Nystatin - Instructions For Use, Price, Tablets, Ointment, Suppositories

2024 Author: Rachel Wainwright | [email protected]. Last modified: 2023-12-15 07:39

Nystatin

Nystatin: instructions for use and reviews

1. 1. Release form and composition
2. 2. Pharmacological properties
3. 3. Indications for use
4. 4. Contraindications
5. 5. Method of application and dosage
6. 6. Side effects
7. 7. Overdose
8. 8. Special instructions
9. 9. Application during pregnancy and lactation
10. 10. Use in childhood
11. 11. In case of impaired renal function
12. 12. For violations of liver function
13. 13. Drug interactions
14. 14. Analogs
15. 15. Terms and conditions of storage
16. 16. Terms of dispensing from pharmacies
17. 17. Reviews
18. 18. Price in pharmacies

Latin name: Nystatin

ATX code: A07AA02

Active ingredient: nystatin (nystatin)

Producer: Biochemist (Russia), Biosynthesis, JSC (Russia), Irbitskiy Khimfarmzavod (Russia), NIZHFARM (Russia), Borisov Plant of Medical Products (Republic of Belarus)

Description and photo update: 2019-14-08

Prices in pharmacies: from 36 rubles.

Buy

Nystatin is an antifungal antibiotic drug.

Release form and composition

Nystatin is available in the following dosage forms:

• Film-coated or film-coated tablets: light yellow with a greenish tinge, with a slight vanillin odor, on a cross-section - two layers (20 pcs. In dark glass jars, plastic containers or polyethylene bottles, 1 can, container or bottle per cardboard box; 10, 20 pcs. in blisters, 1-3, 5 packages in a cardboard box);
• Suppositories for rectal use: yellow, torpedo-shaped, with a maximum diameter of 1.2 cm (5 pieces in blisters, 2 packages in a cardboard box);
• Vaginal suppositories: yellow, torpedo-shaped (5 pcs. In blisters, 2 packages in a cardboard box);
• Ointment for external use: brownish-yellow or yellow (10, 15, 25 or 30 g in aluminum or polymer tubes, 1 tube in a cardboard box).

The composition of 1 tablet includes:

• Active ingredient: nystatin - 250,000 or 500,000 units (units of action);
• Auxiliary components: milk sugar, liquid paraffin, basic magnesium carbonate, hydroxypropyl methylcellulose (OPMC), calcium stearic acid, potato starch, MC-16 (methylcellulose), pigment titanium dioxide, trolein O, tween 80, vanillin.

The composition of 1 rectal suppository includes:

• Active ingredient: nystatin - 250,000 or 500,000 units (units of action);
• Auxiliary components: paraoxybenzoic acid propyl ester, food citric acid, liquid paraffin, Witepsol W-35, Witepsol H-15.

The composition of 1 vaginal suppository includes:

• Active ingredient: nystatin - 250,000 or 500,000 units (units of action);
• Auxiliary components: paraoxybenzoic acid propyl ester, food citric acid, Witepsol W-35, Witepsol N-15.

The composition of 1 g of external ointment includes:

• Active ingredient: nystatin - 100,000 units;
• Auxiliary components: anhydrous lanolin, medical petroleum jelly.

Pharmacological properties

Pharmacodynamics

Nystatin is a polyene antifungal antibiotic with antifungal (fungicidal and fungistatic) activity. The structure of the preparation contains a large number of double bonds, which determines its high tropism for sterol formations of the cytoplasmic membrane of fungi. In this case, the molecule of the active substance is incorporated into the cell membrane with the formation of a large number of channels that provide uncontrolled transport of water, non-electrolytes and electrolytes. Under the action of this mechanism, the cell is lysed due to the loss of resistance to the influence of external osmotic forces. Drug resistance develops very slowly.

Nystatin is active against Aspergillus and Candida yeast. Has fungistatic and fungicidal (in large doses) action. Tolerance of sensitive fungi to nystatin develops very slowly.

Pharmacokinetics

Nystatin - 19-mycosaminylnistatinolide, is an antibiotic of the polyene group and is produced by the actinomycete Streptomyces noursei.

It is poorly absorbed from the gastrointestinal tract. The bulk of the drug taken orally is excreted in the feces. Does not show cumulative properties.

It is not absorbed from the skin surface.

When applied topically through the mucous membranes, it is practically not absorbed.

Indications for use

Tablets and ointment

• Internal candidiasis;
• Candidiasis of the mucous membranes and skin;
• Candidiasis with prolonged treatment with antimicrobial drugs, especially in debilitated and debilitated patients (prevention).

Vaginal suppositories

• Vaginal candidiasis;
• Fungal complications during local antimicrobial therapy (prevention).

Rectal suppositories

• Lower intestinal candidiasis;
• Fungal lesions in the pre- and postoperative periods (prevention).

Contraindications

• Functional disorders of the liver;
• Peptic ulcer of the stomach and duodenum;
• Pancreatitis;
• Pregnancy;
• Hypersensitivity to drug components.

Instructions for the use of Nystatin: method and dosage

Pills

Nystatin tablets are taken orally, regardless of food intake.

When treating candidiasis of internal organs, the following dosage regimen is recommended:

• Adults - 4-8 times a day, 500,000 IU (for generalized candidiasis - up to 6,000,000 IU per day);
• Children 1-3 years old - 3-4 times a day, 250,000 units; children from 3 years old - 4 times a day, 250,000-500,000 units.

The duration of the course is 10-14 days. If necessary, after a week, the course of treatment can be repeated.

External ointment

In the treatment of candidiasis of the mucous membranes and skin, the ointment is applied to the affected areas with a thin layer 2 times a day. Treatment should be carried out daily for 7-10 days.

It is possible to carry out combination therapy with Nystatin in the form of tablets.

Vaginal suppositories

Nystatin should be injected into the vagina after hygiene procedures.

Single dose - 1 suppository, frequency of application - 2 times a day (in the morning and evening). The duration of the course is 10-14 days.

Rectal suppositories

Suppositories Nystatin is injected deep into the rectum.

Single dose - 1 suppository, frequency of application - 2 times a day (in the morning and evening). The duration of the course is 10-14 days.

If necessary, it is possible to carry out repeated treatment courses.

Side effects

• Digestive system: vomiting, nausea, diarrhea (for tablets and rectal suppositories);
• Allergic reactions: chills, pruritus, fever;
• Others: there is a possibility of the spread of resistant forms of fungi, which may lead to the cancellation of therapy.

Overdose

Overdose cases of Nystatin have not been recorded.

special instructions

In cases of side effects, it is necessary to reduce the dose or discontinue therapy.

You should not interrupt treatment with vaginal suppositories during menstruation. In case of fungal diseases of the vagina, it is recommended to carry out simultaneous treatment of the sexual partner. During the period of therapy, it is necessary to avoid sexual intercourse.

Application during pregnancy and lactation

It is forbidden to use Nystatin in the form of tablets and vaginal suppositories during pregnancy.

The drug in the form of rectal suppositories is allowed to be used for the treatment of pregnant women, provided that the perceived risk to the fetus is lower than the potential benefit to the mother.

Nystatin in the form of an ointment can be used during pregnancy and breastfeeding.

There are no data on the release of the drug in the form of tablets with breast milk, therefore, if it is necessary to use it during lactation, it is recommended to stop breastfeeding.

It is allowed to use Nystatin in the form of vaginal suppositories and rectal suppositories during lactation (the drug is practically not absorbed through the mucous membranes).

Pediatric use

Nystatin ointment is allowed to be used to treat children.

It is forbidden to use the drug in the form of tablets for the treatment of patients under the age of 3 years.

According to the instructions, Nystatin in the form of vaginal and rectal suppositories cannot be used to treat patients under the age of 18 years.

With impaired renal function

Nystatin in tablet form should be used with caution in kidney disease.

For violations of liver function

Nystatin in the form of tablets is contraindicated for use in case of liver dysfunction.

Drug interactions

When Nystatin is used together with clotrimazole, the activity of the latter decreases.

Analogs

Analogs of Nystatin are: Levoy, Natamycin, Ketoconazole, Miconazole, Clotrimazole, Fluconazole, Intraconazole.

Terms and conditions of storage

Store in a dark, dry place out of reach of children.

Shelf life:

• Tablets - 2 years at a temperature of 18-20 ° C;
• Rectal and vaginal suppositories - 2 years at temperatures up to 5 ° C;
• Ointment for external use - 3 years at temperatures up to 5 ° C.

Terms of dispensing from pharmacies

The tablets are prescription, ointment and suppositories are available without a prescription.

Reviews about Nystatin

Reviews of Nystatin in the form of vaginal suppositories often contain information about the development of side effects (increased urination, burning sensation in the vagina, irritation). Also, women note that in case of termination of treatment, the symptoms that disappeared during the course of therapy returned after a while (the drug did not eliminate the pathogen). Many patients consider Nystatin insufficiently effective and prefer more modern antimycotic drugs.

Nystatin tablets are most often prescribed for the prevention of dysbiosis when taking antibiotics. Reviews of the drug contain information about side effects such as nausea and upset stools.

According to reviews, Nystatin ointment is effective in the treatment of mild forms of superficial candidiasis of the skin. For the treatment of severe fungal infections, it is recommended to supplement the ointment with systemic antimycotics.

Price for Nystatin in pharmacies

The approximate price for Nystatin is: 20 tablets of 500,000 U - 45 rubles, 100 tablets of 500,000 U - 160 rubles, 10 vaginal suppositories of 500,000 U - 110 rubles, ointment 15 g 100,000 U - 55 rubles., ointment 30 g 100,000 U - 85 rubles.

Nystatin: prices in online pharmacies

Drug name Price Pharmacy

Nystatin 100,000 U / g ointment for external use 15 g 1 pc. RUB 36 Buy

Nystatin 500000 IU film-coated tablets 20 pcs. 41 rbl. Buy

Nystatin 100,000 U / g Ointment for external use 30 g 1 pc. RUB 70 Buy

Nystatin 250,000 IU vaginal suppositories 10 pcs. 84 rbl. Buy

Nystatin 500000 IU rectal suppositories 10 pcs. RUB 88 Buy

Nystatin 250,000 IU rectal suppositories 10 pcs. 89 RUB Buy

Nystatin 500000 IU vaginal suppositories 10 pcs. RUB 95 Buy

Nystatin supp. vaginal 500 thousand units 10 pcs. RUB 138 Buy

Nystatin 500000 IU vaginal suppositories 10 pcs. 178 r Buy

Nystatin 500000 IU film-coated tablets 100 pcs. RUB 186 Buy

See all offers from pharmacies

Anna Kozlova Medical journalist About the author

Education: Rostov State Medical University, specialty "General Medicine".

Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!