramuscularly.
Side effects
- allergic reactions: skin rash, extremely rarely - anaphylactic shock;
- nervous system: headache, dizziness, stroke;
- organ of hearing: tinnitus;
- cardiovascular system: chest pain, dyspnea, transient increase in blood pressure, peripheral vasospasm, bradycardia, myocardial infarction;
- digestive system: nausea, vomiting, abdominal pain;
- other reactions: increased sweating, pulmonary edema; extremely rare - a decrease in milk secretion.
Overdose
Symptoms of an overdose of Methylergobrevin may include numbness and tingling in the extremities, vomiting, nausea, abdominal pain, increased blood pressure (in severe cases, accompanied by hypothermia, respiratory depression, convulsions and coma).
In this condition, symptomatic treatment is prescribed under close control of the functions of the cardiovascular and respiratory systems.
special instructions
Treatment with the drug should be carried out only in a specialized hospital, subject to strict medical control of blood pressure, heart rate (HR) and the activity of uterine contractile activity.
In the case of using Methylergobrevin immediately after the birth of the child, when the placenta still remains in the uterine cavity, the drug may interfere with the separation of the placenta.
Application during pregnancy and lactation
Treatment with Methylergobrevine during pregnancy, in the first stage of labor and in the second stage of labor before the birth of the fetal head is contraindicated.
Breastfeeding women are not recommended to use the drug.
With impaired renal function
In the presence of renal failure, Methylergobrevin should be used with extreme caution.
For violations of liver function
In the presence of liver failure, Methylergobrevin should be used with extreme caution.
Drug interactions
- oxytocin: the effectiveness of this combination is noted in the prevention and treatment of atonic uterine bleeding;
- sympathomimetics, ergotamine: it is possible to enhance the vasopressor effects of these drugs;
- fluorothane: the sensitivity of the uterus decreases and the activity of methylergometrine decreases;
- dopamine: the combination is contraindicated, since against its background the risk of developing gangrene of the extremities is aggravated.
Analogs
Ergometrine, Carbetocin, Mifepristone, Mifeprex, Mifegin, Oxytocin, etc. are analogs of Methylergobrevine.
Terms and conditions of storage
Store in a place protected from light, out of reach of children, at a temperature not exceeding 25 ° C.
The shelf life is 3 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Methylergobrevin
On medical sites, reviews of Methylergobrevine are extremely rare and mainly indicate the effectiveness of this drug when used for the prevention and treatment of bleeding in the early postpartum period and after medical abortion.
There are no complaints about the development of undesirable side reactions.
Price for Methylergobrevin in pharmacies
The price of Methylergobrevin, a solution for intravenous and intramuscular administration (200 μg / ml), can be 290-310 rubles. per package containing 50 ampoules of 1 ml.
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
