Griseofulvin
Griseofulvin: instructions for use and reviews
- 1. Release form and composition
- 2. Pharmacological properties
- 3. Indications for use
- 4. Contraindications
- 5. Method of application and dosage
- 6. Side effects
- 7. Overdose
- 8. Special instructions
- 9. Application during pregnancy and lactation
- 10. Use in childhood
- 11. In case of impaired renal function
- 12. For violations of liver function
- 13. Drug interactions
- 14. Analogs
- 15. Terms and conditions of storage
- 16. Terms of dispensing from pharmacies
- 17. Reviews
- 18. Price in pharmacies
Latin name: Griseofulvin
ATX code: D01BA01
Active ingredient: griseofulvin (griseofulvin)
Manufacturer: Biosynthesis (Russia)
Description and photo update: 2019-20-08
Prices in pharmacies: from 192 rubles.
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Griseofulvin is an antifungal antibiotic with fungistatic action.
Release form and composition
Dosage form - tablets: white with a cream shade, odorless, bitter in taste (10 pcs. In a blister strip, 2 packs in a cardboard box).
The active ingredient is griseofulvin, in 1 tablet - 125 mg.
Pharmacological properties
Pharmacodynamics
Griseofulvin is an antifungal antibiotic. The mechanism of its action is explained by the ability to cause disruption of the structure of the mitotic spindle and cell wall synthesis in chitin-containing fungi, as well as suppress the division of fungal cells in the metaphase and protein synthesis, disrupting the connection with messenger RNA. The substance tends to accumulate in the cells of the skin, nails and hair.
The drug is active against fungi of the genus Microsporum, Trichophyton, Epidermophyton.
Pharmacokinetics
The absorption of griseofulvin is high. The maximum concentration varies in the range from 0.5 to 5 mg / l, is reached within 4-5 hours after ingestion of the drug.
The connection with plasma proteins is 80%. Griseofulvin selectively accumulates in the stratum corneum and its appendages, as well as in skeletal muscles, adipose tissue and liver. A small amount of the substance is distributed in tissues and body fluids. The drug crosses the placenta.
Griseofulvin is metabolized in the liver, resulting in the formation of inactive metabolites (6-methylgriseofulvin and a glucuronide derivative). It is excreted by the kidneys (unchanged - about 1%) and through the intestines (unchanged - about 36%). The half-life is 24 hours.
Indications for use
According to the instructions, Griseofulvin is used in the treatment of infectious diseases:
- Epidermophytosis of hands and feet, caused by Trichophyton interdigitale, Trichophyton rubrum;
- Dermatophytosis of smooth skin, scalp and nails caused by fungi sensitive to the agent, including trichophytosis, microsporia and favus.
Contraindications
- Malignant neoplasms;
- Impaired liver and kidney function;
- Pathology of cerebral circulation, including a history;
- Changes in the morphological composition of the blood;
- Uterine bleeding;
- Porphyria;
- Systemic lupus erythematosus;
- Children under 3 years old;
- The period of pregnancy and breastfeeding;
- Hypersensitivity to griseofulvin.
Instructions for the use of Griseofulvin: method and dosage
Griseofulvin tablets are taken orally, with meals, simultaneously with 1 teaspoon of vegetable oil.
Dosage is prescribed depending on the clinical indications and the patient's age:
- Microsporia: for adults - up to 8 pcs. (1000 mg) per day, for children - at the rate of 21-22 mg per 1 kg of body weight per day. It is recommended to take the tablets before the first negative mycological test every day. Further, the treatment takes place in the same dose according to the scheme: 2 weeks the drug is taken every other day and 2 weeks - with a frequency of 2 times a week;
- Trichophytosis, onychomycosis, favus of the scalp: adult patients weighing up to 50 kg - 5 pcs. (625 mg) per day, with a weight of more than 50 kg - for every 10 kg of weight, add 1 tablet (125 mg). The maximum daily dose is 8 pcs. (1000 mg). For children: in the treatment of trichophytosis and favus - the appointment is carried out at the rate of 18 mg per 1 kg of body weight per day, with onychomycosis - at the rate of 16 mg per 1 kg of the child's weight. Treatment of trichophytosis and favus is carried out similarly to microsporia therapy. With onychomycosis, tablets are taken according to the following scheme: the first month - every day, the second month - every other day, then, until the affected nail is completely replaced with a healthy one - 2 times a week. The general course of treatment should last at least 8 months.
Side effects
The use of Griseofulvin can cause the following side effects:
- From the hematopoietic system: leukopenia, rarely - eosinophilia, leukocytosis;
- From the digestive system: dyspepsia;
- From the nervous system: dizziness, headache, disorientation;
- Allergic reactions: skin rash, urticaria.
Overdose
There are no data on cases of overdose.
special instructions
Throughout the entire period of treatment with Griseofulvin, it is necessary to carry out regular (once every 10-15 days) monitoring of the morphological composition of the blood.
Taking pills should be combined with the use of external antifungal agents.
With dermatophytosis of the scalp, it is necessary to wash your hair with soap and warm water 2 times a week and shave your hair once a week.
With onychomycosis, the dead tissue of the affected nails should be systematically removed using keratolytic agents.
With the development of allergic reactions, it is necessary to prescribe antiallergic therapy, in case of an increase in allergic processes, it is necessary to cancel the drug for 3-4 days. After removing the manifestations of allergy, the drug should be resumed with 1/2 tablet per day, and gradually increasing (within 3-4 days), brought to the therapeutic dose.
When treating children, the simultaneous use of multivitamins is recommended.
Influence on the ability to drive vehicles and complex mechanisms
During the period of using the Griseofulvin tablets, patients need to refrain from all types of activities, the implementation of which requires the speed of psychomotor reactions and increased attention.
Application during pregnancy and lactation
The use of the drug is contraindicated during pregnancy and lactation.
Pediatric use
In pediatrics, the drug is used to treat children over 3 years old in accordance with the dosage regimen recommended by the doctor.
With impaired renal function
Griseofulvin is contraindicated in patients with concomitant renal impairment.
For violations of liver function
The drug is contraindicated in patients with concomitant liver dysfunction.
Drug interactions
Barbiturates and primidone reduce the antifungal effect of Griseofulvin.
Griseofulvin enhances the effect of ethanol. Due to the induction of microsomal liver enzymes, the drug reduces the activity of indirect anticoagulants and estrogen-containing oral contraceptives.
Analogs
Griseofulvin analogs are: Terbinafine, Binafin, Lamikan.
Terms and conditions of storage
Store in a dry place out of reach of children.
Terms of dispensing from pharmacies
Dispensed by prescription.
Reviews about Griseofulvin
Few reviews of Griseofulvin testify to its effective antifungal action. However, patients often complain about the development of side effects. In this connection, this drug is not very popular today, and doctors prefer less toxic drugs.
Price for Griseofulvin in pharmacies
The price of Griseofulvin is approximately 227–272 rubles. per pack of 20 tablets.
Griseofulvin: prices in online pharmacies
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Drug name Price Pharmacy |
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Griseofulvin 125 mg tablets 20 pcs. 192 RUB Buy |
Maria Kulkes Medical journalist About the author
Education: First Moscow State Medical University named after I. M. Sechenov, specialty "General Medicine".
Information about the drug is generalized, provided for informational purposes only and does not replace the official instructions. Self-medication is hazardous to health!
