Pagluferal-3
Pagluferal-3: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Pagluferalum-3
ATX code: N05CB02
Active ingredient: bromized (bromisoval) + calcium gluconate (calcium gluconate) + caffeine (caffeine) + papaverine (papaverine) + phenobarbital (phenobarbital)
Producer: Moscow pharmaceutical factory (Russia)
Description and photo update: 2018-21-11
Prices in pharmacies: from 97 rubles.
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Pagluferal 3 is a combined drug with antiepileptic, hypnotic effects.
Release form and composition
Dosage form Pagluferal 3 - tablets: white, with a chamfer and a dividing line on one side (in a cardboard box, 2 blisters of 10 tablets each or 1 dark glass jar - 40 tablets).
Active ingredients in 1 tablet:
- bromized - 150 mg;
- phenobarbital - 50 mg;
- caffeine sodium benzoate - 10 mg;
- calcium gluconate - 250 mg;
- papaverine hydrochloride - 20 mg.
Auxiliary components of Pagluferal 3: potato starch - 95 mg; calcium stearate - 5 mg.
Pharmacological properties
Pharmacodynamics
Pagluferal 3 is a combined antiepileptic drug.
Its action is due to the properties of the constituent components:
- phenobarbital: has sedative, anticonvulsant, antispasmodic and hypnotic effects. It interacts with the barbiturate site of the benzodiazepine-GABA-receptor complex, thereby increasing the sensitivity of GABA-receptors to GABA (gamma-aminobutyric acid). This leads to the opening of neuronal channels for chlorine ions and, as a consequence, an increase in their entry into cells. Promotes the development of the following effects: decrease in the excitability of neurons of the epileptogenic focus and the spread of nerve impulses; suppression of sensory areas of the cerebral cortex; manifestation of antagonism against a number of excitatory mediators (glutamate and others); decreased tone of smooth muscles of the gastrointestinal tract; decrease in motor activity, inhibition of cerebral functions (including the respiratory center);
- papaverine hydrochloride: has a hypotensive and antispasmodic effect; relaxes smooth muscles and lowers the tone of internal organs and blood vessels;
- caffeine: stimulates the vasomotor and respiratory centers, increases the reflex excitability of the spinal cord, stimulates metabolic processes in tissues and organs, including in the central nervous system and muscle tissues;
- bromized: has sedative and moderate hypnotic effects;
- calcium gluconate: necessary to replenish the deficiency of calcium ions involved in the transmission of nerve impulses.
Pharmacokinetics
- phenobarbital: complete and slow absorption. The time to reach Cmax (maximum concentration of the substance) in blood plasma is 1–2 hours, the connection with plasma proteins is approximately 50%. Metabolism occurs in the liver, induces microsomal liver enzymes CYP3A4, CYP3A5, CYP3A7 (the rate of enzymatic reactions increases 10-12 times). Accumulates in the body. T 1/2 (half-life) is 48–96 hours. It is excreted by the kidneys in the form of glucuronide, in unchanged form - approximately 25%. Penetrates through the placental barrier and into breast milk;
- caffeine: characterized by good absorption that occurs throughout the intestine. The time to reach Cmax in blood plasma is from 50 to 75 minutes. It is distributed quickly in all tissues and organs, penetrates the blood-brain barrier and the placenta. The connection with blood proteins (albumin) is in the range of 25–36%. More than 90% of the substance is metabolized in the liver, in children of the first years of life - up to 10-15%. Approximately 80%, 4%, and 10% of the adult dose of caffeine is metabolized to paraxanthine, theophylline, and theobromine, respectively. Then these compounds are demethylated to monomethylxanthines, and later to methylated uric acids. In adults, T 1/2 is in the range of 3.9-5.3 hours (in some cases up to 10 hours). Caffeine and its metabolites are excreted by the kidneys;
- papaverine: on average, bioavailability is 54%. The connection with plasma proteins is approximately 90%. The substance is well distributed, penetrates the histohematogenous barriers. Metabolism occurs in the liver. T 1/2 is in the range of 30–120 minutes (can extend up to 1440 minutes). It is excreted in the form of metabolites by the kidneys;
- Calcium gluconate: about 1 / 5 - 1 / 3 dose absorbed in the small intestine. Approximately 20% is excreted by the kidneys, the rest is removed with the intestinal contents (most actively - by the wall of the terminal gastrointestinal tract).
Indications for use
According to the instructions, Pagluferal 3 is prescribed for the treatment of epilepsy.
Contraindications
- porphyria;
- severe hepatic / renal failure;
- severe anemia;
- depression;
- hypofunction of the adrenal glands;
- drug dependence (including a burdened history);
- myasthenia gravis;
- hyperthyroidism;
- active alcoholism;
- hyperkinesis;
- diabetes;
- broncho-obstructive diseases;
- age up to 7 years;
- pregnancy and the period of breastfeeding;
- individual intolerance to the components of the drug.
In debilitated patients, Pagluferal 3 should be used under medical supervision, which is associated with a high risk of developing paradoxical agitation, confusion and depression, even with therapy at usual doses.
Instructions for the use of Pagluferal-3: method and dosage
Pagluferal 3 is intended for oral administration.
The frequency of admission is 2 times a day, preferably after meals.
Recommended single dose:
- children over 14 years old and adults: 2 tablets;
- children 10-14 years old: 1.5 tablets;
- children 7-9 years old: 1 tablet.
Side effects
- cardiovascular system: tachycardia, decrease / increase in blood pressure, arrhythmia (including extrasystole), atrioventricular block;
- nervous system: sleep disorders, hallucinations, nystagmus, dizziness, general weakness, dysarthria, ataxia, paradoxical reaction;
- hematopoietic system: megaloblastic anemia, agranulocytosis, thrombocytopenia;
- digestive system: nausea, constipation / diarrhea, vomiting, increased activity of hepatic transaminases;
- others: allergic reactions, with a long course of administration - drug dependence.
Overdose
The main symptoms: increased severity of side effects.
Therapy: symptomatic, gastric lavage, intake of activated charcoal.
special instructions
With a slight hypercalciuria, a decrease in glomerular filtration or nephrolithiasis in the anamnesis during drug therapy, it is necessary to monitor the calcium content in the urine (due to the presence of calcium gluconate in the composition of Pagluferal 3).
You should not drink alcohol during therapy.
Influence on the ability to drive vehicles and complex mechanisms
While taking Pagluferal, 3 patients are advised to refrain from driving vehicles.
Application during pregnancy and lactation
Pagluferal 3 is not prescribed during pregnancy / lactation.
Pediatric use
It is contraindicated to carry out therapy to patients under 7 years of age.
With impaired renal function
Pagluferal 3 is contraindicated in severe renal failure.
For violations of liver function
Pagluferal 3 is contraindicated in severe hepatic failure.
Drug interactions
- phenytoin and valproate: serum phenobarbital in the blood increases;
- reserpine: the effectiveness of phenobarbital decreases;
- amitriptyline, nialamide, diazepam, chlordiazepoxide: the effect of phenobarbital increases;
- oral contraceptives and salicylates: their effectiveness decreases;
- indirect anticoagulants, glucocorticosteroids, griseofulvin, doxycycline, estrogens and other drugs metabolized in the liver by oxidation: their content in the blood decreases (due to the acceleration of metabolism);
- ethanol, antipsychotics, narcotic analgesics, muscle relaxants, sedatives and hypnotics: their effect is enhanced;
- acetazolamide: reabsorption of phenobarbital in the kidneys decreases, as a result of which its effect is weakened (due to alkalization of urine);
- antibiotics, sulfonamides: antibacterial activity decreases;
- griseofulvin: the antifungal effect is reduced.
Analogs
Analogs of Pagluferal 3 are: Pagluferal-1, Pagluferal-2.
Terms and conditions of storage
Store in a place protected from light and moisture at temperatures up to 25 ° C. Keep out of the reach of children.
Shelf life is 2 years.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Pagluferal-3
According to reviews, Pagluferal 3 is an effective antiepileptic drug. They also note a positive trend when it is prescribed for the treatment of sleep disorders (fears, frequent waking up).
Price for Pagluferal-3 in pharmacies
The approximate price for Pagluferal 3 (20 pcs. Per pack) is 106–124 rubles.
Pagluferal-3: prices in online pharmacies
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Drug name Price Pharmacy |
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Pagluferal-3 tablets 20 pcs. RUB 97 Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
